Histone modifications during the life cycle of the brown alga Ectocarpus [PDF]
Genome Biology, 2021 Background Brown algae evolved complex multicellularity independently of the animal and land plant lineages and are the third most developmentally complex phylogenetic group on the planet.
Simon Bourdareau +7 more
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Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. [PDF]
PLoS ONE, 2011 Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs.
Tobias D Schneider +6 more
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Histone modifications: Unveiling the epigenetic enigma of degenerative skeletal diseases [PDF]
Journal of Orthopaedic TranslationDegenerative skeletal diseases, including osteoporosis, osteoarthritis, and intervertebral disc degeneration, are prevalent age-related conditions characterized by progressive tissue degeneration and functional decline. Histone modifications are covalent
Yao Zhang +9 more
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Histone Modifications and Cancer [PDF]
Cold Spring Harbor Perspectives in Biology, 2016 Histone posttranslational modifications represent a versatile set of epigenetic marks involved not only in dynamic cellular processes, such as transcription and DNA repair, but also in the stable maintenance of repressive chromatin. In this article, we review many of the key and newly identified histone modifications known to be deregulated in cancer ...
James E, Audia, Robert M, Campbell
openaire +3 more sources
The role of histone modifications: from neurodevelopment to neurodiseases
Signal Transduction and Targeted Therapy, 2022 Epigenetic regulatory mechanisms, including DNA methylation, histone modification, chromatin remodeling, and microRNA expression, play critical roles in cell differentiation and organ development through spatial and temporal gene regulation. Neurogenesis
Jisu Park +3 more
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Histone Modifications as an Intersection Between Diet and Longevity
Frontiers in Genetics, 2019 Histone modifications are key epigenetic regulators that control chromatin structure and gene transcription, thereby impacting on various important cellular phenotypes.
Diego Molina-Serrano +4 more
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Histone modifications and their role in epigenetics of atopy and allergic diseases
Allergy, Asthma & Clinical Immunology, 2018 This review covers basic aspects of histone modification and the role of posttranslational histone modifications in the development of allergic diseases, including the immune mechanisms underlying this development.
Bilal Alaskhar Alhamwe +11 more
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Epigenetic regulation of histone modifications in glioblastoma: recent advances and therapeutic insights [PDF]
Biomarker ResearchGlioblastoma (GBM) is the most common primary malignant brain tumor, characterized by its aggressive behavior, limited treatment options, and poor prognosis. Despite advances in surgery, radiotherapy, and chemotherapy, the median survival of GBM patients
Li Zhang +6 more
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Therapeutic Targeting of Histone Modifications in Adult and Pediatric High-Grade Glioma [PDF]
Frontiers in Oncology, 2017 Recent exciting work partly through The Cancer Genome Atlas has implicated epigenetic mechanisms including histone modifications in the development of both pediatric and adult high-grade glioma (HGG).
Kurian, Kathreena M +4 more
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Editorial: Histone modifications in cancer [PDF]
Frontiers in PharmacologyJiaqian Luo, Sizhi P. Gao
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