Results 171 to 180 of about 33,958 (207)
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Current Infectious Disease Reports, 1999
The success of antiretroviral therapy for HIV-1 infection has generated interest in mechanisms by which the virus can persist in the body despite the presence of drugs that effectively inhibit key steps in the virus life cycle. There are several potential cellular and anatomic reservoirs for HIV-1.
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The success of antiretroviral therapy for HIV-1 infection has generated interest in mechanisms by which the virus can persist in the body despite the presence of drugs that effectively inhibit key steps in the virus life cycle. There are several potential cellular and anatomic reservoirs for HIV-1.
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Markers of the HIV-1 reservoir
Current Opinion in HIV and AIDS, 2018The HIV-1 reservoir is composed of infected cells poised to replicate and spread the virus upon treatment interruption. It constitutes the main obstacle toward an HIV-1 cure. Whether marker(s) may allow the detection of cells that form the reservoir is an outstanding question.
Timothée, Bruel, Olivier, Schwartz
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HIV-1 in semen: an isolated virus reservoir
The Lancet, 1997/L, no known infected, andnormal genitourological examination at the time ofspecimen donation. Protease-gene sequences weredetermined for 11 blood and eight semen virus clones frompatient A who had not received antiretroviral therapy, andfrom nine blood and nine semen virus clones from patient Bwho had been on antiretroviral therapy for several years ...
R A, Byrn +4 more
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HIV-1 reservoir dynamics in CD4+ T cells
Current Opinion in HIV and AIDS, 2019To provide a summary of the recent data examining infected CD4+ T cell dynamics during ART and implications for cure strategies.HIV-1 cure is a worldwide unmet medical need. Although combination antiretroviral therapies effectively suppress HIV-1 replication in vivo, viral rebound occurs shortly after therapy cessation.
Katherine M, Bruner, Lillian B, Cohn
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Quantification of the reservoir of HIV-1
Trends in Microbiology, 1997germinal centres can be differentiated by the type of in situ signal seen: infected mononuclear cells give a localized signal over a single cell, and trapped virions give a diffuse signal over germinal centres. The use of radioactive probes allows an estimate of viral copy number to be made (calculated using the specific activity of the probe, the ...
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The prostate as a reservoir for HIV-1
AIDS, 2004As the prostate can harbor bacterial and fungal pathogens, it was investigated as a reservoir for HIV. Nine men chronically infected with HIV participated in a crossover trial in which weekly semen samples were collected with and without previous prostate massage (PM).
Davey M, Smith +5 more
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The Challenge of Viral Reservoirs in HIV-1 Infection
Annual Review of Medicine, 2002▪ Abstract A viral reservoir is a cell type or anatomical site in association with which a replication-competent form of the virus accumulates and persists with more stable kinetic properties than the main pool of actively replicating virus. This article reviews several cell types and anatomical sites proposed as potential reservoirs for HIV-1.
Joel N, Blankson +2 more
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HIV-1 Compartmentalization and Reservoir Formation
2020With over 37 million people living with HIV-1, and over one million new infections occurring each year, HIV-1 continues to be a significant public health burden. Current therapies that eliminate viral replication are not curative and require life-long adherence, placing substantial economic, social, and physical burdens on people living with HIV-1. The
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Current opinion in investigational drugs (London, England : 2000), 2003
HIV-1 infection can now be treated effectively in many patients in the developed world, using combination antiretroviral therapeutics, called highly active antiretroviral therapy (HAART). Nevertheless, these regimens do not cure HIV-1 infection. Residual disease is maintained via proviral latency in resting CD4+ T-lymphocytes and possibly monocytes ...
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HIV-1 infection can now be treated effectively in many patients in the developed world, using combination antiretroviral therapeutics, called highly active antiretroviral therapy (HAART). Nevertheless, these regimens do not cure HIV-1 infection. Residual disease is maintained via proviral latency in resting CD4+ T-lymphocytes and possibly monocytes ...
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Dynamic characteristics of HIV-1 reservoirs.
Current opinion in HIV and AIDS, 2009To examine kinetic issues related to the stability of the latent reservoir and the observation of low levels of viremia (< 50 copies/ml) in patients treated with highly active antiretroviral therapy.Once HIV-1 RNA becomes undetectable it is difficult to deduce the events occurring in HIV-infected individuals. Analyses of viral blips and genetic changes
Hwijin, Kim, Alan S, Perelson
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