Epigenetics & Chromatin, 2021 Background Dynamic changes of histone posttranslational modifications are important contexts of epigenetic reprograming after fertilization in pre-implantation embryos.
Wanting Yang +6 more
doaj +1 more source
The Metabolic-Epigenetic Nexus in Type 2 Diabetes Mellitus [PDF]
, 2021 The prevalence of type 2 diabetes mellitus (T2DM) continues to rise globally. Yet the aetiology and pathophysiology of this noncommunicable, polygenic disease, is poorly understood.
Davison, Gareth +2 more
core +2 more sources
Histone lactylation links metabolism and gene regulation [PDF]
Nature, 2019 Cells regulate gene expression in part through the chemical labelling of histone proteins. Discovery of a label derived from lactate molecules reveals a way in which cells link gene expression to nutrient metabolism. Lactylation is a newly discovered epigenetic modification.
Luke T. Izzo, Kathryn E. Wellen
openaire +1 more source
Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells. [PDF]
, 2019 Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modifies the expression of oncogenes, or genes encoding ...
Brooks, George A +4 more
core +1 more source
Impact of Physical Activity and Exercise on the Epigenome in Skeletal Muscle and Effects on Systemic Metabolism [PDF]
, 2022 Julio Plaza-Diaz and Concepcion M. Aguilera are part of the "UGR Plan Propio de Investigacion 2016" and the "Excellence actions: Unit of Excellence on Exercise and Health (UCEES), University of Granada".
Aguilera, Concepción M. +5 more
core +1 more source
Histone lactylation promotes rheumatoid arthritis progression by increasing NFATc2 expression and the production of anti-lactylated histone autoantibodies. [PDF]
Nat CommunWu G +12 more
europepmc +2 more sources
Lactate metabolic reprogramming and histone lactylation modification in sepsis. [PDF]
Int J Biol SciZhang J +8 more
europepmc +3 more sources
Trained immunity in diabetes and hyperlipidemia: Emerging opportunities to target cardiovascular complications and design new therapies [PDF]
, 2023 Some metabolic diseases, such as diabetes and hyperlipidemia, are associated with a state of inflammation, which adversely affects cardiovascular health.
Akbar, Naveed +3 more
core +2 more sources
The expanding constellation of histone post-translational modifications in the epigenetic landscape [PDF]
, 2021 The emergence of a nucleosome-based chromatin structure accompanied the evolutionary transition from prokaryotes to eukaryotes. In this scenario, histones became the heart of the complex and precisely timed coordination between chromatin architecture and
Cavalieri V.
core +1 more source
Integration of transcriptional and metabolic control in macrophage activation [PDF]
, 2021 Macrophages react to microbial and endogenous danger signals by activating a broad panel of effector and homeostatic responses. Such responses entail rapid and stimulus-specific changes in gene expression programs accompanied by extensive rewiring of ...
Ghisletti S +3 more
core +1 more source