Microbial Biotechnology, 2023 Huangkui capsule (HKC), a traditional Chinese medicine, has been used for medication of kidney diseases, including diabetic nephropathy (DN). The current study aimed to evaluate the effects of HKC in the modulation of gut microbiota and the amelioration ...
Ruiya Shi +7 more
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Huangkui capsule mitigates diabetic nephropathy via epigenetic therapy effects [PDF]
Frontiers in PharmacologyBackgroundHuangkui capsule (HKC), a Chinese herbal medicine derived from Abelmoschus manihot (L.) ethanol extract, has clinical efficacy against diabetic nephropathy (DN).
Yihong Yu +7 more
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Differential efficacy and anti-inflammatory mechanisms of Bailing Preparations versus Huangkui Capsules combined with SGLT-2 inhibitors for diabetic kidney disease: a network meta-analysis and GRADE assessment [PDF]
Frontiers in PharmacologyBackgroundWhile sodium-glucose cotransporter 2 (SGLT-2) inhibitors serve as the cornerstone of therapy for diabetic kidney disease (DKD), a specific subset of patients continues to face residual risks, manifested as persistent proteinuria or declining ...
Xinyu Li, Xiao Yuan, Zhiyu Wu
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Clinical efficacy, safety, and cost of nine Chinese patent medicines combined with ACEI/ARB in the treatment of early diabetic kidney disease: A network meta-analysis [PDF]
Frontiers in Pharmacology, 2022 Objectives: To evaluate and compare the efficacy, safety, and cost of nine Chinese patent medicines (CPMs) combined with angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) in treating early diabetic kidney disease (DKD ...
Jiarong Liu, Xuehan Zhang, Gaosi Xu
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Therapeutic potential of Abelmoschus manihot: mechanisms of action and clinical use in traditional Chinese medicine formulas [PDF]
Frontiers in PharmacologyAbelmoschus manihot (L.) Medicus (AM), commonly known as Huangshukui in China, is a traditional medicinal herb. Its flowers serve as the primary active component of Huangkui Capsule (HKC), which has demonstrated therapeutic potential in various ...
Chu Xue +8 more
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Huangkui capsule combined with finerenone attenuates diabetic nephropathy by regulating the JAK2/STAT3 signaling pathway based on network pharmacology, molecular docking, and experimental verification [PDF]
Frontiers in PharmacologyIntroductionDiabetic nephropathy (DN) is a serious complication of diabetes with limited therapeutic options. Although Huangkui capsule (HKC) and finerenone individually show potential in DN management, their combined mechanism remains unclear.
Xuanke Liu +6 more
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Research progress in the treatment of lipid metabolism disorder in patients with diabetic kidney disease by the integrated traditional Chinese and Western medicine [PDF]
Frontiers in EndocrinologyDiabetic kidney disease (DKD) is one of the most common and severe chronic microvascular complications of diabetes mellitus (DM). The pathogenesis of DKD is complex, and lipid metabolism disorders play an important role in the pathogenesis of DKD.
Lingli Sheng +6 more
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Trials, 2017 Background IgA nephropathy (IgAN) is one of the most common primary glomerular diseases worldwide, but effective therapy remains limited and many patients progress to end-stage renal disease (ESRD).
Ping Li +11 more
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Traditional Chinese medicine improved diabetic kidney disease through targeting gut microbiota
Pharmaceutical BiologyContext Diabetic kidney disease (DKD) affects nearly 40% of diabetic patients, often leading to end-stage renal disease that requires renal replacement therapies, such as dialysis and transplantation.
Xia-Qing Wu +6 more
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Traditional Chinese medicine in the treatment of diabetic kidney disease: the mechanisms of signaling pathways regulations [PDF]
Frontiers in EndocrinologyDiabetic kidney disease (DKD) represents a diabetes-driven microvascular complication characterized by renal physiological and metabolic disorders and is considered a top-ranking trigger of progression to end-stage renal disease and death in diabetic ...
Wencan Li +7 more
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