Results 91 to 100 of about 13,103 (221)

Sleep Disorders and Genes [PDF]

, 2019
Versão preprintThe sleep-wake cycle is a neurobiological phenomenon that shows intervals of activity alternating with restfulness that appears with a periodicity approximating the 24h day-night cycle.
Amici, Amin, Ban, Barbagallo, Basheer, Borbely, Brando, Brower, Byrne, Cade, Cade, Carskadon, Chaki, Chang, Chase, Chatterjee, Chen, Cohen, Cohen, Dall’Ara, de Lima, Dement, Dijk, Dong, Evans, Franco-Tormo, Fuh, Gan-Or, Gillombardo, Gottesmann, Gottesmann, Guilleminault, Han, Hennessy, Hirotsu, Hobson, Hobson, Hu, Huang, Huang, Jinek, Johansson, Keenan, Khan, Li, Lin, Lind, Luo, Lusk, Mahowald, Mendlewicz, Mistlberger, Miyagawa, Monti, Murillo-Rodríguez, Naiman, Nir, Nishino, Nordgren, Ollila, Pace-Schott, Palagini, Panda, Pandi-Perumal, Parish, Parmeggiani, Parsons, Patel, Peirano, Petit, Posner, Potter, Rechtschaffen, Riddle, Rizzo, Roffwarg, Scammell, Scherer, Serretti, Serretti, Shalem, Siclari, Siegel, Spada, Subramani, Szentkirályi, Tafti, Torterolo, Torterolo, Torterolo, Torterolo, Torterolo, Toth, Toyoda, Truong, Turek, Utge, van Maanen, Videnovic, Von Economo, Wu, Yong   +101 more
core   +1 more source

Regulation of autophagy‐mediated pathways by diet, physical activity, and sleep in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) is a progressive, age‐related, neurodegenerative disorder marked by cognitive decline, memory loss, and accumulation of amyloid beta (Aβ) plaques and tau tangles. A key feature of AD is impaired protein homeostasis, often driven by autophagy dysfunction.
Ajish Ariyath, Zoe Mputhia, Christopher Dougherty, Bushra Kaleelur Rahuman, W. M. A. D. Binosha Fernando, Belinda Brown, Samantha L. Gardener, Stephanie R. Rainey‐Smith, Ralph Martins, Prashant Bharadwaj   +9 more
wiley   +1 more source

The role of orexins/hypocretins in alcohol use and abuse: an appetitive-reward relationship

Frontiers in Behavioral Neuroscience, 2012
Orexins (hypocretins) are neuropeptides synthesized in neurons located in the lateral, perifornical and dorsomedial hypothalamus. These neurons innervate many regions in the brain and modulate multiple other neurotransmitter systems. As a result of these
Andrezza Kyunmi Kim, Andrezza Kyunmi Kim, Robyn M Brown, Andrew J. eLawrence   +3 more
doaj   +1 more source

Sleep-wake disturbances 6 months after traumatic brain injury: a prospective study [PDF]

, 2017
Sleep-wake disturbances (SWD) are common after traumatic brain injury (TBI). In acute TBI, we recently found decreased CSF levels of hypocretin-1, a wake-promoting neurotransmitter.
Bassetti, Claudio L., Baumann, Christian R., Ludwig, Silke, Stocker, Reto, Werth, Esther   +4 more
core  

Association of Sleep Duration With Intracranial Atherosclerosis and Cerebral Small Vessel Disease: A Mediation by Metabolic Factors

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Data of community dweller adults were derived from a survey study (3038 participants). We found that sleep duration is associated with intracranial atherosclerosis and CSVD, and the association of long sleep duration with intracranial atherosclerosis and CSVD was partially mediated by blood pressure and fasting plasma glucose.
Hongbin Chen, Anqi Zhang, Weiqi Chen, Xueli Cai, Mengyuan Zhou, Shan Li, Jing Jing, Tiemin Wei, Yongjun Wang, Yuesong Pan, Yilong Wang   +10 more
wiley   +1 more source

Daily Fluctuation of Orexin Neuron Activity and Wiring: The Challenge of “Chronoconnectivity”

Frontiers in Pharmacology, 2018
In the heterogeneous hub represented by the lateral hypothalamus, neurons containing the orexin/hypocretin peptides play a key role in vigilance state transitions and wakefulness stability, energy homeostasis, and other functions relevant for motivated ...
Idris A. Azeez, Federico Del Gallo, Luigia Cristino, Marina Bentivoglio, Marina Bentivoglio   +4 more
doaj   +1 more source

Narcolepsy: autoimmunity, effector T cell activation due to infection, or T cell independent, major histocompatibility complex class II induced neuronal loss? [PDF]

, 2017
Human narcolepsy with cataplexy is a neurological disorder, which develops due to a deficiency in hypocretin producing neurons in the hypothalamus. There is a strong association with human leucocyte antigens HLA-DR2 and HLA-DQB1*0602.
Bassetti, Claudio L., Birchler, Thomas, Fontana, Adriano, Gast, Heidemarie, Recher, Mike, Reith, Walter   +5 more
core  

Orexin receptor agonist Yan 7874 is a weak agonist of orexin/hypocretin receptors and shows orexin receptor-independent cytotoxicity [PDF]

, 2017
Two promising lead structures of small molecular orexin receptor agonist have been reported, but without detailed analyses of the pharmacological properties.
af Gennas, Gustav Boije, Kukkonen, Jyrki P., Lindholm, Dan, Rinne, Maiju K., Turku, Ainoleena, Xhaard, Henri   +5 more
core   +2 more sources

Orexin/Hypocretin Signaling

, 2016
Orexin/hypocretin peptide (orexin-A and orexin-B) signaling is believed to take place via the two G-protein-coupled receptors (GPCRs), named OX1 and OX2 orexin receptors, as described in the previous chapters. Signaling of orexin peptides has been investigated in diverse endogenously orexin receptor-expressing cells - mainly neurons but also other ...
openaire   +2 more sources

Temporal Course of Cerebral Autoregulation in Patients With Narcolepsy Type 1: Two Case Reports

Frontiers in Neurology, 2019
Cerebral autoregulation is the mechanism by which constant cerebral blood flow is maintained despite changes in arterial blood pressure. In the two presented cases, cerebral autoregulation was impaired in patients with narcolepsy type 1, and both ...
Zhen-Ni Guo, Xin Sun, Yingkai Zhao, Xiuli Yan, Ran Zhang, Zan Wang, Yi Yang, Yi Yang   +7 more
doaj   +1 more source