Huangkui Capsule in Combination with Leflunomide Improves Immunoglobulin A Nephropathy by Inhibiting the TGF-β1/Smad3 Signaling Pathway [PDF]
Clinics, 2021 OBJECTIVES: To investigate the efficacy and potential molecular mechanism of Huangkui capsule in combination with leflunomide (HKL) for the treatment of immunoglobulin A nephropathy (IgAN) METHODS: IgAN rat models were constructed by treating rats with ...
Shuwen Pei
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Inhibition of Akt/mTOR/p70S6K Signaling Activity With Huangkui Capsule Alleviates the Early Glomerular Pathological Changes in Diabetic Nephropathy [PDF]
Frontiers in Pharmacology, 2018 Huangkui capsule (HKC), a Chinese modern patent medicine extracted from Abelmoschus manihot (L.) medic, has been widely applied to clinical therapy in the early diabetic nephropathy (DN) patients.
Qi-Jun Fang, Zi-Yue Wan, Tu Yue
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Integrating proteomics and network pharmacology to explore the relevant mechanism of Huangkui capsule in the treatment of chronic glomerulonephritis [PDF]
Frontiers in PharmacologyIntroductionChronic glomerulonephritis (CGN) is a common glomerular disease with multifactorial pathogenesis. Huangkui capsule (HKC), a traditional Chinese herbal formulation, demonstrates therapeutic potential in CGN; however, its molecular mechanisms ...
Chang Qing Wen +5 more
doaj +4 more sources
Huobahuagen tablet improves renal function in diabetic kidney disease: a real-world retrospective cohort study [PDF]
Frontiers in Endocrinology, 2023 ObjectiveWe aimed to explore the value of Huobahuagen tablet (HBT) in improving decreased renal function for patients with diabetic kidney disease (DKD) over time.MethodsThis was a single-center, retrospective, real-world study on eligible 122 DKD ...
Ying Tan +11 more
doaj +4 more sources
Huangkui Capsule Ameliorates Renal Fibrosis in a Unilateral Ureteral Obstruction Mouse Model Through TRPC6 Dependent Signaling Pathways [PDF]
Frontiers in Pharmacology, 2020 Renal fibrosis is the final common pathological manifestation of almost all progressive chronic kidney diseases (CKD). Transient receptor potential canonical (TRPC) channels, especially TRPC3/6, were proposed to be essential therapeutic targets for ...
Zhengyu Cao, Bo-Yang Yu, Yu Bo-Yang
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Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy [PDF]
Frontiers in Pharmacology, 2023 Introduction: Huangkui capsule (HKC) is made from the ethanol extract of Abelmoschus manihot (L.) Medik [Malvaceae; abelmoschi corolla] and received approval from the China Food and Drug Administration (Z19990040) in 1999.
Zhipeng Diao +10 more
doaj +4 more sources
Effects of Abelmoschus manihot (L.) and its combination with irbesartan in the treatment of diabetic nephropathy via the gut–kidney axis [PDF]
Frontiers in PharmacologyBackgroundClinical observations have recently shown that Abelmoschus manihot (L.) in the form of Huangkui capsule (HKC) and in combination with irbesartan (EB) is an effective therapy for diabetic nephropathy (DN) in patients with type 2 diabetes (T2D ...
Hongmei Yu +10 more
doaj +4 more sources
Uncovering the mechanism of Huangkui capsule in the treatment of diabetic kidney disease based on network pharmacology and experimental validation [PDF]
Scientific ReportsDiabetic kidney disease (DKD) is a main complication of diabetes mellitus. experimental in vitro validation and Network pharmacology were used in this study to explore the potential mechanism of Huangkui capsules (HKC) in treating DKD.
Ziwei Li +2 more
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Total flavonoids from Abelmoschus manihot (L.) improve diabetes nephropathy by regulating the gut–kidney axis [PDF]
Frontiers in MedicineBackgroundA recent clinical study demonstrated that Huangkui capsule (with its bioactive constituents being total flavones extracted from Abelmoschus manihot (L.), TFA) combined with irbesartan provides effective therapy for type 2 diabetes (T2D ...
Hongmei Yu +5 more
doaj +3 more sources
Evaluation of the efficacy of Abelmoschus manihot (L.) on diabetic nephropathy by analyzing biomarkers in the glomeruli and proximal and distal convoluted tubules of the kidneys [PDF]
Frontiers in Pharmacology, 2023 Introduction: As a traditional Chinese medicine, Abelmoschus manihot (L.) in the form of Huangkui (HK) capsule has been used as a medication for kidney diseases, including diabetic nephropathy (DN), in China.
Hongmei Yu +11 more
doaj +2 more sources