Results 21 to 30 of about 4,008 (211)

H3K18 lactylation marks tissue-specific active enhancers [PDF]

, 2022
Background: Histone lactylation has been recently described as a novel histone post-translational modification linking cellular metabolism to epigenetic regulation.
Castellano-Castillo, Daniel, De Bock, Katrien, de Sousa, Joao Agostinho, Desgeorges, Thibaut, Engl, Magdalena, Galle, Eva, Ghosh, Adhideb, Hinte, Laura C, Melrose, Kate, Ruiz, Jonatan R, Ruiz-Ojeda, Francisco Javier, von Meyenn, Ferdinand, Wong, Chee-Wai   +12 more
core   +4 more sources

Histone lactylation: epigenetic mark of glycolytic switch

Trends in Genetics, 2022
Histone lactylation and acetylation compete for epigenetic modification of lysines and mark the levels of lactates and acetyl-CoA. Whether pyruvate is committed to lactate or acetyl-CoA generation as the outlet of glycolysis determines cell fate towards malignancy or not. Taking control over the glycolytic switch as marked by lactylation suggests novel
Dai, Xiaofeng, Lv, Xinyu, Thompson, Erik W, Ostrikov, Kostya Ken   +3 more
openaire   +3 more sources

Resistance training in humans and mechanical overload in rodents do not elevate muscle protein lactylation [PDF]

, 2023
Although several reports have hypothesized that exercise may increase skeletal muscle protein lactylation, empirical evidence in humans is lacking.
Anglin, Derick A., Fei, Shengyi, Godwin, Joshua S., Kontos, Nicholas J., Mattingly, Madison L., McIntosh, Mason C., Michel, J. Max, Mobley, C. Brooks, Phillips, Stuart M., Plotkin, Daniel L., Roberts, Michael D., Ruple, Auburn University A., Sexton, Casey L., Smith, Morgan A., Vann, Christopher G., Vechetti, Ivan Jose, Jr   +15 more
core   +5 more sources

Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

Genome Biology, 2021
Background Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization.
Jie Yu, Peiwei Chai, Minyue Xie, Shengfang Ge, Jing Ruan, Xianqun Fan, Renbing Jia   +6 more
doaj   +1 more source

Histone lactylation mediated by Fam172a in POMC neurons regulates energy balance

Nature Communications
Glycolysis-derived lactate was identified as substrate for histone lactylation, which has been regarded as a significant role in transcriptional regulation in many tissues.
Zhuo Chen, Baocheng Wan, Hong Zhang, Lina Zhang, Rong Zhang, Lianxi Li, Yi Zhang, Cheng Hu   +7 more
doaj   +3 more sources

Correction: Non-histone lactylation: unveiling its functional significance. [PDF]

Front Cell Dev Biol
Shi P, Ma Y, Zhang S.
europepmc   +3 more sources

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]

, 2020
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana, Guma, Monica, Murillo-Saich, Jessica D   +2 more
core   +2 more sources

Role of D(-)-Lactic Acid in Prevention of Chlamydia trachomatis Infection in an In Vitro Model of HeLa Cells [PDF]

, 2023
A vaginal microbiota dominated by certain Lactobacillus species may have a protective effect against Chlamydia trachomatis infection. One of the key antimicrobial compounds produced is lactic acid, which is believed to play a central role in host defense.
Calonghi, Natalia, Djusse, Marielle Ezekielle, Fato, Romana, Foschi, Claudio, Marangoni, Antonella, Marziali, Giacomo, Morselli, Sara, Naldi, Marina, Rizzardi, Nicola, Zalambani, Chiara   +9 more
core   +1 more source

Lactate Promotes Macrophage HMGB1 Lactylation, Acetylation, and Exosomal Release in Polymicrobial Sepsis [PDF]

, 2021
High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with the severity and mortality of sepsis. However, it is unclear whether lactate could promote HMGB1 release during sepsis.
Fan, Min, Gill, P. S., Ha, Tuanzhu, Li, Chuanfu, Liu, Li, Tu, Fei, Wang, Xiaohui, Wang, Yana, Williams, David L., Xu, Jingjing, Yang, Kun   +10 more
core   +2 more sources

Metabolic regulation of gene expression by histone lactylation [PDF]

Nature, 2019
The Warburg effect, which originally described increased production of lactate in cancer, is associated with diverse cellular processes such as angiogenesis, hypoxia, polarization of macrophages and activation of T cells. This phenomenon is intimately linked to several diseases including neoplasia, sepsis and autoimmune diseases1,2.
Zhang, Di, Tang, Zhanyun, Huang, He, Zhou, Guolin, Cui, Chang, Weng, Yejing, Liu, Wenchao, Kim, Sunjoo, Lee, Sangkyu, Perez-Neut, Mathew, Czyz, Daniel, Hu, Rong, Ye, Zhen, He, Maomao, Zheng, Y. George, Shuman, Howard, Ding, Jun, Dai, Lunzhi, Ren, Bing, Roeder, Robert G., Becker, Lev, Zhao, Yingming   +21 more
openaire   +2 more sources