Results 11 to 20 of about 13,103 (221)

Increased immune complexes of hypocretin autoantibodies in narcolepsy. [PDF]

PLoS ONE, 2010
BACKGROUND: Hypocretin peptides participate in the regulation of sleep-wake cycle while deficiency in hypocretin signaling and loss of hypocretin neurons are causative for narcolepsy-cataplexy.
Aude Deloumeau, Sophie Bayard, Quentin Coquerel, Pierre Déchelotte, Christine Bole-Feysot, Bertrand Carlander, Valérie Cochen De Cock, Sergueï O Fetissov, Yves Dauvilliers   +8 more
doaj   +1 more source

Increased Hypocretin (Orexin) Plasma Level in Depression, Bipolar Disorder Patients

Frontiers in Psychiatry, 2021
As hypocretin can markedly affect neurophysiological and behavioural processes in mood disorders. However, few studies have measured changes in hypocretin levels in patients with mood disorders.
Haimei Li, Haimei Li, Haimei Li, Jing Lu, Jing Lu, Jing Lu, Shangda Li, Shangda Li, Shangda Li, Bochao Huang, Bochao Huang, Bochao Huang, Gongde Shi, Gongde Shi, Gongde Shi, Tingting Mou, Tingting Mou, Tingting Mou, Yi Xu, Yi Xu, Yi Xu, Yi Xu   +21 more
doaj   +1 more source

IGFBP3 colocalizes with and regulates hypocretin (orexin). [PDF]

PLoS ONE, 2009
The sleep disorder narcolepsy is caused by a vast reduction in neurons producing the hypocretin (orexin) neuropeptides. Based on the tight association with HLA, narcolepsy is believed to result from an autoimmune attack, but the cause of hypocretin cell ...
Makoto Honda, Krister S Eriksson, Shengwen Zhang, Susumu Tanaka, Ling Lin, Ahmad Salehi, Per Egil Hesla, Jan Maehlen, Stephanie E Gaus, Masashi Yanagisawa, Takeshi Sakurai, Shahrad Taheri, Kuniaki Tsuchiya, Yutaka Honda, Emmanuel Mignot   +14 more
doaj   +1 more source

Hypocretin role in posttraumatic stress disorder-like behaviors induced by a novel stress protocol in mice

Frontiers in Psychiatry, 2023
IntroductionPosttraumatic stress disorder (PTSD) is a psychiatric disorder developed in individuals who expose to traumatic events. These patients may experience symptoms, such as recurrent unwanted memory of the traumatic event, avoidance of reminders ...
Tung-Yen Lee, Pei-Lu Yi, Fang-Chia Chang, Fang-Chia Chang, Fang-Chia Chang, Fang-Chia Chang, Fang-Chia Chang   +6 more
doaj   +1 more source

Narcolepsy, autoimmunity, and influenza A H1N1 vaccination [PDF]

Encephalitis, 2021
Narcolepsy is a rare neurological disorder characterized by excessive daytime sleepiness (EDS) with or without cataplexy. A main pathophysiology of narcolepsy is hypocretin deficiency in the central nervous system resulting from a selective loss of ...
Jun-Sang Sunwoo
doaj   +1 more source

Orexinergic Input to Dopaminergic Neurons of the Human Ventral Tegmental Area [PDF]

, 2013
The mesolimbic reward pathway arising from dopaminergic (DA) neurons of the ventral tegmental area (VTA) has been strongly implicated in reward processing and drug abuse.
A Bisetti, AJ Lawrence, Alice Y. W. Chang, AR Di Sebastiano, B Boutrel, B Boutrel, B Wang, BA Baldo, Beáta Á. Borsay, C Baimel, C Peyron, CM Kotz, CS Molnar, Csilla S. Molnár, CV Dayas, D Georgescu, D Sulzer, E Hirsch, E Hrabovszky, E Hrabovszky, Erik Hrabovszky, G Aston-Jones, G Martin, GC Harris, GC Harris, J Fadel, J Xia, JA Hollander, JJ Balcita-Pedicino, K Mukai, L de Lecea, László Herczeg, M Barrot, M Narita, NM Vittoz, NM Vittoz, Péter Gergely, R Fronczek, R Sharf, R Sharf, RM Chemelli, S Deurveilher, S Srinivasan, SL Borgland, SV Mahler, T Bullmann, T Nakamura, T Sakurai, TM Korotkova, TM Korotkova, XY Lu, Y Date, Z Liposits, Zsolt Liposits   +53 more
core   +5 more sources

Narcolepsy Type 1: Should We Only Target Hypocretin Receptor 2?

Clinical and Translational Neuroscience, 2023
Nearly 25 years have passed since the ground-breaking discovery that hypocretin deficiency underlies human narcolepsy with cataplexy. Over time, it has become increasingly evident that hypocretin deficiency goes beyond the conventional core symptoms, or ...
Rolf Fronczek, Gert Jan Lammers
doaj   +1 more source

Progress of autonomic disturbances in narcolepsy type 1

Frontiers in Neurology, 2023
Narcolepsy type 1 is a kind of sleep disorder characterized by a specific loss of hypocretin neurons in the lateral hypothalamus and reduced levels of hypocretin-1 in the cerebrospinal fluid.
Ying Wang, Qingqing Sun, Qi Tang, Yanan Zhang, Mingyang Tang, Dong Wang, Zan Wang   +6 more
doaj   +1 more source

Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence. [PDF]

, 2012
Considerable evidence suggests that transmission at hypocretin-1 (orexin-1) receptors (Hcrt-R1) plays an important role in the reinstatement of extinguished cocaine-seeking behaviors in rodents.
Fowler, Christie D, Hollander, Jonathan A, Kenny, Paul J, Pham, Don   +3 more
core   +3 more sources

Hypocretin/orexin neurons encode social discrimination and exhibit a sex-dependent necessity for social interaction

Cell Reports, 2023
Summary: The hypothalamus plays a crucial role in the modulation of social behavior by encoding internal states. The hypothalamic hypocretin/orexin neurons, initially identified as regulators of sleep and appetite, are important for emotional and ...
Matthew Dawson, Dylan J. Terstege, Naila Jamani, Mio Tsutsui, Dmitrii Pavlov, Raluca Bugescu, Jonathan R. Epp, Gina M. Leinninger, Derya Sargin   +8 more
doaj   +1 more source