Extended release huperzine for the treatment of idiopathic epilepsy in dogs – a Case Report [PDF]
Frontiers in Veterinary ScienceHuperzine is a naturally occurring alkaloid derived from the Chinese clubmoss Huperzia serrata. It is a potent acetylcholinesterase inhibitor, among other properties, and has demonstrated protection against induced seizures in a mouse model of Dravet’s ...
Kylie L. Grant, Sam N. Long
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Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage through endothelial cell pyroptosis inhibition [PDF]
Acta Biochimica et Biophysica SinicaSpontaneous subarachnoid hemorrhage (SAH) is a kind of hemorrhagic stroke which causes neurological deficits in survivors. Huperzine A has a neuroprotective effect, but its role in SAH is unclear.
Hu Qiang +5 more
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Huperzine A suppresses absence seizures in the genetic absence epilepsy rat from Strasbourg (GAERS) model of genetic generalized epilepsy with absence seizures [PDF]
Epilepsia OpenObjective We evaluated huperzine A treatment in the Genetic Absence Epilepsy Rat from Strasbourg (GAERS) model of genetic generalized epilepsy (GGE) with absence seizures.
Pablo M. Casillas‐Espinosa +6 more
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Antioxidant, Anti-Inflammatory, and Chemical Composition Analysis of In Vitro Huperzia serrata Thallus and Wild Huperzia serrata [PDF]
MoleculesHuperzine A is a preferred treatment option for Alzheimer’s disease. Huperzia serrata (Thunb. ex Murray) Trev. (H. serrata) has garnered significant attention for its ability to produce Huperzine A (HupA). However, natural populations of wild H. serrata (
Yongchun Huang +7 more
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Phyllosphere mycobiome in two Lycopodiaceae plant species: unraveling potential HupA-producing fungi and fungal interactions [PDF]
Frontiers in Plant ScienceHuperzine A (HupA), a lycopodium alkaloid with therapeutic potential for neurodegenerative diseases such as Alzheimer’s disease, is found exclusively in some species of the Huperzioideae subfamily of Lycopodiaceae.
Liqun Lin +6 more
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Co-cultivation Serratia marcescens with Trichoderma harzianum for improving production of Huperzine A [PDF]
Applied Microbiology and BiotechnologyPlant-derived (−)-Huperzine A (HupA), the bioactive enantiomer of the acetylcholinesterase inhibitor used for Alzheimer’s disease (AD) therapy, is limited by the scarcity of Huperzia serrata (HS), while chemically synthesized (+)-HupA is clinically ...
Han Wen-Xia +9 more
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Examining the interactome of huperzine A by magnetic biopanning. [PDF]
PLoS ONE, 2012 Huperzine A is a bioactive compound derived from traditional Chinese medicine plant Qian Ceng Ta (Huperzia serrata), and was found to have multiple neuroprotective effects.
Wei Guo +8 more
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The pharmacology and therapeutic potential of (-)-huperzine A
Journal of Experimental Pharmacology, 2012 Maung Kyaw Moe Tun, Seth B HerzonDepartment of Chemistry, Yale University, New Haven, CT, USAAbstract: (–)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss.
Tun MK, Herzon SB
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Exploring the molecular mechanisms of huperzine a in the treatment of rosacea through network pharmacology, machine learning, and molecular dynamics simulations [PDF]
Frontiers in PharmacologyIntroductionRosacea is a common chronic inflammatory skin disorder and dysregulation of neuroimmune functions and neurovascular loops play critical roles in the development of rosacea.
Xin Luo +3 more
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Synthetic approaches towards huperzine A and B [PDF]
ARKIVOC, 2013 Huperzine A and B are potent acetylcholinesterase inhibitors and promising against Alzheimer's disease. Completed and formal total syntheses of these medically relevant alkaloids are presented and discussed.
Shariar Md. Abu Sohel, Till Opatz
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