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The role of histone modifications: from neurodevelopment to neurodiseases
Signal Transduction and Targeted Therapy, 2022 Epigenetic regulatory mechanisms, including DNA methylation, histone modification, chromatin remodeling, and microRNA expression, play critical roles in cell differentiation and organ development through spatial and temporal gene regulation. Neurogenesis
Jisu Park +3 more
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Histone modifications and their role in epigenetics of atopy and allergic diseases
Allergy, Asthma & Clinical Immunology, 2018 This review covers basic aspects of histone modification and the role of posttranslational histone modifications in the development of allergic diseases, including the immune mechanisms underlying this development.
Bilal Alaskhar Alhamwe +11 more
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Histone modifications during the life cycle of the brown alga Ectocarpus
Genome Biology, 2021 Background Brown algae evolved complex multicellularity independently of the animal and land plant lineages and are the third most developmentally complex phylogenetic group on the planet.
Simon Bourdareau +7 more
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Histone Modifications as an Intersection Between Diet and Longevity
Frontiers in Genetics, 2019 Histone modifications are key epigenetic regulators that control chromatin structure and gene transcription, thereby impacting on various important cellular phenotypes.
Diego Molina-Serrano +4 more
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Crossing epigenetic frontiers: the intersection of novel histone modifications and diseases. [PDF]
Signal Transduct Target TherHistone post-translational modifications (HPTMs), as one of the core mechanisms of epigenetic regulation, are garnering increasing attention due to their close association with the onset and progression of diseases and their potential as targeted ...
Yao W, Hu X, Wang X.
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Epigenetic regulation of histone modifications in glioblastoma: recent advances and therapeutic insights [PDF]
Biomarker ResearchGlioblastoma (GBM) is the most common primary malignant brain tumor, characterized by its aggressive behavior, limited treatment options, and poor prognosis. Despite advances in surgery, radiotherapy, and chemotherapy, the median survival of GBM patients
Li Zhang +6 more
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Role of Histone Modifications in Kidney Fibrosis [PDF]
MedicinaChronic kidney disease (CKD) is characterized by persistent kidney dysfunction, ultimately resulting in end-stage renal disease (ESRD). Renal fibrosis is a crucial pathological feature of CKD and ESRD.
Shengyu Pan +5 more
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Histone modifications in head and neck squamous cell carcinoma [PDF]
Frontiers in OncologyHead and neck cancer is the main cause of cancer death worldwide, with squamous cell carcinoma (HNSCC) being the second most frequent subtype. HNSCC poses significant health threats due to its high incidence and poor prognosis, underscoring the urgent ...
Wei Mao +5 more
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Histone modifications in neurodifferentiation of embryonic stem cells
Heliyon, 2022 Post-translational modifications of histone proteins regulate a long cascade of downstream cellular activities, including transcription and replication.
Min Huang +3 more
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Histone Modifications in Alzheimer’s Disease
Genes, 2023 Since Late-onset Alzheimer’s disease (LOAD) derives from a combination of genetic variants and environmental factors, epigenetic modifications have been predicted to play a role in the etiopathology of LOAD.
D. A. Santana +2 more
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