Results 21 to 30 of about 1,862,085 (289)
Identifying the Combinatorial Effects of Histone Modifications by Association Rule Mining in Yeast
Evolutionary Bioinformatics, 2010 Eukaryotic genomes are packaged into chromatin by histone proteins whose chemical modification can profoundly influence gene expression. The histone modifications often act in combinations, which exert different effects on gene expression.
Caisheng He +6 more
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Histone modifications centric-regulation in osteogenic differentiation
Cell Death Discovery, 2021 Histone modification critically contributes to the epigenetic control of gene expression by changing the configuration of chromatin and modifying the access of transcription factors to gene promoters.
Kun Li, Jinxiang Han, Ziqiang Wang
semanticscholar +1 more source
Modeling exon expression using histone modifications. [PDF]
PLoS ONE, 2013 Histones undergo numerous covalent modifications that play important roles in regulating gene expression. Previous investigations have focused on the effects of histone modifications on gene promoters, whereas efforts to unravel their effects on ...
Shijia Zhu +3 more
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The roles of histone modifications in tumorigenesis and associated inhibitors in cancer therapy
Journal of the National Cancer Center, 2022 Histone modifications are key factors in chromatin packaging, and are responsible for gene regulation during cell fate determination and development. Abnormal alterations in histone modifications potentially affect the stability of the genome and disrupt
Yunkai Yang, Min Zhang, Yan Wang
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Co-regulation of histone-modifying enzymes in cancer. [PDF]
PLoS ONE, 2011 Cancer is characterized by aberrant patterns of expression of multiple genes. These major shifts in gene expression are believed to be due to not only genetic but also epigenetic changes.
Abul B M M K Islam +4 more
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The function of histone methylation and acetylation regulators in GBM pathophysiology
Frontiers in Oncology, 2023 Glioblastoma (GBM) is the most common and lethal primary brain malignancy and is characterized by a high degree of intra and intertumor cellular heterogeneity, a starkly immunosuppressive tumor microenvironment, and nearly universal recurrence.
Colin McCornack +7 more
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The inheritance of histone modifications depends upon the location in the chromosome in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2011 Histone modifications are important epigenetic features of chromatin that must be replicated faithfully. However, the molecular mechanisms required to duplicate and maintain histone modification patterns in chromatin remain to be determined.
Hiroshi Masumoto +4 more
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GoPeaks: histone modification peak calling for CUT&Tag
Genome Biology, 2022 Genome-wide mapping of histone modifications is critical to understanding transcriptional regulation. CUT&Tag is a new method for profiling histone modifications, offering improved sensitivity and decreased cost compared with ChIP-seq.
William M. Yashar +8 more
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Combinatorial Pattern of Histone Modifications in Exon Skipping Event
Frontiers in Genetics, 2019 Histone modifications are associated with alternative splicing. It has been suggested that histone modifications act in combinational patterns in gene expression regulation.
Wei Chen +4 more
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Epigenetics, 2023 Histones are subjected to extensive covalent modifications that affect inter-nucleosomal interactions as well as alter chromatin structure and DNA accessibility.
Yang Yu +4 more
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