Results 11 to 20 of about 2,667 (163)

Detection of hypervirulent Klebsiella pneumoniae (hvKp) strains directly from spiked blood cultures using a commercial Loop-Mediated isothermal amplification (LAMP) assay [PDF]

Annals of Clinical Microbiology and Antimicrobials
Background Hypervirulent K. pneumoniae (hvKp) strains are characterized by their enhanced ability to evade immune responses and disseminate systemically.
Domingo Fernández Vecilla, Jorge Rodriguez-Grande, Alain A Ocampo-Sosa   +2 more
exaly   +3 more sources

Clinical and microbiological characteristics of hypervirulent Klebsiella pneumoniae (hvKp) in a hospital from North China [PDF]

Journal of Infection in Developing Countries, 2020
Introduction: The clinical and molecular characteristics of hypervirulent Klebsiella pneumoniae (hvKp) in various provinces of China have been reported, however, there have been few reports in Hebei Province, North China.
Yan Yang, Jian-Hua Liu, Xin-Xin Hu, Wei Zhang, Tong-Ying Nie , Xin-Yi Yang, Xiu-Kun Wang, Cong-Ran Li, Xue-Fu You   +8 more
doaj   +2 more sources

Identification of hypervirulent Klebsiella pneumoniae based on biomarkers and Galleria mellonella infection model

BMC Microbiology, 2023
Background Currently, clinical laboratories lack an effective method to differentiate between classical Klebsiella pneumoniae (cKP) and hypervirulent Klebsiella pneumoniae (hvKP) strains, leading to delays in diagnosing and treating hvKP infections ...
Dongmei Mai, Anqi Wu, Ran Li, Donghao Cai, Huichun Tong, Nan Wang, Junqing Tan   +6 more
doaj   +2 more sources

Hypervirulent Klebsiella pneumoniae (hypermucoviscous and aerobactin positive) infection over 6 years in the elderly in China: antimicrobial resistance patterns, molecular epidemiology and risk factor

Annals of Clinical Microbiology and Antimicrobials, 2019
Background The definition of hypervirulent Klebsiella pneumoniae (hvKp), traditionally regarded as hypermucoviscosity, is controversial. However, data based on both phenotype (hypermucoviscous) and genetic (aerobactin) criteria are limited.
Chao Liu, Jun Guo
doaj   +2 more sources

Clinical and Molecular Analysis of ST11-K47 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae: A Strain Causing Liver Abscess

Pathogens, 2022
Klebsiella pneumoniae has been the predominant pathogen of liver abscess, but ST11-K47 carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) has rarely been studied as the causative organism. We identified an ST11-K47 CR-hvKP (HvKp-su1) from
Zhen Cai, Tianye Jia, Mingfang Pu, Shuyong Zhang, Jingxia Zhang, Ronghua Geng, Suming Chen, Yahao Li, Huahao Fan, Yigang Tong, Fen Qu   +10 more
doaj   +2 more sources

Clinical and genomic characterization of hypervirulent Klebsiella pneumoniae (hvKp) infections via passive surveillance in Southern California, 2020–2022 [PDF]

Frontiers in Microbiology, 2022
Hypervirulent Klebsiella pneumoniae (hvKp) is more invasive and virulent than classical K. pneumoniae, and requires specialized treatment. To raise clinical awareness, this study determined the prevalence, clinical characteristics, and genomic ...
Edwin Kamau, Elizabeth L. Ranson, Allison T. Tsan, Elke S. Bergmann-Leitner, Omai B. Garner, Shangxin Yang   +5 more
doaj   +2 more sources

A strategy for controlling Hypervirulent Klebsiella pneumoniae: inhibition of ClpV expression

BMC Microbiology
The emergence and prevalence of hypervirulent Klebsiella pneumoniae (hvKP) have proposed a great challenge to control this infection. Therefore, exploring some new drugs or strategies for treating hvKP infection is an urgent issue for scientific ...
Wenke Liu, Dan Wang, Qiangxing He, Shiwen Cao, Jiaxin Cao, Huajie Zhao, Junwei Cui, Fan Yang   +7 more
doaj   +2 more sources

Interaction of multidrug-resistant hypervirulent Klebsiella pneumoniae with components of human innate host defense

mBio, 2023
Klebsiella pneumoniae is an important cause of healthcare-associated infections worldwide. This opportunistic pathogen, known as classical K. pneumoniae (cKp), typically causes infections in individuals with comorbidities.
Frank R. DeLeo, Adeline R. Porter, Scott D. Kobayashi, Brett Freedman, Mingju Hao, Jianping Jiang, Yi-Tsung Lin, Barry N. Kreiswirth, Liang Chen   +8 more
doaj   +2 more sources

Antimicrobial Resistance Pattern, Pathogenicity and Molecular Properties of Hypervirulent Klebsiella pneumonia (hvKp) among Hospital-Acquired Infections in the Intensive Care Unit (ICU)

Microorganisms, 2023
Hypervirulent Klebsiella pneumoniae (hvKp) is a new emerging variant of K. pneumoniae that is increasingly reported worldwide. The variant hvKp is known to cause severe invasive community-acquired infections such as metastatic meningitis, pyogenic liver ...
Mohanned Talal Alharbi, Mohammed S. Almuhayawi, Mohammed K. Nagshabandi, Muyassar K. Tarabulsi, Mohammed H. Alruhaili, Hattan S. Gattan, Soad K. Al Jaouni, Samy Selim, Awadh Alanazi, Yasir Alruwaili, Shaimaa Mohamed Zaied, Osama Ahmed Faried   +11 more
doaj   +2 more sources

Revisiting definitions of hypervirulent and classical Klebsiella pneumoniae through virulence factors and disease phenotype [PDF]

Communications Medicine
Background Hypervirulent Klebsiella pneumoniae (hvKP) has been described as an invasive syndrome of liver abscess and metastatic infection in Asia, and this syndrome is emerging globally.
Alfred Lok-Hang Lee, Carmen Li, Rita WY Ng, Christopher KC Lai, Peter Chi-Wai Yip, Wing Shan Lee, Lap-Tin Ho, Ingrid Yu-Ying Cheung, Viola Chi-Ying Chow, Margaret Ip   +9 more
doaj   +2 more sources