Clinical and genomic characterization of hypervirulent Klebsiella pneumoniae (hvKp) infections via passive surveillance in Southern California, 2020–2022 [PDF]
Frontiers in Microbiology, 2022 Hypervirulent Klebsiella pneumoniae (hvKp) is more invasive and virulent than classical K. pneumoniae, and requires specialized treatment. To raise clinical awareness, this study determined the prevalence, clinical characteristics, and genomic ...
Edwin Kamau
exaly +8 more sources
Detection of hypervirulent Klebsiella pneumoniae (hvKp) strains directly from spiked blood cultures using a commercial Loop-Mediated isothermal amplification (LAMP) assay [PDF]
Annals of Clinical Microbiology and AntimicrobialsBackground Hypervirulent K. pneumoniae (hvKp) strains are characterized by their enhanced ability to evade immune responses and disseminate systemically.
Alain Ocampo-Sosa
exaly +6 more sources
Neutrophil extracellular traps (NETs)-mediated killing of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) are impaired in patients with diabetes mellitus [PDF]
Virulence, 2020 Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) have been reported in recent years across Asian countries and pose a serious threat to public health. Neutrophils represent the first line of defense against numerous infectious pathogens,
Longyang Jin +2 more
exaly +4 more sources
The human gut serves as a reservoir of hypervirulent Klebsiella pneumoniae
Gut Microbes, 2022 Hypervirulent Klebsiella pneumoniae (hvKp) can cause serious infections and has been increasingly reported clinically. However, we still lack the knowledge to what degree hvKp colonize the community. In this study, we investigated colonization of hvKp in
Jing Yang +11 more
doaj +2 more sources
BMC Microbiology, 2023 Background Currently, clinical laboratories lack an effective method to differentiate between classical Klebsiella pneumoniae (cKP) and hypervirulent Klebsiella pneumoniae (hvKP) strains, leading to delays in diagnosing and treating hvKP infections ...
Dongmei Mai +6 more
doaj +2 more sources
Revisiting definitions of hypervirulent and classical Klebsiella pneumoniae through virulence factors and disease phenotype [PDF]
Communications MedicineBackground Hypervirulent Klebsiella pneumoniae (hvKP) has been described as an invasive syndrome of liver abscess and metastatic infection in Asia, and this syndrome is emerging globally.
Alfred Lok-Hang Lee +9 more
doaj +2 more sources
Hypervirulent Klebsiella pneumoniae induces liver abscess by promoting neutrophil extracellular trap formation through NLRP3 inflammasome activation [PDF]
Microbiology SpectrumHypervirulent Klebsiella pneumoniae (hvKP) has spread globally, causing severe liver abscesses. Neutrophil extracellular trap formation (NETosis) is an essential defense mechanism of neutrophils. However, the role of pathogenicity and molecular mechanism
Qian Ou +13 more
doaj +2 more sources
Comparative analysis of virulence factors and two-component systems expression in carbapenem-resistant and carbapenem-susceptible Klebsiella pneumoniae isolates at a tertiary hospital in Wenzhou, China [PDF]
Microbiology SpectrumThis study investigated the virulence factors and two-component systems (TCS) expression in carbapenem-resistant Klebsiella pneumoniae (CRKP) and carbapenem-susceptible Klebsiella pneumoniae (CSKP).
Hao Chen +4 more
doaj +2 more sources
Targeting carbapenem-resistant and hypervirulent Klebsiella pneumoniae: in vitro evaluation of cefepime/zidebactam, aztreonam/avibactam, imipenem/relebactam, and meropenem/vaborbactam [PDF]
BMC Infectious DiseasesBackground The emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) is a growing concern because of the high mortality rates and limited treatment options.
Yi Li +5 more
doaj +2 more sources
Emerging Microbes and Infections, 2022 Hypervirulent Klebsiella pneumoniae (hvKp) is a notorious clinical pathogen that is more likely to cause severe primary and metastatic abscesses. The dissemination of antimicrobial-resistant hvKp isolates has been reported worldwide, posing a great ...
Yuneng Hua +11 more
doaj +1 more source