Results 61 to 70 of about 2,369 (178)

The Galleria mellonella Infection Model Does Not Accurately Differentiate between Hypervirulent and Classical Klebsiella pneumoniae

open access: yesmSphere, 2020
Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging pathogen of increasing concern due to its ability to cause serious organ and life-threatening infections in healthy individuals and its increasing acquisition of antimicrobial resistance ...
Thomas A. Russo, Ulrike MacDonald
doaj   +1 more source

Multiplex visual nucleic acid detection via isothermal cascaded transcription of fluorescent RNA aptamers

open access: yesVIEW, Volume 7, Issue 3, June 2026.
(1) Existing multiplex nucleic acid detection struggles to combine high sensitivity, visual readout, and instrument‐free use, which is vital for rapid infection and antibiotic resistance diagnosis. (2) We developed MAGIC, integrating isothermal cascaded amplification and fluorescent RNA aptamer transcription, achieving 10 aM sensitivity, 100% accuracy ...
Yu Tang   +9 more
wiley   +1 more source

Mechanism of virulence polymorphism in CR-hvKP strains from the same source

open access: yesMicrobiology Spectrum
ABSTRACT Carbapenem-resistant Klebsiella pneumoniae (CRKP) has become a major public health issue worldwide due to its high case fatality rate and transmissible nature. The plasmid containing drug-resistant and virulence genes obtained by CRKP can evolve into carbapenem ...
Jianhua Fang   +6 more
openaire   +3 more sources

Exploring the Antimicrobial Efficacy of Mesenchymal Stem Cell Secretome Against Klebsiella pneumoniae in Urinary Tract Infections

open access: yesClinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Antimicrobial resistance (AMR) has become a global health crisis, with Klebsiella pneumoniae (K. pneumoniae) emerging as a major driver of AMR and a leading cause of urinary tract infections (UTIs). Mesenchymal stem cell (MSC)‐derived secretomes have gained attention for their antimicrobial properties.
Leen Ali   +3 more
wiley   +1 more source

Genomic Insights Into Carbapenem‐Resistant Klebsiella pneumoniae in Pediatric Bloodstream Infections in Zhejiang, China (2019–2024)

open access: yesJournal of Clinical Laboratory Analysis, Volume 40, Issue 10, May 2026.
The primary mechanism of carbapenem resistance identified in pediatric CRKP‐BSI strains was the production of Class B metalloenzymes. We report, for the first time, an outbreak of bloodstream infections in a neonatal ward caused by the dissemination of NDM‐1‐producing ST25 K. pneumoniae.
Mingming Zhou   +8 more
wiley   +1 more source

Emergence of Multidrug Resistant Hypervirulent ST23 Klebsiella pneumoniae: Multidrug Resistant Plasmid Acquisition Drives Evolution

open access: yesFrontiers in Cellular and Infection Microbiology, 2020
BackgroundIn recent years, the emergence of multidrug resistant hypervirulent K. pneumoniae (MDR hvKp) isolates poses severe therapeutic challenge to global public health.
Chaitra Shankar   +8 more
doaj   +1 more source

DataSheet_1_Resistance of hypervirulent Klebsiella pneumoniae to cathepsin B-mediated pyroptosis in murine macrophages.docx

open access: yes, 2023
IntroductionHypervirulent Klebsiella pneumoniae (hvKp) has emerged as a clinically significant global pathogen in the last decade. However, the host immune responses of the macrophages during hvKp infection are largely unknown.
Won-Ki Baek (8923805)   +7 more
core   +1 more source

Gut Commensal Klebsiella pneumoniae Extracellular Vesicles Shape a Liver Microenvironment Conducive to Gut‐Liver Bacterial Translocation and Pro‐Tumorigenic Processes

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Bacterial extracellular vesicles (EVs) are emerging mediators of host–microbe communication; however, their role in human disease remains unclear. Here, we identify two bacterial small tRNAs (tsRNAs) enriched in gut commensal Klebsiella pneumoniae‐derived EVs (KpEVs) that are markedly elevated in the serum of patients with hepatocellular ...
Shogo Tsubaki   +20 more
wiley   +1 more source

Lemierre's Syndrome Caused by Klebsiella pneumoniae: Case Report and Review of the Literature

open access: yesClinical Case Reports, Volume 14, Issue 2, February 2026.
Axial contrast‐enhanced chest CT demonstrating multiple peripheral cavitary nodules and consolidations, predominantly in the right lower lobe, consistent with septic pulmonary emboli (arrows). ABSTRACT Klebsiella pneumoniae is an uncommon but increasingly recognized cause of Lemierre's syndrome, a condition classically associated with Fusobacterium ...
Abril Aguilar Guerrero   +1 more
wiley   +1 more source

Co‐Occurrence of Resistance to Aminoglycosides and Carbapenems in Klebsiella pneumoniae: A Critical Threat to Public Health

open access: yesInternational Journal of Microbiology, Volume 2026, Issue 1, 2026.
Antimicrobial resistance (AMR) in Klebsiella pneumoniae, especially the co‐occurrence of resistance to aminoglycosides and carbapenems, represents a serious threat to global public health. This study reviews the prevalence of this combined resistance, analyzes the underlying mechanisms, and evaluates its impact on clinical practice and public health ...
Rafael Artur de Queiroz Cavalcanti de Sa   +12 more
wiley   +1 more source

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