Results 101 to 110 of about 13,103 (221)
Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish [PDF]
, 2015 Pharmacological studies in mammals suggest that norepinephrine (NE) plays an important role in promoting arousal. However, the role of endogenous NE is unclear, with contradicting reports concerning the sleep phenotypes of mice lacking NE due to mutation
Oikonomou, Grigorios +2 more
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Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through orexin-2 receptors. [PDF]
, 2014 Diurnal release of the orexin neuropeptides orexin-A (Ox-A, hypocretin-1) and orexin-B (Ox-B, hypocretin-2) stabilises arousal, regulates energy homeostasis and contributes to cognition and learning.
Longordo, F. +4 more
core +1 more source
Hypocretin as a Hub for Arousal and Motivation
Frontiers in Neurology, 2018 The lateral hypothalamus is comprised of a heterogeneous mix of neurons that serve to integrate and regulate sleep, feeding, stress, energy balance, reward, and motivated behavior.
Susan M. Tyree +2 more
doaj +1 more source
Regulation of zebrafish sleep and arousal states: current and prospective approaches
Frontiers in Neural Circuits, 2013 Every day, we shift among various states of sleep and arousal to meet the many demands of our bodies and environment. A central puzzle in neurobiology is how the brain controls these behavioral states, which are essential to an animal’s well-being and ...
Cindy N Chiu, David A Prober
doaj +1 more source
CSF prostaglandin D synthase is reduced in excessive daytime sleepiness [PDF]
, 2018 Lipocalin-type prostaglandin D synthase (L-PGDS) is a brain enzyme, which produces prostaglandin D2, a substance with endogenous somnogenic effects. Using a standardized protocol for immunonephelometric determination of cerebrospinal fluid (CSF) L-PGDS ...
Bassetti, Claudio +2 more
core
Sites of action of sleep and wake drugs: insights from model organisms [PDF]
, 2013 Small molecules have been used since antiquity to regulate our sleep. Despite the explosion of diverse drugs to treat problems of too much or too little sleep, the detailed mechanisms of action and especially the neuronal targets by which these compounds
Rihel, J, Schier, AF
core +1 more source
Neurobiology of Sleep and Circadian Rhythms, 2017 Disorders of sleep and wakefulness occur in the majority of individuals who have experienced traumatic brain injury (TBI), with increased sleep need and excessive daytime sleepiness often reported.
Hannah E. Thomasy +4 more
doaj +1 more source
Hypocretin underlies the evolution of sleep loss in the Mexican cavefish [PDF]
, 2018 The duration of sleep varies dramatically between species, yet little is known about the genetic basis or evolutionary factors driving this variation in behavior. The Mexican cavefish, Astyanax mexicanus, exists as surface populations that inhabit rivers,
Duboue, Erik R. +5 more
core +1 more source
Monitoring neural activity with bioluminescence during natural behavior [PDF]
, 2010 Existing techniques for monitoring neural activity in awake, freely behaving vertebrates are invasive and difficult to target to genetically identified neurons.
AD Douglass +54 more
core +2 more sources
Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far
Frontiers in Neuroscience, 2013 Emerging findings suggest the existence of a cross-talk between hypocretinergic and endocannabinoid systems. Although few studies have examined this relationship, the apparent overlap observed in the neuroanatomical distribution of both systems as well ...
África eFlores +2 more
doaj +1 more source