Results 1 to 10 of about 33,958 (207)

Inducible HIV-1 Reservoir Reduction Assay (HIVRRA), a Fast and Sensitive Assay to Test Cytotoxicity and Potency of Cure Strategies to Reduce the Replication-Competent HIV-1 Reservoir in Ex Vivo PBMCs. [PDF]

Bio Protoc
The HIV-1 reservoir, consisting of transcriptionally silent integrated HIV-1 proviruses, is a major barrier to a cure, as it persists during effective antiretroviral therapy (ART) and is the source of viral rebound upon treatment interruption.
Jansen J, Geijtenbeek TBH, Kootstra NA.
europepmc   +2 more sources

Atlas of the HIV-1 Reservoir in Peripheral CD4 T Cells of Individuals on Successful Antiretroviral Therapy. [PDF]

mBio, 2021
Knowing the mechanisms that govern the persistence of infected CD4+ subpopulations could help us to design new therapies to cure HIV-1 infection. We evaluated the simultaneous distribution of the HIV-1 reservoir in 13 CD4+ subpopulations from 14 HIV-1 ...
Gálvez C, Grau-Expósito J, Urrea V, Clotet B, Falcó V, Buzón MJ, Martinez-Picado J.   +6 more
europepmc   +2 more sources

Inducible HIV-1 Reservoir Quantification: Clinical Relevance, Applications and Advancements of TILDA. [PDF]

Front Microbiol, 2021
The presence of a stable HIV-1 reservoir persisting over time despite effective antiretroviral suppression therapy precludes a cure for HIV-1. Characterizing and quantifying this residual reservoir is considered an essential prerequisite to develop and ...
Lungu C, Banga R, Gruters RA, Procopio FA.   +3 more
europepmc   +2 more sources

BACH2 promotes seeding and establishment of long-lived HIV-1 reservoir in memory CD4⁺ T cells. [PDF]

Cell Rep Med
Summary: Despite antiretroviral therapy, HIV-1 mainly persists in memory CD4+ T cells in people living with HIV-1. Most long-lived viral reservoir cells are infected by the virus near the time of therapy initiation.
Gao H, Li Y, Tiwari R, Pinzone M, Qin X, Clark KM, Nicholson SK, Yao T, Rome K, Scaglione M, Bailis W, Presti RM, Sereti I, Saligrama N, Wang L, Shan L.   +15 more
europepmc   +2 more sources

Noncanonical-NF-κB activation and DDX3 inhibition reduces the HIV-1 reservoir by elimination of latently infected cells ex-vivo. [PDF]

Microbiol Spectr
Latency reversal and subsequent elimination of the human immunodeficiency virus-1 (HIV-1) reservoir using a combination of compounds with different mechanisms of action are considered a promising tool for HIV-1 cure.
Jansen J, Kroeze S, Man S, Andreini M, Bakker J-W, Zamperini C, Tarditi A, Kootstra NA, Geijtenbeek TBH.   +8 more
europepmc   +2 more sources

Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts. [PDF]

Nat Commun
Eliminating latent HIV-1 is a major goal of AIDS research but host factors determining the size of these reservoirs are poorly understood. Here, we investigate the role of host gene expression on HIV-1 reservoir size during suppressive antiretroviral ...
Ehrenberg PK, Geretz A, Volcic M, Izumi T, Yum LK, Waickman A, Shangguan S, Paquin-Proulx D, Creegan M, Bose M, Machmach K, McGraw A, Narahari A, Currier JR, Sacdalan C, Phanuphak N, Apps R, Corley M, Ndhlovu LC, Slike B, Krebs SJ, Anonworanich J, Tovanabutra S, Robb ML, Eller MA, Laird GM, Cyktor J, Daar ES, Crowell TA, Mellors JW, Vasan S, Michael NL, Kirchhoff F, Thomas R.   +33 more
europepmc   +2 more sources

Spatial technologies to evaluate the HIV-1 reservoir and its microenvironment in the lymph node. [PDF]

mBio
The presence of the HIV-1 reservoir, a group of immune cells that contain intact, integrated, and replication-competent proviruses, is a major challenge to cure HIV-1.
Zaman F, Smith ML, Balagopal A, Durand CM, Redd AD, Tobian AAR.   +5 more
europepmc   +2 more sources

Assessing advances in three decades of clinical antiretroviral therapy on the HIV-1 reservoir. [PDF]

J Clin Invest
BACKGROUND Antiretroviral therapy (ART) has improved the clinical management of HIV-1 infection. However, little is known about how the latest ART recommendations affect the heterogeneity of the HIV-1 reservoir size.METHODS We used a complete statistical
González-Navarro I, Urrea V, Gálvez C, Garcia-Guerrero MDC, Morón-López S, Puertas MC, Grau E, Mothe B, Bailón L, Miranda C, García F, Leal L, Vandekerckhove L, Marconi VC, Sekaly RP, Clotet B, Martinez-Picado J, Salgado M, NIH Reversing Immune Dysfunction for HIV-1 Eradication (RID-HIV) Collaboratory Group.   +18 more
europepmc   +2 more sources

Specific quantification of inducible HIV-1 reservoir by RT-LAMP. [PDF]

Commun Med (Lond)
Background Strategies toward HIV-1 cure aim to clear, inactivate, reduce, or immunologically control the virus from a pool of latently infected cells such that combination antiretroviral therapy (cART) can be safely interrupted.
Hossain T, Lungu C, de Schrijver S, Kuali M, Crespo R, Reddy N, Ngubane A, Kan TW, Reddy K, Rao S, Palstra RJ, Madlala P, Ndung'u T, Mahmoudi T.   +13 more
europepmc   +2 more sources

Identification of CD98 as a Novel Biomarker for HIV-1 Permissiveness and Latent Infection

mBio, 2022
Human immunodeficiency virus type 1 (HIV-1) can integrate viral DNA into host cell chromosomes to establish a long-term stable latent reservoir, which is a major obstacle to cure HIV-1 infection. The characteristics of the HIV-1 latent reservoir have not
Wanying Zhang, Mo Zhou, Cancan Chen, Shiyu Wu, Lilin Wang, Baijin Xia, Jun Liu, Xiancai Ma, Ting Pan, Hui Zhang, Linghua Li, Bingfeng Liu   +11 more
doaj   +1 more source