Results 81 to 90 of about 130,653 (144)

Targeting epigenetic and post-translational modifications regulating pyroptosis for the treatment of inflammatory diseases

Pharmacological Research
Inflammatory diseases, including infectious diseases, diabetes-related diseases, arthritis-related diseases, neurological diseases, digestive diseases, and tumor, continue to threaten human health and impose a significant financial burden despite ...
Ri-Wen, Yu-Hang Yang, Tie-Ning Zhang, Chun-Feng Liu, Ni Yang   +4 more
doaj   +1 more source

Roles of the histone methyltransferase G9a in the development and differentiation of mesenchymal tissues

Journal of Physical Fitness and Sports Medicine, 2015
The expression of cell lineage-specific genes during cell differentiation and development is regulated by lineage-specific transcription factors. Recent studies have revealed that epigenetic mechanisms, including post-translational modifications in ...
Hisashi Ideno, Kazuhisa Nakashima, Akira Nifuji   +2 more
doaj   +1 more source

Nejire/dCBP-mediated control of H3 acetylation and transcriptional regulation by testis-specific Plus3 domain proteins during Drosophila spermatogenesis [PDF]

, 2018
Spermatogenesis describes the development from germ line stem cells to highly specialized sperm. Drosophila melanogaster spermatogenesis is a good model system for chromatin remodelling processes as many of these processes are similar in mammals and in ...
Hundertmark, Tim
core   +1 more source

Nickel binding sites in histone proteins [PDF]

, 2012
Nickel compounds are well known as human carcinogens, though the molecular events that are responsible for this are not well understood. It has been proposed that a crucial element in the mechanism of carcinogenesis is the binding of Ni(II) ions within
Medici, Serenella, Peana, Massimiliano Francesco, Solinas, Costantino, Zoroddu, Maria Antonietta   +3 more
core  

The bromodomain-containing protein Ibd1 links multiple chromatin related protein complexes to highly expressed genes in Tetrahymena thermophila

, 2018
Background: The chromatin remodelers of the SWI/SNF family are critical transcriptional regulators. Recognition of lysine acetylation through a bromodomain (BRD) component is key to SWI/SNF function; in most eukaryotes, this function is attributed to ...
Burtch, Alyson, Fillingham, Jeffrey, Garg, Jyoti, Gingras, Anne-Claude, Lambert, Jean-Philippe, Mudalige, Cristina Thuppu, Nabeel-Shah, Syed, Pearlman, Ronald E., Ponce, Marcelo, Saettone, Alejandro   +9 more
core   +1 more source

TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization [PDF]

, 2015
The ends of eukaryotic chromosomes need to be protected from the activation of a DNA damage response that leads the cell to replicative senescence or apoptosis.
Alicata, Claudia, Cacchione, Stefano, Cicconi, Alessandro, Galati, Alessandra, Gilson, Eric, Giraud Panis, Marie Josèphe, Ingegnere, Tiziano, Micheli, Emanuela, Pusch, Miriam Caroline   +8 more
core   +3 more sources

Roles of Histone Acetylation and Deacetylation in Root Development

Plants
Roots are usually underground plant organs, responsible for anchoring to the soil, absorbing water and nutrients, and interacting with the rhizosphere.
Christos Tersenidis, Stylianos Poulios, George Komis, Emmanuel Panteris, Konstantinos Vlachonasios   +4 more
doaj   +1 more source

Mass-spectrometry analysis of histone post-translational modifications in pathology tissue using the PAT-H-MS approach

Data in Brief, 2016
Aberrant histone post-translational modifications (hPTMs) have been implicated with various pathologies, including cancer, and may represent useful epigenetic biomarkers.
Roberta Noberini, Giancarlo Pruneri, Saverio Minucci, Tiziana Bonaldi   +3 more
doaj   +1 more source

Beyond DNA: Epigenetics and Proteomics in Forensic Science [PDF]

, 2016
The use of genetic evidence in criminal cases is well established and has improved the public opinion and credibility of forensic science. However, several shortcomings associated with current genetic profiling techniques exist. Scientific research aimed
Eilerts, Diane F
core   +1 more source

Balancing noise and plasticity in gene expression [PDF]

, 2011
Coupling the control of expression stochasticity (noise) with the capacity to expression change (plasticity) can constrain gene function and limit adaptation. Which factors contribute then to modulate this coupling?
Djordje Bajic, Juan F. Poyatos
core   +1 more source