G3: Genes, Genomes, Genetics, 2016 Upon fertilization Chlamydomonas reinhardtii zygotes undergo a program of differentiation into a diploid zygospore that is accompanied by transcription of hundreds of zygote-specific genes.
Takashi Hamaji +3 more
doaj +1 more source
The Homeodomain Iroquois Proteins Control Cell Cycle Progression and Regulate the Size of Developmental Fields. [PDF]
PLoS Genetics, 2015 During development, proper differentiation and final organ size rely on the control of territorial specification and cell proliferation. Although many regulators of these processes have been identified, how both are coordinated remains largely unknown ...
Natalia Barrios +3 more
doaj +1 more source
The early expansion and evolutionary dynamics of POU class genes. [PDF]
, 2014 The POU genes represent a diverse class of animal-specific transcription factors that play important roles in neurogenesis, pluripotency, and cell-type specification. Although previous attempts have been made to reconstruct the evolution of the POU class,
Gates, Ruth D +2 more
core +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
The proline rich homeodomain protein PRH/Hhex forms stable oligomers that are highly resistant to denaturation. [PDF]
PLoS ONE, 2012 Many transcription factors control gene expression by binding to specific DNA sequences at or near the genes that they regulate. However, some transcription factors play more global roles in the control of gene expression by altering the architecture of ...
Anshuman Shukla +3 more
doaj +1 more source
MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity [PDF]
, 1998 We have investigated the genetic circuitry underlying the determination of neuronal identity, using mammalian peripheral autonomic neurons as a model system.
Anderson, David J. +2 more
core
Extending the dynamic range of transcription factor action by translational regulation
, 2015 A crucial step in the regulation of gene expression is binding of transcription factor (TF) proteins to regulatory sites along the DNA. But transcription factors act at nanomolar concentrations, and noise due to random arrival of these molecules at their
Bialek, William +3 more
core +1 more source
In planta localisation patterns of MADS domain proteins during floral development in Arabidopsis thaliana [PDF]
, 2009 Background: MADS domain transcription factors play important roles in various developmental processes in flowering plants. Members of this family play a prominent role in the transition to flowering and the specification of floral organ identity. Several
Angenent, G.C. +5 more
core +3 more sources
ParaHox Genes Revisited: From Gut Patterning to Integrated Axial and Neural Organization in Rotifera
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.In rotifers, ParaHox genes show a dispersed genomic organization, with Xlox absent across gnathiferans. Exclusive neuronal expression of Gsx and Cdx reveals that ancestral ParaHox genes coordinated neural and epithelial development beyond gut patterning, suggesting an integrated role in early bilaterian body plan organization.
Andreas C. Fröbius +2 more
wiley +1 more source
Biology Open, 2013 Summary The basic helix–loop–helix factor Myod initiates skeletal muscle differentiation by directly and sequentially activating sets of muscle differentiation genes, including those encoding muscle contractile proteins.
Zizhen Yao +3 more
doaj +1 more source