Results 21 to 30 of about 33,958 (207)

Emerging PCR-Based Techniques to Study HIV-1 Reservoir Persistence

Viruses, 2020
While current antiretroviral therapies are able to halt HIV-1 progression, they are not curative, as an interruption of treatment usually leads to viral rebound.
Laurens Lambrechts, Basiel Cole, Sofie Rutsaert, Wim Trypsteen, Linos Vandekerckhove   +4 more
doaj   +1 more source

Visualization of HIV-1 reservoir: an imaging perspective. [PDF]

Curr Opin HIV AIDS, 2021
Purpose of review The persistence of HIV-1-infected cells, despite the introduction of the combinatorial antiretroviral therapy, is a major obstacle to HIV-1 eradication. Understanding the nature of HIV reservoir will lead to novel therapeutic approaches for the functional cure or eradication of the virus.
Chapon C, Moysi E, Naninck T, Mayet C, Petrovas C.   +4 more
europepmc   +3 more sources

Targeting the Latent Reservoir for HIV-1 [PDF]

Immunity, 2018
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within weeks of treatment interruption. The major barrier to a cure is a small pool of resting memory CD4+ T cells that harbor latent HIV-1 proviruses.
Srona, Sengupta, Robert F, Siliciano
openaire   +2 more sources

Unintegrated HIV-1 provides an inducible and functional reservoir in untreated and highly active antiretroviral therapy-treated patients

Retrovirology, 2007
Background The presence of HIV-1 preintegration reservoir was assessed in an in vitro experimental model of latent HIV-1 infection, and in patients treated or not with highly active antiretroviral therapy (HAART).
Baillat Vincent, Mettling Clement, Tuaillon Edouard, Al Tabaa Yassine, Petitjean Gaël, Reynes Jacques, Segondy Michel, Vendrell Jean   +7 more
doaj   +1 more source

Measuring the HIV-1 reservoir [PDF]

Nature Reviews Microbiology, 2019
The description of a method to measure the HIV-1 reservoir that quantifies intact and defective proviruses.
openaire   +2 more sources

Chimpanzee Reservoirs of Pandemic and Nonpandemic HIV-1 [PDF]

Science, 2006
Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome (AIDS), is a zoonotic infection of staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir.
Keele, B. F., Van Heuverswyn, F., Li, Y.Y., Bailes, E., Takehisa, J., Santiago, M. L., Bibollet Ruche, F., Chen, Y. L., Wain, L. V., /Liégeois, Florian, Loul, S., Mpoudi Ngolé, E., Bienvenue, Y., /Delaporte, Eric, Brookfield, J. F. Y., Sharp, P. M., Shaw, G. M., /Peeters, Martine, Hahn, B. H.   +18 more
openaire   +5 more sources

B Lymphocytes, but Not Dendritic Cells, Efficiently HIV-1 Trans Infect Naive CD4 ⁺ T Cells: Implications for the Viral Reservoir

mBio, 2021
The latent human immunodeficiency virus type 1 (HIV-1) reservoir in persons on antiretroviral therapy (ART) represents a major barrier to a cure. Although most studies have focused on the HIV-1 reservoir in the memory T cell subset, replication-competent
Abigail Gerberick, Diana C. DeLucia, Paolo Piazza, Mounia Alaoui-El-Azher, Charles R. Rinaldo, Nicolas Sluis-Cremer, Giovanna Rappocciolo   +6 more
doaj   +1 more source

Repurposing BCL-2 and Jak 1/2 inhibitors: Cure and treatment of HIV-1 and other viral infections

Frontiers in Immunology, 2022
B cell lymphoma 2 (BCL-2) family proteins are involved in the mitochondrial apoptotic pathway and are key modulators of cellular lifespan, which is dysregulated during human immunodeficiency virus type 1 (HIV-1) and other viral infections, thereby ...
Monica D. Reece, Colin Song, Sarah C. Hancock, Susan Pereira Ribeiro, Deanna A. Kulpa, Christina Gavegnano, Christina Gavegnano, Christina Gavegnano, Christina Gavegnano, Christina Gavegnano   +9 more
doaj   +1 more source

HIV-1 Genomes Are Enriched in Memory CD4 ⁺ T-Cells with Short Half-Lives

mBio, 2021
The design of future HIV-1 curative therapies requires a more thorough understanding of the distribution of genetically intact HIV-1 within T-cell subsets as well as the cellular mechanisms that maintain this reservoir.
Vincent Morcilla, Charline Bacchus-Souffan, Katie Fisher, Bethany A. Horsburgh, Bonnie Hiener, Xiao Qian Wang, Timothy E. Schlub, Mark Fitch, Rebecca Hoh, Frederick M. Hecht, Jeffrey N. Martin, Steven G. Deeks, Marc K. Hellerstein, Joseph M. McCune, Peter W. Hunt, Sarah Palmer   +15 more
doaj   +1 more source

A Dynamic Interplay of Circulating Extracellular Vesicles and Galectin-1 Reprograms Viral Latency during HIV-1 Infection

mBio, 2022
Combined Antiretroviral therapy (cART) suppresses HIV replication but fails to eradicate the virus, which persists in a small pool of long-lived latently infected cells. Immune activation and residual inflammation during cART are considered to contribute
Julia Rubione, Paula S. Pérez, Alejandro Czernikier, Gabriel A. Duette, Federico Pehuen Pereyra Gerber, Jimena Salido, Martina P. Fabiano, Yanina Ghiglione, Gabriela Turk, Natalia Laufer, Alejandro J. Cagnoni, Juan M. Pérez Sáez, Joaquín P. Merlo, Carla Pascuale, Juan C. Stupirski, Omar Sued, Manuel Varas-Godoy, Sharon R. Lewin, Karina V. Mariño, Gabriel A. Rabinovich, Matías Ostrowski   +20 more
doaj   +1 more source