Results 61 to 70 of about 2,580 (182)

The emergence of the hypervirulent Klebsiella pneumoniae (hvKp) strains among circulating clonal complex 147 (CC147) harbouring blaNDM/OXA-48 carbapenemases in a tertiary care center of Iran [PDF]

Annals of Clinical Microbiology and Antimicrobials, 2020
Abstract Background Klebsiella pneumoniae is a public health concern because of its ability to develop multidrug resistance and hypervirulent genotypes, of those capsular types K1 and K2 cause community and nosocomial life-threatening infections.
Omid Pajand, Narges Darabi, Maedeh Arab, Raheb Ghorbani, Zakaria Bameri, Ali Ebrahimi, Zoya Hojabri   +6 more
openaire   +3 more sources

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Interplay Between Virulence Genes, Antimicrobial Resistance Profiles, and Biofilm Formation in Klebsiella pneumoniae Causing Urinary Tract Infections in North Lebanon

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
– Figure design (single panel) Central icon: K. pneumoniae cell Left panel – Virulence genes (icons): Adhesion: fimH, mrkD → strong biofilm Capsule/regulation: magA, rmpA Siderophores: entB, iucA → iron uptake Right panel – Outcomes: Biofilm strength (weak → strong gradient) Antibiotic resistance (ESBL, MDR) Bottom split: Hospital‐acquired → strong ...
Mazen Zaylaa, Rayan Farha, Jana Taleb, Amal Saad, Omar El Gharbawy, Ricardo Sarraf, Ibtihal Kassam, Chadi Hamdach, Nisrine Bissar   +8 more
wiley   +1 more source

The first case of abdominal mycotic aneurysm caused by K1 hypervirulent Klebsiella pneumoniae in a healthy adult [PDF]

, 2021
Incidence of hypervirulent Klebsiella pneumoniae (hvKp) infection has been steadily increasing in the Asia-Pacific rim. The characteristic of hvKp infection is its ability to cause multiple site infections and unpredictable metastatic spread in the ...
Hyunjoo Oh, Young Ree Kim, Sang Taek Heo, Keun Hwa Lee, Jeong Rae Yoo, Misun Kim   +5 more
core   +2 more sources

Multiplex visual nucleic acid detection via isothermal cascaded transcription of fluorescent RNA aptamers

VIEW, Volume 7, Issue 3, June 2026.
(1) Existing multiplex nucleic acid detection struggles to combine high sensitivity, visual readout, and instrument‐free use, which is vital for rapid infection and antibiotic resistance diagnosis. (2) We developed MAGIC, integrating isothermal cascaded amplification and fluorescent RNA aptamer transcription, achieving 10 aM sensitivity, 100% accuracy ...
Yu Tang, Na Luo, Binbin Xie, Jie Luo, Yaling Yuan, Junjie Fan, Zhiyong Liu, Haiyan Gao, Ming Chen, Kai Chang   +9 more
wiley   +1 more source

The Galleria mellonella Infection Model Does Not Accurately Differentiate between Hypervirulent and Classical Klebsiella pneumoniae

mSphere, 2020
Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging pathogen of increasing concern due to its ability to cause serious organ and life-threatening infections in healthy individuals and its increasing acquisition of antimicrobial resistance ...
Thomas A. Russo, Ulrike MacDonald
doaj   +1 more source

Exploring the Antimicrobial Efficacy of Mesenchymal Stem Cell Secretome Against Klebsiella pneumoniae in Urinary Tract Infections

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Antimicrobial resistance (AMR) has become a global health crisis, with Klebsiella pneumoniae (K. pneumoniae) emerging as a major driver of AMR and a leading cause of urinary tract infections (UTIs). Mesenchymal stem cell (MSC)‐derived secretomes have gained attention for their antimicrobial properties.
Leen Ali, Elie Salem Sokhn, Charbel Khalil, Fatima A. Saleh   +3 more
wiley   +1 more source

Unraveling Hypervirulent Klebsiella pneumoniae (hvkp): leveraging the Maga gene as a biomarker for strong biofilm forming hvkp

Abstract Background This study aims to distinguish hypervirulent Klebsiella pneumoniae (hvKp) from its classical counterpart (cKp) by utilizing Potassium tellurite agar (PTA) and the String test, with a focus on biofilm formation. The magA gene is investigated as a potential biomarker for identifying robust biofilm-producing hvKp strains ...
Latha R, Aravind Sasi, Kavitha K, Thiyagarajan sanjeevi, Pramodhini S, Aboobacker P A   +5 more
openaire   +1 more source

Genomic Insights Into Carbapenem‐Resistant Klebsiella pneumoniae in Pediatric Bloodstream Infections in Zhejiang, China (2019–2024)

Journal of Clinical Laboratory Analysis, Volume 40, Issue 10, May 2026.
The primary mechanism of carbapenem resistance identified in pediatric CRKP‐BSI strains was the production of Class B metalloenzymes. We report, for the first time, an outbreak of bloodstream infections in a neonatal ward caused by the dissemination of NDM‐1‐producing ST25 K. pneumoniae.
Mingming Zhou, Xiucai Zhang, Zhenjie Chen, Chao Fang, Shixing Liu, Jintao Xia, Yining Zhao, Chenmei Zhang, Hongqiang Shen   +8 more
wiley   +1 more source

Emergence and Genomic Characterization of a Hypervirulent Klebsiella pneumoniae Isolate From a New Clone in Brazil

Microbiology and Immunology, Volume 70, Issue 5, Page 261-267, May 2026.
ABSTRACT Hypervirulent Klebsiella pneumoniae (hvKp) has emerged globally as a major public health concern, often associated with severe community‐acquired and healthcare‐associated human infections. Despite alerts from PAHO/WHO on convergent hvKp strains with multidrug resistance in Latin America, comprehensive data from Brazil, the region's largest ...
Carlos Henrique Camargo, Ana Beatriz Nascimento Costa, Amanda Yaeko Yamada, Daniel de Sena Miranda, Pedro Smith Pereira Ferraro, Andreia Rodrigues de Souza, Amanda Maria de Jesus Bertani, Karoline Rodrigues Campos, Marlon Benedito Nascimento Santos, Rafaela Mastrangelo Rissetti, Carolina Lechinski de Paula, Patrik Júnior de Lima Paz, Maria Solange Duarte Soares, Christiane Salvador, Giovanna de Pinho Pieri, Jorge Siguemassa Higa, Daniela dos Santos Souza, Márcio Garcia Ribeiro, Claudio Tavares Sacchi, Monique Ribeiro Tiba‐Casas, Geraldine Madalosso, Denise Brandao de Assis   +21 more
wiley   +1 more source