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Hypervirulent Klebsiella pneumoniae (hvKp): Overview, Epidemiology, and Laboratory Detection

Pathogens and Immunity
Klebsiella pneumoniae (Kp) is a Gram-negative pathogen responsible for both hospital- and community-acquired infections. Kp is classified into 2 distinct pathotypes: classical K. pneumoniae (cKp) and hypervirulent K. pneumoniae (hvKp).
Dania Al Ismail, Edgar I. Campos-Madueno, Valentina Donà, Andrea Endimiani   +3 more
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A Step Forward in Hypervirulent Klebsiella pneumoniae Diagnostics

Emerging Infectious Diseases
Hypervirulent Klebsiella pneumoniae (hvKp) can cause life-threatening infections in healthy community members. HvKp infections often involve multiple sites, some of which are unusual for classical K.
Thomas A. Russo, Francois Lebreton, Patrick T. McGann   +2 more
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Targeting carbapenem-resistant and hypervirulent Klebsiella pneumoniae: in vitro evaluation of cefepime/zidebactam, aztreonam/avibactam, imipenem/relebactam, and meropenem/vaborbactam

BMC Infectious Diseases
Background The emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) is a growing concern because of the high mortality rates and limited treatment options.
Yi Li, Yulian Li, Xun Jia, Huinan Mao, Dan Li, Jie Zhang   +5 more
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Emergence of Multidrug Resistant Hypervirulent ST23 Klebsiella pneumoniae: Multidrug Resistant Plasmid Acquisition Drives Evolution

Frontiers in Cellular and Infection Microbiology, 2020
BackgroundIn recent years, the emergence of multidrug resistant hypervirulent K. pneumoniae (MDR hvKp) isolates poses severe therapeutic challenge to global public health.
Chaitra Shankar, Jobin John Jacob, Karthick Vasudevan, Rohit Biswas, Abi Manesh, Dhiviya Prabaa Muthuirulandi Sethuvel, Santosh Varughese, Indranil Biswas, Balaji Veeraraghavan   +8 more
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Clinical and Microbiological Characteristics of Invasive and Hypervirulent Klebsiella pneumoniae Infections in a Teaching Hospital in China

Infection and Drug Resistance, 2020
Lijuan Li, Ziyang Yuan, Danna Chen, Xiaoyan Xie, Bashan Zhang Department of Clinical Laboratory, Affiliated Dongguan People’s Hospital, Southern Medical University, Dongguan, Guangdong 523059, People’s Republic of ChinaCorrespondence: Bashan ...
Li L, Yuan Z, Chen D, Xie X, Zhang B
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Genomic insights unveil the plasmid transfer mechanism and epidemiology of hypervirulent Klebsiella pneumoniae in Vietnam

Nature Communications
Hypervirulent Klebsiella pneumoniae (hvKp) is a significant cause of severe invasive infections in Vietnam, yet data on its epidemiology, population structure and dynamics are scarce.
Quynh Nguyen, Yen Thi Phuong Nguyen, Tuyen Thanh Ha, Dung Thi Ngoc Tran, Phat Vinh Voong, Vinh Chau, Phuong Luong Nha Nguyen, Ngan Thi Quynh Le, Lan Phu Huong Nguyen, To Thi Nguyen Nguyen, Tan Van Trinh, Juan J. Carrique-Mas, Stephen Baker, Guy Thwaites, Maia A. Rabaa, Marc Choisy, Hao The Chung, Duy Thanh Pham   +17 more
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Genomic epidemiology of putative hypervirulent Klebsiella pneumoniae species complex in Dutch patients, January–December 2022

Microbiology Spectrum
Hypervirulent Klebsiella pneumoniae species complex (hvKp) can cause invasive infections with spontaneous abscesses, also in previously healthy individuals.
Karuna E. W. Vendrik, Gijs Teunis, Fardau Anema, Fabian Landman, Angela de Haan, Jeroen Bos, Sandra Witteveen, Annelot F. Schoffelen, Sabine C. de Greeff, Ed J. Kuijper, Antoni P. A. Hendrickx, Daan W. Notermans   +11 more
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Five-Biomarker Definition for Hypervirulent Klebsiella pneumoniae Bloodstream Infection and Abscess Complications, Japan, 2022–2024

Emerging Infectious Diseases
Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging cause of invasive infection, but clinical relevance of a 5-biomarker genotypic definition remains unclear. We analyzed 207 episodes of K.
Naoki Watanabe, Tomohisa Watari, Yoshihito Otsuka, Tomoh Matsumiya   +3 more
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High prevalence of hypervirulent Klebsiella pneumoniae infection in the genetic background of elderly patients in two teaching hospitals in China

Infection and Drug Resistance, 2018
Chao Liu,1 Jiaojiao Shi,2 Jun Guo3,4 1Department of Respiratory Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, China-Japan Friendship Hospital, Beijing, China; 2Department of Respiratory Medicine, Peking University Third ...
Liu C, Shi J, Guo J
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高黏液性肺炎克雷伯菌的临床特征及分子分型

Zhongguo shiyan zhenduanxue, 2022
目的 分析高黏液性肺炎克雷伯菌（hvKP）的临床特征及毒力基因携带情况，方法 对临床分离的肺炎克雷伯菌（KP），通过黏液拉丝试验筛选出hvKP，采用PCR方法检测hvKP的毒力基因和荚膜血清型，采用脉冲场凝胶电泳（PFGE）和多位点序列分型（MLST）方法对hvKP进行分子分型。结果 在631株KP中，共分离hvKP 56株，分离率为8.9%，主要来自于急诊病房、肝胆外科病房；穿刺液、血液和脓液为hvKP的主要标本来源；hvKP的荚膜血清型以K1和K2为主，二者占60.7 ...
王英英, 武彬蔚, 李莉
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