Results 91 to 100 of about 2,661 (201)
iMeta, Volume 4, Issue 5, October 2025.The global emergence of hypervirulent, carbapenem‐resistant Klebsiella pneumoniae (hvCRKP) poses a paradox: why do such dangerous clones remain geographically confined? By analyzing over 2500 CC23 genomes across 90 years, we uncover a core evolutionary constraint—virulence and resistance rarely coexist without trade‐offs. Potent carbapenemases (blaKPC,
Yuchen Wu +15 more
wiley +1 more source
Infection and Drug Resistance, 2020 Lijuan Li, Ziyang Yuan, Danna Chen, Xiaoyan Xie, Bashan Zhang Department of Clinical Laboratory, Affiliated Dongguan People’s Hospital, Southern Medical University, Dongguan, Guangdong 523059, People’s Republic of ChinaCorrespondence: Bashan ...
Li L, Yuan Z, Chen D, Xie X, Zhang B
doaj
Murine Models of Klebsiella pneumoniae Gastrointestinal Infection
Current Protocols, Volume 5, Issue 8, August 2025.Abstract Klebsiella pneumoniae (Kpn) is a Gram‐negative opportunistic pathogen and a leading cause of hospital‐acquired infections. The gastrointestinal (GI) tract serves as a critical site for Kpn colonization and a reservoir for host‐to‐host spread that primarily occurs through the fecal‐oral route.
Juan D. Valencia‐Bacca +3 more
wiley +1 more source
WGS analysis of hypervirulent and MDR Klebsiella pneumoniae from Vietnam reveales an inverse relationship between resistome and virulome [PDF]
The emergence of Klebsiella (K.) pneumoniae as a leading cause of nosocomial infections in Southeast Asia is of concern. Vietnam has an outstanding position with regard to antimicrobial-resistant (AMR) pathogens and is a hotspot for carbapenem-resistant ...
Brangsch, Hanka +6 more
core +1 more source
MicrobiologyOpen, Volume 14, Issue 4, August 2025.This study identified eight novel sequence types (STs) of hypervirulent Klebsiella pneumoniae using MLST in western Iran. The findings highlight the genetic diversity and public health threat posed by hvKP strains. Phenotypic and genotypic methods, including PCR and MLST, were used to identify hypervirulent Klebsiella pneumoniae isolates in western ...
Mohammad Hossein Haddadi +5 more
wiley +1 more source
International ImmunopharmacologyCarbapenemase-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is a common pathogen that can cause severe pneumonia. The innate immune response, especially the response of macrophages, plays a crucial role in the host's defense against bacterial infections. Glycolysis is implicated in the modulation of immune functions in macrophages.
Qingyue, Zhang +13 more
openaire +2 more sources
The global genomic landscape of hypervirulent Klebsiella pneumoniae from 1932 to 2021
mLife, Volume 4, Issue 4, Page 378-396, August 2025.Abstract The global spread of hypervirulent Klebsiella pneumoniae (hvKp) poses a serious public health threat. In this study, we conducted genomic epidemiology analysis on 2097 global hvKp isolates, including our 900 isolates sequenced through the Illumina platform (177 of them fully sequenced through PacBio platform), representing the most ...
Xiaoyuan Jiang +12 more
wiley +1 more source
Investigation on Klebsiella pneumoniae in the field of extracellular vesicles
Interdisciplinary Medicine, Volume 3, Issue 4, July 2025.The role of extracellular vesicles in the pathogenicity and antibiotic resistance, as well as treatment and prevention of Klebsiella pneumoniae. Abstract Klebsiella pneumoniae (KP), recognized for its pronounced antibiotic resistance, is a prevalent agent of nosocomial infections such as hospital‐acquired pneumonia.
Junwei Wu +10 more
wiley +1 more source
Journal of Global Antimicrobial Resistance, 2020 Objective: We investigated the pathogenesis of a patient with severe acute pancreatitis by comprehensively analysing a rare carbapenem-resistant hypervirulent K1/ST1265 Klebsiella pneumoniae (CR-HvKP) strain. Methods: We conducted virulence and multidrug-
Cuidan Li +11 more
doaj +1 more source
Chemical Biology &Drug Design, Volume 105, Issue 5, May 2025.The synthetic peptides WK‐MAP1 and WG‐MAP2, bioinspired by papain, demonstrated optimized activity, particularly against multidrug‐resistant Klebsiella pneumoniae, with improved sequence interaction profiles, membrane affinity, and predicted antimicrobial and antibiofilm efficacy, supporting their potential as therapeutic peptide candidates.
Marcos Antônio Ferreira +8 more
wiley +1 more source