Results 11 to 20 of about 1,862,085 (289)
Single-cell CUT&Tag profiles histone modifications and transcription factors in complex tissues
Nature Biotechnology, 2021 In contrast to single-cell approaches for measuring gene expression and DNA accessibility, single-cell methods for analyzing histone modifications are limited by low sensitivity and throughput.
Marek Bartošovič +2 more
semanticscholar +1 more source
Histone Modifications and Non-Coding RNAs: Mutual Epigenetic Regulation and Role in Pathogenesis
International Journal of Molecular Sciences, 2022 In the last few years, more and more scientists have suggested and confirmed that epigenetic regulators are tightly connected and form a comprehensive network of regulatory pathways and feedback loops.
I. Bure, M. Nemtsova, E. Kuznetsova
semanticscholar +1 more source
Histone variants shape chromatin states in Arabidopsis
eLife, 2023 How different intrinsic sequence variations and regulatory modifications of histones combine in nucleosomes remain unclear. To test the importance of histone variants in the organization of chromatin we investigated how histone variants and histone ...
Bhagyshree Jamge +8 more
doaj +1 more source
Joint profiling of histone modifications and transcriptome in single cells from mouse brain
Nature Methods, 2021 Genome-wide profiling of histone modifications can reveal not only the location and activity state of regulatory elements, but also the regulatory mechanisms involved in cell-type-specific gene expression during development and disease pathology ...
Chenxu Zhu +5 more
semanticscholar +1 more source
Journal of Integrative Plant Biology, 2022 DNA methylation and histone modification are evolutionarily conserved epigenetic modifications that are crucial for the expression regulation of abiotic stress-responsive genes in plants.
Yutong Liu +3 more
semanticscholar +1 more source
mBio, 2020 Histone posttranslational modifications (PTMs) modulate several eukaryotic cellular processes, including transcription, replication, and repair. Vast arrays of modifications have been identified in conventional eukaryotes over the last 20 to 25 years ...
Swati Saha
doaj +1 more source
JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications
Science, 2021 Cryo-EM uncovers polycomb interactions Polycomb family enzymes include the chromatin modifiers PRC1 and PRC2, which are involved in gene repression. Although the catalytic functions of these complexes are well known, their functional relationship is not.
V. Kasinath +8 more
semanticscholar +1 more source
The Histone Modifications of Neuronal Plasticity
Journal of Neural Transplantation and Plasticity, 2021 Nucleosomes composed of histone octamer and DNA are the basic structural unit in the eukaryote chromosome. Under the stimulation of various factors, histones will undergo posttranslational modifications such as methylation, phosphorylation, acetylation ...
Huixia Geng +3 more
semanticscholar +1 more source
Epigenetic mechanisms of Immune remodeling in sepsis: targeting histone modification
Cell Death and Disease, 2023 Sepsis is a life-threatening disorder disease defined as infection-induced dysregulated immune responses and multiple organ dysfunction. The imbalance between hyperinflammation and immunosuppression is a crucial feature of sepsis immunity.
Dan Wu +3 more
doaj +1 more source
Mechanism and Therapeutic Opportunities of Histone Modifications in Chronic Liver Disease
Frontiers in Pharmacology, 2021 Chronic liver disease (CLD) represents a global health problem, accounting for the heavy burden of disability and increased health care utilization. Epigenome alterations play an important role in the occurrence and progression of CLD.
Qiuyu Cai +8 more
doaj +1 more source