Results 41 to 50 of about 4,353 (174)

Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae

Frontiers in Microbiology, 2023
Hypervirulence and carbapenem-resistant have emerged as two distinct evolutionary pathotypes of Klebsiella pneumoniae, with both reaching their epidemic success and posing a great threat to public health. However, as the boundaries separating these two pathotypes fade, we assist a worrisome convergence in certain high-risk clones, causing hospital ...
Gabriel Mendes, Maria Leonor Santos, João F. Ramalho, Aida Duarte, Aida Duarte, Cátia Caneiras, Cátia Caneiras, Cátia Caneiras   +7 more
openaire   +4 more sources

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Genotypic And Phenotypic Surveillance Of Multidrug Resistance Of Hypermucoid K. Pneumoniae Among Clinical Isolates In AL Najaf City /Iraq

Magazin of Al-Kufa University for Biology
Hypervirulent Klebsiella pneumoniae strains  are the major cause of liver abscesses ,diabetes foot ulcers  and other  infections throughout Iraq, and these strains are usually antibiotics susceptible. Recently, hypervirulent K.
Ali Hussain Hmood, Mahdi H.M. Alammar
doaj   +1 more source

Extensively drug-resistant Klebsiella pneumoniae pneumonia: A case report

Journal of Acute Disease, 2020
Rationale: Extensively drug resistant Klebsiella pneumoniae is defined as resistant to least one antimicrobial agent in all but two or lesser antimicrobial categories.
Saurabh Karmakar, Somnath Bhattacharya, Shilpi Karmakar, Deependra Kumar Rai   +3 more
doaj   +1 more source

Whole Genome Characterization of Klebsiella Strains in European Hedgehogs and Human Nosocomial Settings Identified Shared Sequence Types, Antimicrobial Resistance Genes and Plasmids

Zoonoses and Public Health, EarlyView.
ABSTRACT Introduction Klebsiella pneumoniae is a pathogen associated with healthcare‐acquired infections and antimicrobial resistance (AMR) to beta‐lactams and carbapenems. Although wild animals are not typically exposed to antibiotics, they can harbour resistant strains. The European hedgehog (Erinaceus europaeus) is increasingly found in urban areas,
Biel Garcias, Chiara Seminati, Carolin M. Kobras, Samuel K. Sheppard, Rafael A. Molina‐López, Laila Darwich   +5 more
wiley   +1 more source

Metastatic infection of hypervirulent Klebsiella pneumoniae

IDCases
Hypervirulent Klebsiella pneumoniae(hvKp) has a unique ability to cause organ or life-threatening tissue invasive infection in multiple sites. This case highlights that classical hvKp resulted in multiple abscesses in every body site, especially in the necrotizing fasciitis and osteomyelitis.
Biying Zhang, Chao Liu, Yunfei Tang, Thomas A. Russo, Ming Lu   +4 more
openaire   +3 more sources

Hypervirulent Klebsiella pneumoniae – clinical and molecular perspectives [PDF]

Journal of Internal Medicine, 2019
AbstractHypervirulent Klebsiella pneumoniae (hvKp) has emerged as a concerning global pathogen. hvKp is more virulent than classical K. pneumoniae (cKp) and capable of causing community‐acquired infections, often in healthy individuals. hvKp is carried in the gastrointestinal tract, which contributes to its spread in the community and healthcare ...
J. E. Choby, J. Howard‐Anderson, D. S. Weiss   +2 more
openaire   +2 more sources

Molecular Epidemiology of Antimicrobial Resistance, Virulence and Capsular Serotypes of Carbapenemase-Carrying Klebsiella pneumoniae in China

Antibiotics, 2022
This study analyzed genomic data of 4643 strains of carbapenemase-carrying Klebsiella pneumoniae (KPN) in China by using the Kleborate software package.
Lina Zhao, Xinxin Xia, Ting Yuan, Junying Zhu, Zhen Shen, Min Li   +5 more
doaj   +1 more source

Interplay Between Virulence Genes, Antimicrobial Resistance Profiles, and Biofilm Formation in Klebsiella pneumoniae Causing Urinary Tract Infections in North Lebanon

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
– Figure design (single panel) Central icon: K. pneumoniae cell Left panel – Virulence genes (icons): Adhesion: fimH, mrkD → strong biofilm Capsule/regulation: magA, rmpA Siderophores: entB, iucA → iron uptake Right panel – Outcomes: Biofilm strength (weak → strong gradient) Antibiotic resistance (ESBL, MDR) Bottom split: Hospital‐acquired → strong ...
Mazen Zaylaa, Rayan Farha, Jana Taleb, Amal Saad, Omar El Gharbawy, Ricardo Sarraf, Ibtihal Kassam, Chadi Hamdach, Nisrine Bissar   +8 more
wiley   +1 more source

Hypervirulent Klebsiella pneumoniae in Cryptogenic Liver Abscesses, Paris, France

Emerging Infectious Diseases, 2018
Liver abscesses containing hypervirulent Klebsiella pneumoniae have emerged during the past 2 decades, originally in Southeast Asia and then worldwide. We hypothesized that hypervirulent K. pneumoniae might also be emerging in France. In a retrospective,
Benjamin Rossi, Maria Ludovica Gasperini, Véronique Leflon-Guibout, Alice Gioanni, Victoire de Lastours, Geoffrey Rossi, Safi Dokmak, Maxime Ronot, Olivier Roux, Marie-Hélène Nicolas-Chanoine, Bruno Fantin, Agnès Lefort   +11 more
doaj   +1 more source