Results 41 to 50 of about 25,300,433 (384)

Acacetin alleviates neuroinflammation and oxidative stress injury via the Nrf2/HO-1 pathway in a mouse model of spinal cord injury

Translational Neuroscience, 2022
Spinal cord injury (SCI) is a severe central nervous system disease, which may cause serious locomotor deficit. Acacetin is a flavone that possesses antioxidant and anti-inflammatory effects in different human diseases. The main purpose of this study was
Zhang Xin, Xu Lijun, Chen Xiang, Zhou Xianjie, Cao Lanhua   +4 more
doaj   +1 more source

Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling [PDF]

, 2018
Although concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen.
A Arfe, A Bauer, A Kardosh, A Salminen, AJ Shaywitz, B Fisslthaler, BR Gunter, C Liu, C Mo, C Patrono, CC Thornton, CH He, D Carling, DH Solomon, DM Thomson, EH Kobayashi, EL Fosbol, FY Li, H Mylroie, HP Lin, HT Cheng, I Tegeder, IE Schauer, J Lindhardsen, J Steffel, JA Mitchell, JM Cacicedo, JS Wang, K Iwasaki, K Zimmermann, LC Wu, ME Widlansky, MP Seldon, MP Soares, MT Nurmohamed, N Bhala, NJ Goodson, NM Davies, NM Davies, P Kale, PA Watson, R Chenevard, R Gozzelino, RS Bresalier, S Jacob, S Trelle, SE Nissen, SK Paulson, SK Paulson, SL Colombo, SS Hamdulay, SS Hamdulay, SW Ryter, TD Penning, TM MacDonald, VL King, WB White, X Liu, XM Liu, Y Hattori, ZQ Zou   +60 more
core   +4 more sources

HO‐1 expression in primary cultured astroglial cells [PDF]

Journal of Neurochemistry, 2003
Heme oxygenase (HO)‐1 catalyzes the rate‐limiting step in heme degradation. The aim of the study was to determine HO‐1 expression and distribution pattern in glial cells during differentiation and after exposure to glutamate (GLU) (100 μm). In untreated cells at 7 days in vitro (DIV) HO‐1 expression was undetectable whereas increased at 14 and 21 DIV ...
LI VOLTI, Giovanni, IENTILE R, VANELLA A, CANNAV G, RACITI, Giuseppina, CURR M, CAMPISI, Agatina   +6 more
openaire   +3 more sources

Nrf2/HO-1 Axis Regulates the Angiogenesis of Gastric Cancer via Targeting VEGF

Cancer Management and Research, 2021
Yunning Huang,1,* Yuanyuan Yang,2,* Yuanyi Xu,2,* Qian Ma,3,4,* Fengying Guo,2 Yuan Zhao,2 Yuejia Tao,2 Mengqi Li,2 Jiaxin Guo2 1Department of Gastrointestinal Surgery, The Affiliated People’s Hospital of Ningxia Medical University, Yinchuan City ...
Huang Y, Yang Y, Xu Y, Ma Q, Guo F, Zhao Y, Tao Y, Li M, Guo J   +8 more
doaj  

Functional expression of human heme oxygenase-1 (HO-1) driven by HO-1 promoter in vitro and in vivo [PDF]

Journal of Cellular Biochemistry, 2002
AbstractWe developed a retrovirus‐mediated human heme oxygenase‐1 (HO‐1) gene expression system and assessed the impact of heme on the inducibility of the HO‐1 gene in rat lung microvessel (RLMV) endothelial cells and in newborn Sprague‐Dawley (SD) rats.
Shuo, Quan, Liming, Yang, Sylvia, Shenouda, Houli, Jiang, Michael, Balazy, Michal L, Schwartzman, Ichiyo, Shibahara, Kousei, Shinohara, Nader G, Abraham   +8 more
openaire   +2 more sources

CD40LG mutations in Vietnamese patients with X‐linked hyper‐IgM syndrome; catastrophic anti‐phospholipid syndrome as a new complication

Molecular Genetics & Genomic Medicine, 2021
Background X‐linked hyper‐IgM syndrome (XHIGM) is a rare primary immunodeficiency caused by CD40 ligand defects. Methods We identified three patients with XHIGM in Ho Chi Minh City, Vietnam. Whole‐exome sequencing, immunological analyses and western blot
Anh Nguyen Lien Phan, Thuy Thi Thanh Pham, Xinh Thi Phan, Nghia Huynh, Tuan Minh Nguyen, Cuc Tran Thu Cao, Duong Thuy Nguyen, Khanh Thi Xuan Luong, Tam Thi Minh Nguyen, Anh Ngoc Kim Tran, Linh Thi Truc Pham, Vy Vuong Thao Nguyen, Sigrid Swagemakers, Chi‐Bao Bui, Petrus Martinus Van Hagen   +14 more
doaj   +1 more source

Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells

Oxidative Medicine and Cellular Longevity, 2020
Ferroptosis is a form of oxidative cell death and has become a chemotherapeutic target for cancer treatment. Curcumin (CUR), a well-known cancer inhibitor, significantly inhibits the viability of breast cancer cells.
Ruihua Li, Jing Zhang, Yongfeng Zhou, Qi Gao, Rui Wang, Yurong Fu, Lianwen Zheng, Hao Yu   +7 more
semanticscholar   +1 more source

HO-1 overexpression and underexpression: Clinical implications

Archives of Biochemistry and Biophysics, 2019
In this review we examine the effects of both over- and under-production of heme oxygenase-1 (HO-1) and HO activity on a broad spectrum of biological systems and on vascular disease. In a few instances e.g., neonatal jaundice, overproduction of HO-1 and increased HO activity results in elevated levels of bilirubin requiring clinical intervention with ...
George S, Drummond, Jeffrey, Baum, Menachem, Greenberg, David, Lewis, Nader G, Abraham   +4 more
openaire   +2 more sources

Recipient HO-1 inducibility is essential for posttransplant hepatic HO-1 expression and graft protection: From bench-to-bedside [PDF]

American Journal of Transplantation, 2019
By documenting potent antioxidative and anti-inflammatory functions, preclinical studies encourage heme oxygenase-1 (HO-1)-inducing regimens in clinical orthotopic liver transplantation (OLT). We aimed to determine the importance of recipient-derived HO-1 in murine and human OLTs. Hepatic biopsies from 51 OLT patients were screened for HO-1 expression (
Shoichi Kageyama, Hirofumi Hirao, Kojiro Nakamura, Bibo Ke, Min Zhang, Takahiro Ito, Antony Aziz, Damla Oncel, Fady M. Kaldas, Ronald W. Busuttil, Rebecca A. Sosa, Elaine F. Reed, Jesus A. Araujo, Jerzy W. Kupiec-Weglinski   +13 more
openaire   +5 more sources

Mevastatin-Induced AP-1-Dependent HO-1 Expression Suppresses Vascular Cell Adhesion Molecule-1 Expression and Monocyte Adhesion on Human Pulmonary Alveolar Epithelial Cells Challenged with TNF-α

Biomolecules, 2020
Mevastatin (MVS) has been previously shown to induce heme oxygenase (HO)-1 expression through Nox/ROS-dependent PDGFRα/PI3K/Akt/Nrf2/ARE axis in human pulmonary alveolar epithelial cells (HPAEpiCs).
Chuen-Mao Yang, Chih-Chung Lin, Chien-Chung Yang, Rou-Ling Cho, Li-Der Hsiao   +4 more
doaj   +1 more source