Results 21 to 30 of about 4,132 (213)

Integration of System Biology Tools to Investigate Huperzine A as an Anti-Alzheimer Agent

Frontiers in Pharmacology, 2021
Aim: The present study aimed to investigate huperzine A as an anti-Alzheimer agent based on the principle that a single compound can regulate multiple proteins and associated pathways, using system biology tools.Methodology: The simplified molecular ...
Pukar Khanal, Farshid Zargari, Farshid Zargari, Bahareh Farasati Far, Dharmendra Kumar, Mogana R, Yasir K. Mahdi, Najwan K. Jubair, Shailendra K. Saraf, Parveen Bansal, Ranjit Singh, Malarvili Selvaraja, Yadu Nandan Dey   +12 more
doaj   +1 more source

Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons. [PDF]

PLoS ONE, 2015
Considerable studies indicate huperzine A is a promising natural product to suppress neuronal damages induced by β-amyloid (Aβ), a key pathogenic event in the Alzheimer's disease (AD).
Yun Lei, Ling Yang, Chun Yan Ye, Ming Yan Qin, Huai Yu Yang, Hua Liang Jiang, Xi Can Tang, Hai Yan Zhang   +7 more
doaj   +1 more source

Comparative efficacy of pharmacotherapy and non‐pharmacotherapy for treating Alzheimer's disease: A systematic review and network meta‐analysis for cognitive, behavior and functional outcomes [PDF]

Alzheimers Dement
Abstract Importance Alzheimer's disease (AD), the most prevalent form of dementia, contributes significantly to global disability. Pharmacotherapies (PTs) often have adverse effects, while diverse non‐pharmacotherapies (NPTs) lack comprehensive comparative evaluations against PTs.
Boongird C, Tearneukit W, Wongpipathpong W, Suthutvoravut U, Thongpan M, Pongsettakul N, McKay G, Rattanasiri S, Anothaisintawee T, Thakkinstian A.   +9 more
europepmc   +2 more sources

Rapid Structural Analysis of Natural Products Using MicroED. [PDF]

Small
The cryoEM method, MicroED used for rapid analysis and structure determination of natural products that remained unattainable by other structural biology methods ABSTRACT Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.
Lin J, Paz O, Unge J, Gonen T.
europepmc   +2 more sources

Huperzine A for vascular dementia [PDF]

Cochrane Database of Systematic Reviews, 2008
Huperzine A, a form of herbal medicine, has been considered as an alternative treatment for vascular dementia (VaD) in China.To assess the efficacy and safety of Huperzine A in patients with vascular dementia.The Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (CDCIG) was searched on 7 July 2008 using the terms: huperzi ...
Zilong, Hao, Ming, Liu, Zhiqin, Liu, Donghao, Lv   +3 more
openaire   +2 more sources

Huperzine A for mild cognitive impairment [PDF]

Cochrane Database of Systematic Reviews, 2010
Mild cognitive impairment (MCI) has been proposed as a condition of intermediate symptomatology between the cognitive changes of ageing and fully developed symptoms of dementia. Treatment in the stages of MCI may delay the deterioration of cognitive impairment and delay the progression to dementia. Currently, the treatments for Alzheimer's disease have
Jirong, Yue, Bi Rong, Dong, Xiufang, Lin, Ming, Yang, Hong Mei, Wu, Taixiang, Wu   +5 more
openaire   +2 more sources

Loss of Pathogenicity and Evidence of Horizontal Gene Transfer in Colletotrichum gloeosporioides From a Medicinal Plant. [PDF]

Mol Plant Pathol
A Colletotrichum gloeosporioides strain from Huperzia serrata lacks key pathogenicity genes CgDN3 and cap20 and has fewer pelB, pnl and pg genes. pksIII, for synthesis of huperzine A, was probably acquired by the host plant from the fungus. ABSTRACT Colletotrichum gloeosporioides is a major agricultural pathogen of crops that has also been identified ...
Yue X, Yang J, Qi J, Gao S, Huo Q, Guo X, Guo H, Luo J, Wang Y, Zhao Y, Liu R, Wang H, Yi S, Fu Y, Ji X, Wei Y, He W, Guo B.   +17 more
europepmc   +2 more sources

RNA-seq of aboveground sporophyte’s transcriptome of Huperzia serrata and transcriptional understanding of early steps associated with huperzine biosynthesis in forest

Current Plant Biology, 2020
Chinese toothed clubmoss (Huperzia serrata) is a primitive fern native in certain types of forests. It is severely endangered in China due to its difficult propagation and massive hunting for huperzine A to improve and prevent Alzheimer’s disease.
Qing-Zhong Peng, Hua Long, Ci Du, Jing Li, De-Yu Xie   +4 more
doaj   +1 more source

Huperzine A attenuates nonalcoholic fatty liver disease by regulating hepatocyte senescence and apoptosis: an in vitro study [PDF]

PeerJ, 2018
Objective This study was undertaken to detect if free fatty acids (FFA) induce hepatocyte senescence in L-02 cells and if huperzine A has an anti-aging effect in fatty liver cells.
Xiao-na Hu, Jiao-feng Wang, Yi-qin Huang, Zheng Wang, Fang-yuan Dong, Hai-fen Ma, Zhi-jun Bao   +6 more
doaj   +2 more sources

Beyond Cholinesterase Inhibition. Anti-Inflammatory Role and Pharmacological Profile of Current Drug Therapy for Alzheimer's Disease [PDF]

, 2016
Inflammation is a common response of an individual against either exogenous or endogenous damage. The role of inflammation and of inflammatory cells recently emerged also in the pathogenesis of neurodegenerative disorders. Experimental evidences show how
GIUBILEI, Franco
core   +1 more source