Results 61 to 70 of about 5,681,501 (240)

MOESM1 of Modulation of nucleosomal DNA accessibility via charge-altering post-translational modifications in histone core

, 2018
Additional file 1. Supplementary information to: modulation of nucleosomal DNA accessibility via charge altering post-translational modifications in histone ...
Andrew Fenley (4972963), Alexey Onufriev (10126), Alexey V. Onufriev, Fenley, Andrew T., Yared Kidane (3805936), Yared H. Kidane, Anandakrishnan, Ramu, Ramu Anandakrishnan (294535), Onufriev, Alexey V., Kidane, Yared H., Andrew T. Fenley, Ramu Anandakrishnan   +11 more
core   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Impact of embryonic heat acclimation on histone post-translational modifications in chicken

, 2016
Impact of embryonic heat acclimation on histone post-translational modifications in chicken.
Bigot, Yves, Couroussé, Nathalie, David, Sarah-Anne, Jacques, Aurore, Piegu, Benoit, Hennequet-Antier, Christelle, Bordeau, Thierry, Collin, Anne, Coustham, Vincent, Crochet, Sabine, Beauclair, Linda   +10 more
core   +2 more sources

Unraveling the complexity of the histone code: implications for gene regulation and disease

Genome Biology
Histone post-translational modifications epigenetically regulate gene expression by modulating nucleosome structure and DNA accessibility. This review outlines how unique patterns of modifications on canonical and variant histones generate a ...
Kiera L. Malone, Ajit K. Singh, James M. Lignos, Elizabeth D. Cook, Margaret Phillips, Brian W. Boyle, Isabelle A. Kressy, Mirabella Vulikh, Annika K. Lathrop, Kyle T. McKay, Hassan Zafar, Janet L. Stein, Gary S. Stein, Karen C. Glass   +13 more
doaj   +1 more source

Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis. [PDF]

, 2010
Histone modifications are critical in regulating gene expression, cell cycle, cell proliferation, and development. Relatively few studies have investigated whether Helicobacter pylori, the major cause of human gastric diseases, affects histone ...
Haas, Rainer, Rainer Haas, Grant, Patrick, Kaparakis-Liaskos, Maria, Hass, Rainer, Sheila E Crowe, Patrick A. Grant, Crowe, Sheila E., Crowe Sheila E., Liechti, George, Ferrero, Richard L., Richard L. Ferrero, D. Scott Merrell, Kaparakis-Liaskos Maria, Merrell, D. Scott, Wolfgang Fischer, Fischer, Wolfgang, Liechti George, Ferrero Richard L., Ding, Song-Ze, Goldberg Joanna B., Song-Ze Ding, Ding Song-Ze, George Liechti, Patrick A Grant, Crowe, Sheila, Goldberg, Joanna, Fischer Wolfgang, Joanna B Goldberg, D Scott Merrell, Hatakeyama, Masanori, Ferrero, Richard, Merrell D. Scott, Haas Rainer, Joanna B. Goldberg, Goldberg, Joanna B., Richard L Ferrero, Sheila E. Crowe, Masanori Hatakeyama, Grant Patrick A., Hatakeyama Masanori, Grant, Patrick A., Liaskos, Maria, Maria Kaparakis-Liaskos   +43 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Histone post-translational modifications to target memory-related diseases.

, 2013
Epigenetic mechanisms, i.e. the control gene of expression without changing DNA sequence, include DNA methylation, histone post-translational modifications (PTMs) and microRNAs (miRNAs).
MONTI, BARBARA
core   +1 more source