Results 71 to 80 of about 5,681,501 (240)

Effects of Post-Translational Histone Modifications on Transcription Rate [PDF]

, 2023
The structural organization of DNA in eukaryotic cells is greatly implicated in the regulation of gene expression and thus cellular properties and behavior.
Bohn, Aaron, Ricks, Sarah, Bates, David, Ph.D, Johnson, Steven M., Ph.D, Hodson, Sarah   +4 more
core  

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Ubiquitin Regulation: The Histone Modifying Enzyme′s Story

Cells, 2018
Histone post-translational modifications influence many fundamental cellular events by regulating chromatin structure and gene transcriptional activity.
Jianlin Wang, Zhaoping Qiu, Yadi Wu
doaj   +1 more source

H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. [PDF]

, 2013
Histone lysine (K) methylation has been shown to play a fundamental role in modulating chromatin architecture and regulation of gene expression. Here we report on the identification of histone H3K56, located at the pivotal, nucleosome DNA entry/exit ...
Pünzeler, Sebastian, Sebastian Pünzeler (381339), Gunnar Schotta (116394), Jack, Antonia P. M., Michael Wells (381341), Bussemer, Silva, Martha Snyder (381340), Hake, Sandra B., Matthias Hahn, Irina Solovei, Solovei, Irina, Hahn, Matthias, Wells, Michael, Gunnar Schotta, Sebastian Pünzeler, Martha Snyder, Sandra B. Hake (165089), Matthias Hahn (209009), Antonia P. M. Jack (381337), Irina Solovei (85), Sandra B Hake, Silva Bussemer, Michael Wells, Antonia P M Jack, Silva Bussemer (381338), Gyorgyi Csankovszki (5654086), Snyder, Martha, Schotta, Gunnar, Csankovszki, Gyorgyi, Gyorgyi Csankovszki   +29 more
core   +2 more sources

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Targeting epigenetic and post-translational modifications regulating pyroptosis for the treatment of inflammatory diseases

Pharmacological Research
Inflammatory diseases, including infectious diseases, diabetes-related diseases, arthritis-related diseases, neurological diseases, digestive diseases, and tumor, continue to threaten human health and impose a significant financial burden despite ...
Ri-Wen, Yu-Hang Yang, Tie-Ning Zhang, Chun-Feng Liu, Ni Yang   +4 more
doaj   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Enhanced top-down characterization of histone post-translational modifications [PDF]

, 2012
Post-translational modifications (PTMs) of core histones work synergistically to fine tune chromatin structure and function, generating a so-called histone code that can be interpreted by a variety of chromatin interacting proteins.
Errol W Robinson, Robinson,Errol W, Rui Zhao, Richard D Smith, Tian,Zhixin, Toli?,Nikola, Zhixin Tian, Si Wu, Stenoien,David L, Ljiljana Paša-Tolić, Shawna M Hengel, David L Stenoien, Moore,Ronald J, Nikola Tolić, Pa?a-Toli?,Ljiljana, Smith,Richard D, Wu,Si, Hengel,Shawna M, Ronald J Moore, Zhao,Rui   +19 more
core   +1 more source