Results 1 to 10 of about 1,927 (113)

Targeting carbapenem-resistant and hypervirulent Klebsiella pneumoniae: in vitro evaluation of cefepime/zidebactam, aztreonam/avibactam, imipenem/relebactam, and meropenem/vaborbactam [PDF]

BMC Infectious Diseases
Background The emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) is a growing concern because of the high mortality rates and limited treatment options.
Yi Li, Yulian Li, Xun Jia, Huinan Mao, Dan Li, Jie Zhang   +5 more
doaj   +2 more sources

Clinical and genomic characterization of hypervirulent Klebsiella pneumoniae (hvKp) infections via passive surveillance in Southern California, 2020–2022

Frontiers in Microbiology, 2022
Hypervirulent Klebsiella pneumoniae (hvKp) is more invasive and virulent than classical K. pneumoniae, and requires specialized treatment. To raise clinical awareness, this study determined the prevalence, clinical characteristics, and genomic ...
Edwin Kamau, Elke S Bergmann-Leitner, Shangxin Yang   +2 more
exaly   +3 more sources

Neutrophil extracellular traps (NETs)-mediated killing of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) are impaired in patients with diabetes mellitus

Virulence, 2020
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) have been reported in recent years across Asian countries and pose a serious threat to public health. Neutrophils represent the first line of defense against numerous infectious pathogens,
Longyang Jin, Yudong Liu, Ruobing Wang   +2 more
exaly   +2 more sources

Genomic epidemiology of putative hypervirulent Klebsiella pneumoniae species complex in Dutch patients, January–December 2022 [PDF]

Microbiology Spectrum
Hypervirulent Klebsiella pneumoniae species complex (hvKp) can cause invasive infections with spontaneous abscesses, also in previously healthy individuals.
Karuna E. W. Vendrik, Gijs Teunis, Fardau Anema, Fabian Landman, Angela de Haan, Jeroen Bos, Sandra Witteveen, Annelot F. Schoffelen, Sabine C. de Greeff, Ed J. Kuijper, Antoni P. A. Hendrickx, Daan W. Notermans   +11 more
doaj   +2 more sources

Detection of hypervirulent Klebsiella pneumoniae (hvKp) strains directly from spiked blood cultures using a commercial Loop-Mediated isothermal amplification (LAMP) assay

Annals of Clinical Microbiology and Antimicrobials
Background Hypervirulent K. pneumoniae (hvKp) strains are characterized by their enhanced ability to evade immune responses and disseminate systemically.
Domingo Fernández Vecilla, Alain A Ocampo-Sosa, Ocampo-Sosa Alain   +2 more
exaly   +2 more sources

Epidemiological and characteristic differences of hypervirulent and classical Klebsiella pneumoniae: a clinical and genomic study in Southern China during the COVID-19 pandemic [PDF]

Frontiers in Cellular and Infection Microbiology
IntroductionHypervirulent Klebsiella pneumoniae (hvKp) has emerged as a significant public health threat owing to its ability to cause invasive infections.
Yushan Jiang, Yushan Jiang, Yushan Jiang, Nianqing Kong, Zhuolin Li, Weiling Wu, Yifei Xie, Zhujun Zeng, Zhujun Zeng, Tingting Peng, Chenguang Shen, Chenguang Shen, Chenguang Shen, Shi Ouyang   +13 more
doaj   +2 more sources

The human gut serves as a reservoir of hypervirulent Klebsiella pneumoniae

Gut Microbes, 2022
Hypervirulent Klebsiella pneumoniae (hvKp) can cause serious infections and has been increasingly reported clinically. However, we still lack the knowledge to what degree hvKp colonize the community. In this study, we investigated colonization of hvKp in
Jing Yang, Yi Li, Na Tang, Juan Li, Juan Zhou, Shan Lu, Gui Zhang, Yuqin Song, Chao Wang, Jin Zhong, Jianguo Xu, Jie Feng   +11 more
doaj   +1 more source

Identification of hypervirulent Klebsiella pneumoniae based on biomarkers and Galleria mellonella infection model

BMC Microbiology, 2023
Background Currently, clinical laboratories lack an effective method to differentiate between classical Klebsiella pneumoniae (cKP) and hypervirulent Klebsiella pneumoniae (hvKP) strains, leading to delays in diagnosing and treating hvKP infections ...
Dongmei Mai, Anqi Wu, Ran Li, Donghao Cai, Huichun Tong, Nan Wang, Junqing Tan   +6 more
doaj   +1 more source

Outer membrane vesicles-transmitted virulence genes mediate the emergence of new antimicrobial-resistant hypervirulent Klebsiella pneumoniae

Emerging Microbes and Infections, 2022
Hypervirulent Klebsiella pneumoniae (hvKp) is a notorious clinical pathogen that is more likely to cause severe primary and metastatic abscesses. The dissemination of antimicrobial-resistant hvKp isolates has been reported worldwide, posing a great ...
Yuneng Hua, Jingyu Wang, Mei Huang, Yiyi Huang, Ruyi Zhang, Fan Bu, Biao Yang, Juanjiang Chen, Xiaomin Lin, Xiumei Hu, Lei Zheng, Qian Wang   +11 more
doaj   +1 more source

Clinical and microbiological characteristics of hypervirulent Klebsiella pneumoniae (hvKp) in a hospital from North China

Journal of Infection in Developing Countries, 2020
Introduction: The clinical and molecular characteristics of hypervirulent Klebsiella pneumoniae (hvKp) in various provinces of China have been reported, however, there have been few reports in Hebei Province, North China.
Yan Yang, Jian-Hua Liu, Xin-Xin Hu, Wei Zhang, Tong-Ying Nie , Xin-Yi Yang, Xiu-Kun Wang, Cong-Ran Li, Xue-Fu You   +8 more
doaj   +1 more source