Isolation and purification of Huperzine A
浙江大学学报. 农业与生命科学版, 2002 Technique of isolation and purification of Huperzine A from Huperzia serrata (Thunb) Trev. was studied in this paper. To get rid of some pigments and other impurities, some of chemical techniques for separation such as extraction with organic acid ...
SHEN Sheng-rong +3 more
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Systematic Investigations of the Huperzine A—Producing Endophytic Fungi of Huperzia serrata in China and Fermentation Optimization Using OSMAC Strategy [PDF]
MoleculesHuperzine A (HupA) can alleviate Alzheimer’s disease due to its reversible inhibition of acetylcholinesterase (AChE). The chemical synthesis and plant extraction of HupA is plagued by route complexity and resource scarcity, respectively.
Wei Li +3 more
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Acta Societatis Botanicorum Poloniae, 2013 This study presents a protocol for a fast and effective in vitro axenic culture of Huperzia selago (Huperziaceae Rothm.) sporophytes, a club moss which is a source of huperzine A, an alkaloid of a considerable therapeutic potential extensively ...
Wojciech J. Szypuła +2 more
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Pharmacological treatments for vascular dementia: a systematic review and Bayesian network meta-analysis [PDF]
Frontiers in PharmacologyBackgroundVascular dementia (VaD) is one of the most prevalent, burdensome, and costly forms of dementia. Pharmacological treatment is often the first-line choice for clinicians; however, there is a paucity of comparative information regarding the ...
Chun Dang +6 more
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Biosynthesis of plant neuroactive alkaloids treating Alzheimer’s disease [PDF]
Frontiers in PharmacologyQuanyu Yin, Zhengkang Zhu, Mengquan Yang
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Return to Spontaneous Circulation in a Patient With Cholinergic Syndrome at the Emergency Department of Buea Regional Hospital, Cameroon. [PDF]
Clin Case RepABSTRACT With the increasing misuse of herbal treatment and pesticides, cases of cholinergic syndrome following herbal treatment or organophosphate poisoning have become increasingly common in our milieu. However, when advanced, mortality is high. We report the successful management of a case involving a 54‐year‐old African female with a known history ...
Nteungue BBK +3 more
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Huperzine A protects against traumatic brain injury through anti-oxidative effects via the Nrf2-ARE pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Traumatic brain injury (TBI) is a prominent health problem worldwide and it may lead to cognitive dysfunction, disability, and even death. To date, there is no effective treatment for TBI.
Zhengrong Mei +4 more
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Alzheimer's Disease: The Current and Emerging Treatment Approaches. [PDF]
Behav NeurolAlzheimer’s disease (AD) is a chronic progressive neurodegenerative disease characterized by amyloid β (Aβ) plaques and neurofibrillary tangles (NFTs) as its main pathological features. It mainly manifests as cognitive dysfunction, and its pathological process may occur before symptom onset.
Pang R +9 more
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Pharmaceutical Biology, 2023 Context Alkaloid-enriched extract of Huperzia serrata (Thunb.) Trevis (Lycopodiaceae) (HsAE) can potentially be used to manage neuronal disorders.Objective This study determines the anti-neuroinflammatory effects of HsAE on lipopolysaccharide (LPS ...
Thu Kim Dang +8 more
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De novo RNA sequencing and transcriptome analysis of Colletotrichum gloeosporioides ES026 reveal genes related to biosynthesis of huperzine A. [PDF]
PLoS ONE, 2015 Huperzine A is important in the treatment of Alzheimer's disease. There are major challenges for the mass production of huperzine A from plants due to the limited number of huperzine-A-producing plants, as well as the low content of huperzine A in these ...
Guowei Zhang +10 more
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