Results 51 to 60 of about 4,353 (174)

Hypermucoviscous Klebsiella pneumoniae: A Hypervirulent Strain Masquerading as Metastasis

Cureus, 2023
Hypermucoviscous Klebsiella pneumoniae (HvKP) is a hypervirulent strain of Klebsiella that causes metastatic spread and life-threatening infection. While it is more common among people of Asian descent, it has been increasingly reported globally among people of other ethnicities as well.
Ombada, Mulham, Perwez, Talha, Campitelli, Marco, Zeineddine, Nabil   +3 more
openaire   +2 more sources

Convergence of carbapenem resistance and hypervirulence leads to high mortality in patients with postoperative Klebsiella pneumoniae meningitis

Journal of Global Antimicrobial Resistance, 2021
: Objectives: The aims of this study were to investigate the characteristics of Klebsiella pneumoniae meningitis and the impact of convergence of carbapenem resistance and hypervirulence on patient mortality.Methods: Antimicrobial resistance and ...
Yuming Li, Dakang Hu, Xiaobo Ma, Dan Li, Dongxing Tian, Ye Gong, Xiaofei Jiang   +6 more
doaj   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Multiplex visual nucleic acid detection via isothermal cascaded transcription of fluorescent RNA aptamers

VIEW, Volume 7, Issue 3, June 2026.
(1) Existing multiplex nucleic acid detection struggles to combine high sensitivity, visual readout, and instrument‐free use, which is vital for rapid infection and antibiotic resistance diagnosis. (2) We developed MAGIC, integrating isothermal cascaded amplification and fluorescent RNA aptamer transcription, achieving 10 aM sensitivity, 100% accuracy ...
Yu Tang, Na Luo, Binbin Xie, Jie Luo, Yaling Yuan, Junjie Fan, Zhiyong Liu, Haiyan Gao, Ming Chen, Kai Chang   +9 more
wiley   +1 more source

Klebsiella pneumoniae K2 producer of pyogenic liver abscess associated with biliary communication

Journal of Infection in Developing Countries, 2022
Introduction: Hypervirulent strains of Klebsiella pneumoniae have gained clinical and epidemiological interest because of their capacity to cause severe and life-threatening infections.
Daniel Aguilar-Zapata, Josefina Duran-Bedolla, Luis Esaú López-Jácome, Humberto Barrios-Camacho, Ulises Garza-Ramos, Rafael Valdez-Vázquez   +5 more
doaj   +1 more source

Exploring the Antimicrobial Efficacy of Mesenchymal Stem Cell Secretome Against Klebsiella pneumoniae in Urinary Tract Infections

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Antimicrobial resistance (AMR) has become a global health crisis, with Klebsiella pneumoniae (K. pneumoniae) emerging as a major driver of AMR and a leading cause of urinary tract infections (UTIs). Mesenchymal stem cell (MSC)‐derived secretomes have gained attention for their antimicrobial properties.
Leen Ali, Elie Salem Sokhn, Charbel Khalil, Fatima A. Saleh   +3 more
wiley   +1 more source

Genomic Insights Into Carbapenem‐Resistant Klebsiella pneumoniae in Pediatric Bloodstream Infections in Zhejiang, China (2019–2024)

Journal of Clinical Laboratory Analysis, Volume 40, Issue 10, May 2026.
The primary mechanism of carbapenem resistance identified in pediatric CRKP‐BSI strains was the production of Class B metalloenzymes. We report, for the first time, an outbreak of bloodstream infections in a neonatal ward caused by the dissemination of NDM‐1‐producing ST25 K. pneumoniae.
Mingming Zhou, Xiucai Zhang, Zhenjie Chen, Chao Fang, Shixing Liu, Jintao Xia, Yining Zhao, Chenmei Zhang, Hongqiang Shen   +8 more
wiley   +1 more source

Bacteriophages with depolymerase activity in the control of antibiotic resistant Klebsiella pneumoniae biofilms

Scientific Reports, 2023
Klebsiella pneumoniae is associated with a variety of infections, such as pneumonia, urogenital infection, liver abscess, and bloodstream infection. It is especially dangerous for patients in medical facilities, where it can cause ventilator-associated ...
Fedor Zurabov, Egor Glazunov, Tatiana Kochetova, Viktoria Uskevich, Valentina Popova   +4 more
doaj   +1 more source

Bronchoscopic Direct Drainage of a Treatment‐Resistant Lung Abscess via Endoscopic Balloon Dilation in a High‐Risk Patient

Respirology Case Reports, Volume 14, Issue 5, May 2026.
Bronchoscopic direct drainage after balloon dilation can be a viable treatment option for patients with a severe, treatment‐resistant lung abscess who have comorbidities and are not eligible for percutaneous transthoracic drainage or surgery. ABSTRACT A 49‐year‐old man presented with a cough, hemoptysis and fever.
Nana Yazawa, Yusuke Nakamura, Akihiro Takemasa, Yuri Nomura, Minori Hanato, Noriaki Nishimura, Nobuaki Yoshida, Azusa Tsukada, Nobuhiko Tsukada, Hiroaki Okutomi, Yasuo Shimizu, Seiji Niho   +11 more
wiley   +1 more source

Gut Commensal Klebsiella pneumoniae Extracellular Vesicles Shape a Liver Microenvironment Conducive to Gut‐Liver Bacterial Translocation and Pro‐Tumorigenic Processes

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Bacterial extracellular vesicles (EVs) are emerging mediators of host–microbe communication; however, their role in human disease remains unclear. Here, we identify two bacterial small tRNAs (tsRNAs) enriched in gut commensal Klebsiella pneumoniae‐derived EVs (KpEVs) that are markedly elevated in the serum of patients with hepatocellular ...
Shogo Tsubaki, Sho Nashimoto, Rika Tanaka, Touya Toyomoto, Hiroyasu Tsutsuki, Ken Kato, Jun Nakayama, Kiminori Kimura, Kazuki Oshima, Yusuke Yamamoto, Takuji Okusaka, Minoru Esaki, Nobuhiro Kawai, Nobuyuki Ota, Yusuke Yoshioka, Takahiro Ochiya, Yoshimasa Saito, Tomohiro Sawa, Katsuto Hozumi, Juntaro Matsuzaki, Hitoshi Tsugawa   +20 more
wiley   +1 more source