Results 41 to 50 of about 4,008 (211)

Lactate Suppresses Immunometabolic and Inflammatory Responses in Monocytes [PDF]

, 2022
Many diseases are preventable through regular exercise. However, high-intensity exercise can transiently suppress immune function. Lactate can decrease inflammatory responses through epigenetic modifications such as histone lactylation, inhibiting ...
Davis, Kierstin Lynn
core   +1 more source

Class I histone deacetylases catalyze lysine lactylation

Journal of Biological Chemistry
AbstractMetabolism and post-translational modifications (PTMs) are intrinsically linked and the number of identified metabolites that can covalently modify proteins continues to increase. This metabolism/PTM crosstalk is especially true for lactate, the product of anaerobic metabolism following glycolysis.
Takeshi Tsusaka, Mohd. Altaf Najar, Isha Sharma, Mariola M. Marcinkiewicz, Claudia Veronica Da Silva Crispim, Nathaniel W. Snyder, George M. Burslem, Emily L. Goldberg   +7 more
openaire   +3 more sources

Re-evaluating the mechanism of histone lactylation

, 2020
Recent work by Zhang et al. published in Nature identified a unique non-metabolic role of the glycolysis end-product lactate, in post-translational lactylation of histones. The original study as well as follow-up editorials allude that lactate after being activated as lactyl-CoA mediates histone lactylation.
Sunada Khadka, Yasaman Barekatain, Florian Muller   +2 more
openaire   +2 more sources

UBE2T‐Driven p53 Degradation Rewires Glycolysis to Orchestrate Lactylation‐Mediated CAFs Activation and ECM Deposition in Pancreatic Cancer

Advanced Science, EarlyView.
This study integrates multi‐omics to reveal the critical role of UBE2T in driving malignancy and stromal co‐evolution in PDAC. UBE2T potentiates glycolysis by regulating p53 degradation via a positive feedback loop, thereby promoting histone H3 lysine 18 lactylation in CAFs and stromal deposition. The UBE2T inhibitor PGG represents a potential strategy
Yong Ma, Wenbo Liu, Mingdou Li, Tao Wang, Bin Zhao, Keshen Wang, Qichen He, Haonan Sun, Huiguo Qing, Xiaoying Guan, Wengui Shi, Long Qin, Yuman Dong, Huinian Zhou, Zeyuan Yu, Xiangyan Jiang, Zuoyi Jiao   +16 more
wiley   +1 more source

Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects [PDF]

, 2021
Lactate is an end product of glycolysis. As a critical energy source for mitochondrial respiration, lactate also acts as a precursor of gluconeogenesis and a signaling molecule. We briefly summarize emerging concepts regarding lactate metabolism, such as
An-Na Chen, Jian-Tao Fu, Jin Yang, Jun-Ping Shi, Xiu-Mei Geng, Yan Luo, Yu-Han Yang   +6 more
core   +1 more source

Histone H3K18 and Ezrin Lactylation Promote Renal Dysfunction in Sepsis‐Associated Acute Kidney Injury

Advanced Science
Histone lactylation is a metabolic stress‐related histone modification. However, the role of histone lactylation in the development of sepsis‐associated acute kidney injury (SA‐AKI) remains unclear.
Jiao Qiao, Yuan Tan, Hongchao Liu, Boxin Yang, Qian Zhang, Qi Liu, Wenyuan Sun, Zhongxin Li, Qingchen Wang, Weimin Feng, Shuo Yang, Liyan Cui   +11 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Lactate:A key regulator of the immune response [PDF]

Lactate, the end product of both anaerobic and aerobic glycolysis in proliferating and growing cells-with the latter process known as the Warburg effect-is historically considered a mere waste product of cell and tissue metabolism. However, research over
Certo, Michelangelo, Gope, Atrayee, Kucuk, Salih, Llibre, Alba, Mauro, Claudio   +4 more
core   +1 more source

Histone lactylation regulates cancer progression by reshaping the tumor microenvironment

Frontiers in Immunology, 2023
As a major product of glycolysis and a vital signaling molecule, many studies have reported the key role of lactate in tumor progression and cell fate determination. Lactylation is a newly discovered post-translational modification induced by lactate. On the one hand, lactylation introduced a new era of lactate metabolism in the tumor microenvironment (
Junxing Qu, Peizhi Li, Zhiheng Sun
openaire   +3 more sources

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source