Results 21 to 30 of about 2,667 (163)

Characteristics of ventilator-associated pneumonia due to hypervirulent Klebsiella pneumoniae genotype in genetic background for the elderly in two tertiary hospitals in China

Antimicrobial Resistance and Infection Control, 2018
Background Aerobactin is a critical factor for the hypervirulent Klebsiella pneumoniae (hvKp), but data for the aerobactin-positive genotype of hvKp in elderly persons with ventilator-associated pneumonia (VAP) is limited. The purpose of this study is to
Chao Liu, Jun Guo
doaj   +2 more sources

Clinical use of tigecycline may contribute to the widespread dissemination of carbapenem-resistant hypervirulent Klebsiella pneumoniae strains

Emerging Microbes and Infections
The emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) poses grave threats to human health. These strains increased dramatically in clinical settings in China in the past few years but not in other parts of the world.
Miaomiao Xie, Lianwei Ye, Kaichao Chen, Qi Xu, Chen Yang, Xiangnan Chen, Edward Wai-Chi Chan, Fuyong Li, Sheng Chen   +8 more
doaj   +2 more sources

Hypervirulent Klebsiella pneumoniae induces liver abscess by promoting neutrophil extracellular trap formation through NLRP3 inflammasome activation [PDF]

Microbiology Spectrum
Hypervirulent Klebsiella pneumoniae (hvKP) has spread globally, causing severe liver abscesses. Neutrophil extracellular trap formation (NETosis) is an essential defense mechanism of neutrophils. However, the role of pathogenicity and molecular mechanism
Qian Ou, Meixia Cheng, Liming Fan, Jingyi Zou, Kaiwen Wang, Ziwen Xie, Weiyu Jiang, Keyi Gong, Jiadong Wang, Ziyan Jiang, Xinyu Zhu, Qiang Wang, Tiejun Zhao, Jiaqi Fang   +13 more
doaj   +2 more sources

Neutrophil extracellular traps (NETs)-mediated killing of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) are impaired in patients with diabetes mellitus

Virulence, 2020
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) have been reported in recent years across Asian countries and pose a serious threat to public health. Neutrophils represent the first line of defense against numerous infectious pathogens,
Longyang Jin, Yudong Liu, Ruobing Wang
exaly   +2 more sources

Microbiological characteristics of hypermucoviscous Klebsiella pneumoniae isolates from different body fluids [PDF]

Journal of Infection in Developing Countries, 2017
Introduction: Reports of hypermucoviscous Klebsiella pneumoniae (hvKP) isolated from fluids other than blood or abscess are rare. The aim of the study was to compare clinical and microbiological characteristics of hvKP found in blood or abscess fluid ...
Xiumei Xiao, Bei Yao, Qingtao Zhou, Jie Zhang   +3 more
doaj   +2 more sources

Comparative analysis of virulence factors and two-component systems expression in carbapenem-resistant and carbapenem-susceptible Klebsiella pneumoniae isolates at a tertiary hospital in Wenzhou, China [PDF]

Microbiology Spectrum
This study investigated the virulence factors and two-component systems (TCS) expression in carbapenem-resistant Klebsiella pneumoniae (CRKP) and carbapenem-susceptible Klebsiella pneumoniae (CSKP).
Hao Chen, Peng Liu, Xiangyang Li, Caixia Liu, Shuo Chen   +4 more
doaj   +2 more sources

A Case Report of Endogenous Endophthalmitis Associated With a Pyogenic Liver Abscess Caused by Hypervirulent Klebsiella pneumoniae. [PDF]

Immun Inflamm Dis
ABSTRACT Objective Pyogenic liver abscess (PLA) caused by hypervirulent Klebsiella pneumoniae (hvKp) may be complicated by endogenous endophthalmitis (EE) and pneumonia. We herein report a case of a Chinese male patient with PLA and bilateral EE caused by hvKp to highlight the severe clinical outcomes of this condition.
Liu C, Song J, Zhao J, Wei B, Wang P, Liu C, Su H, Tong X, Wu D.   +8 more
europepmc   +2 more sources

Molecular Insights Into Hypervirulent Klebsiella pneumoniae: Identification and Correlation of Virulence Determinant [PDF]

Microbiologyopen
Genotypic characterization of 82 clinical K. pneumoniae isolates identified 34 hypervirulent strains. The peg‐344 most strongly associated with hypervirulence (p = 0.0001) but with only 58.8% sensitivity and no signal in over 40% of hvKP isolates, it's a confirmatory marker, not a standalone diagnostic. ABSTRACT Klebsiella pneumoniae is an increasingly
Elkady F, Basher N, Abdulrahman M, Hashem A, Metwally R, Tawab A, Saied E, Ibrahim N, Aufy M.   +8 more
europepmc   +2 more sources

Genomically defined hypervirulent Klebsiella pneumoniae contributed to early-onset increased mortality

Nature Communications
The presence of all five of the virulence-associated genes iucA, iroB, peg-344, rmpA, and rmpA2 is presently the most accurate genomic means for predicting hypervirulent Klebsiella pneumoniae (hvKp-p).
Yunfei Tang, Pengcheng Du, Chunjing Du, Ping Yang, Ning Shen, Thomas A. Russo, Chao Liu   +6 more
doaj   +2 more sources

The human gut serves as a reservoir of hypervirulent Klebsiella pneumoniae

Gut Microbes, 2022
Hypervirulent Klebsiella pneumoniae (hvKp) can cause serious infections and has been increasingly reported clinically. However, we still lack the knowledge to what degree hvKp colonize the community. In this study, we investigated colonization of hvKp in
Jing Yang, Yi Li, Na Tang, Juan Li, Juan Zhou, Shan Lu, Gui Zhang, Yuqin Song, Chao Wang, Jin Zhong, Jianguo Xu, Jie Feng   +11 more
doaj   +1 more source