Results 71 to 80 of about 2,580 (182)

Emergence of Multidrug Resistant Hypervirulent ST23 Klebsiella pneumoniae: Multidrug Resistant Plasmid Acquisition Drives Evolution

Frontiers in Cellular and Infection Microbiology, 2020
BackgroundIn recent years, the emergence of multidrug resistant hypervirulent K. pneumoniae (MDR hvKp) isolates poses severe therapeutic challenge to global public health.
Chaitra Shankar, Jobin John Jacob, Karthick Vasudevan, Rohit Biswas, Abi Manesh, Dhiviya Prabaa Muthuirulandi Sethuvel, Santosh Varughese, Indranil Biswas, Balaji Veeraraghavan   +8 more
doaj   +1 more source

Gut Commensal Klebsiella pneumoniae Extracellular Vesicles Shape a Liver Microenvironment Conducive to Gut‐Liver Bacterial Translocation and Pro‐Tumorigenic Processes

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Bacterial extracellular vesicles (EVs) are emerging mediators of host–microbe communication; however, their role in human disease remains unclear. Here, we identify two bacterial small tRNAs (tsRNAs) enriched in gut commensal Klebsiella pneumoniae‐derived EVs (KpEVs) that are markedly elevated in the serum of patients with hepatocellular ...
Shogo Tsubaki, Sho Nashimoto, Rika Tanaka, Touya Toyomoto, Hiroyasu Tsutsuki, Ken Kato, Jun Nakayama, Kiminori Kimura, Kazuki Oshima, Yusuke Yamamoto, Takuji Okusaka, Minoru Esaki, Nobuhiro Kawai, Nobuyuki Ota, Yusuke Yoshioka, Takahiro Ochiya, Yoshimasa Saito, Tomohiro Sawa, Katsuto Hozumi, Juntaro Matsuzaki, Hitoshi Tsugawa   +20 more
wiley   +1 more source

DataSheet_1_Resistance of hypervirulent Klebsiella pneumoniae to cathepsin B-mediated pyroptosis in murine macrophages.docx

, 2023
IntroductionHypervirulent Klebsiella pneumoniae (hvKp) has emerged as a clinically significant global pathogen in the last decade. However, the host immune responses of the macrophages during hvKp infection are largely unknown.
Won-Ki Baek (8923805), Jong-Hwan Park (360574), Hui-Jung Jung (16465266), Miri Hyun (9750146), Ji Yeon Lee (2295001), Hyun ah Kim (10170452), Jin Kyung Kim (512515), Seong-Il Suh (16465269)   +7 more
core   +1 more source

Comparative Proteomic Profiling of Clinical Klebsiella pneumoniae Strains and the Corresponding Outer Membrane Vesicles

Journal of Extracellular Biology, Volume 5, Issue 4, April 2026.
ABSTRACT Klebsiella pneumoniae (K. pneumoniae) has become a global threat due to the convergence of carbapenem resistance and hypervirulence. Outer membrane vesicles (OMVs) play important roles in bacterial pathogenicity, yet their functional coordination with strains remains unclear.
Zongping Li, Jingyuan Xi, Xinmiao Jia, Yangzhige He, Guibin Wang, Shiyu Chen, Xiaobing Chu, Qian Zhang, Ying Zhu, Wei Yu, Peiyao Jia, Xiaoyu Liu, Qiwen Yang   +12 more
wiley   +1 more source

A Case Series of Hypermucoid Klebsiella pneumoniae Liver Abscess in Caucasian Americans Without Travel History: An Epidemiologic Shift?

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging cause of community‐acquired pyogenic liver abscess (PLA), classically described in East and Southeast Asia. We report two cases of hvKp‐associated PLA in Caucasian women of American origin with no history of international travel, animal exposure, or Asian food consumption. Both patients
Krishna Sai Kiran Sakalabaktula, Sameer Kumar Majety, Sri Ratna Divya Nanduri, Divya Durga, David Kreps, Devi Prasad Botu, Gopichand Muppana   +6 more
wiley   +1 more source

Lemierre's Syndrome Caused by Klebsiella pneumoniae: Case Report and Review of the Literature

Clinical Case Reports, Volume 14, Issue 2, February 2026.
Axial contrast‐enhanced chest CT demonstrating multiple peripheral cavitary nodules and consolidations, predominantly in the right lower lobe, consistent with septic pulmonary emboli (arrows). ABSTRACT Klebsiella pneumoniae is an uncommon but increasingly recognized cause of Lemierre's syndrome, a condition classically associated with Fusobacterium ...
Abril Aguilar Guerrero, Eduardo Porras Rosales   +1 more
wiley   +1 more source

Global Trends and Current Status of Research on Hypervirulent Klebsiella pneumoniae

International Journal of Clinical Practice, Volume 2026, Issue 1, 2026.
Background Hypervirulent Klebsiella pneumoniae (hvKP) has emerged as a critical public health concern due to its propensity to cause life‐threatening invasive infections, often leading to fatal outcomes. This study aims to systematically reveal the current research status of hvKP, outline key developmental trends in the field, and establish a ...
Yingbin Huang, Ting Liu, Bin Li, Fenfang Dong, Xueyong Li, Rongqi Lin, Yiying Chen, Bo Chen, Shengcen Zhang, Yu Cheng, Hongqiang Qiu, Zhichang Zhao, Marta Laranjo   +12 more
wiley   +1 more source

Comparative and Subtractive Genomics Analysis of Multidrug‐Resistant Klebsiella pneumoniae Strains for Novel Target Identification and Drug Repurposing Strategies

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
The rapid rise of multidrug‐resistant (MDR) Klebsiella pneumoniae has created a major global health challenge due to the limited availability of conserved therapeutic targets effective across diverse resistant strains. In this study, an integrative computational target‐discovery and drug‐repurposing framework was applied to six clinically relevant K ...
Manasi Bora, Prokriti Paul, Sanchaita Rajkhowa, Harshita Sonar, Borakha Bura Gohain, Magdi E. A. Zaki, Dhamodharan Prabhu, Shweta Negi   +7 more
wiley   +1 more source

Co‐Occurrence of Resistance to Aminoglycosides and Carbapenems in Klebsiella pneumoniae: A Critical Threat to Public Health

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Antimicrobial resistance (AMR) in Klebsiella pneumoniae, especially the co‐occurrence of resistance to aminoglycosides and carbapenems, represents a serious threat to global public health. This study reviews the prevalence of this combined resistance, analyzes the underlying mechanisms, and evaluates its impact on clinical practice and public health ...
Rafael Artur de Queiroz Cavalcanti de Sa, Tainara Fernandes Dantas, Sérgio Costa Júnior, Karolayne Oliveira da Silva, Maria Cecília Ferreira Galindo, Amanda Vieira de Barros, John Eversong Lucena de Vasconcelos, Radosław Kowalski, Grażyna Kowalska, Rafal Rowinski, Henrique Douglas Melo Coutinho, Maria Betânia Melo Oliveira, Divakar Sharma   +12 more
wiley   +1 more source

Genomic Evolution of the Increasing Prevalent Carbapenem‐Resistant Hypervirulent ST15 Klebsiella pneumoniae

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Purpose ST15 Klebsiella pneumoniae (Kp) is increasingly prevalent in China and worldwide. Currently, the mechanisms underlying the acquisition of hypervirulence‐associated genes in sequence Type 15 (ST15) Kp are still not well studied. The global prevalence of ST15 Kp is increasing, alongside notable increases in both resistance and virulence.
Shuaihua Fan, Pengcheng Du, Yunfei Tang, Huaiqing Qi, Chao Liu, Jun Guo, Mohamed Salah Abbassi   +6 more
wiley   +1 more source