Genes and primary headaches: discovering new potential therapeutic targets [PDF]
, 2013 Genetic studies have clearly shown that primary headaches (migraine, tension-type headache and cluster headache) are multifactorial disorders characterized by a complex interaction between different genes and environmental factors.
De Martino, Paola +8 more
core +3 more sources
Molecular Metabolism, 2023 Objective: The present study tests the hypothesis that changes in the glucose sensitivity of lateral hypothalamus (LH) hypocretin/orexin glucose-inhibited (GI) neurons following weight loss leads to glutamate plasticity on ventral tegmental area (VTA ...
Suraj B. Teegala +8 more
doaj +1 more source
Comment on "Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2". [PDF]
, 2015 Did hypocretin receptor 2 autoantibodies cause narcolepsy with hypocretin deficiency in Pandemrix-vaccinated children, as suggested by Ahmed et al.? Using newly developed mouse models to report and inactivate hypocretin receptor expression, Vassalli et ...
Li, S., Tafti, M., Vassalli, A.
core +1 more source
Cluster headache: a quasi-rare disorder needing a reappraisal [PDF]
, 2015 Editoria
Martelletti, Paolo +1 more
core +1 more source
Effects of ambient temperature on sleep and cardiovascular regulation in mice: the role of hypocretin/orexin neurons. [PDF]
PLoS ONE, 2012 The central neural pathways underlying the physiological coordination between thermoregulation and the controls of the wake-sleep behavior and cardiovascular function remain insufficiently understood.
Viviana Lo Martire +4 more
doaj +1 more source
Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine [PDF]
, 2015 Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior.
Aguinaga, David +17 more
core +1 more source
Acute High Fat Diet Consumption Activates the Mesolimbic Circuit and Requires Orexin Signaling in a Mouse Model [PDF]
, 2014 Overconsumption of palatable energy-dense foods has negative health implications and it is associated with obesity andseveral eating disorders. Currently, little is known about the neuronal circuitries activated by the acute ingestion of arewarding ...
Patrone, Anabela +3 more
core +2 more sources
Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction. [PDF]
, 2013 The neurochemical changes underlying human emotions and social behaviour are largely unknown. Here we report on the changes in the levels of two hypothalamic neuropeptides, hypocretin-1 and melanin-concentrating hormone, measured in the human amygdala ...
Behnke, Eric J +9 more
core +1 more source
Hypocretin and brain β-amyloid peptide interactions in cognitive disorders and narcolepsy
Frontiers in Aging Neuroscience, 2014 Objective: To examine relationships between cerebrospinal fluid (CSF) Alzheimer’ disease (AD) biomarkers and hypocretin-1 levels in patients with cognitive abnormalities and hypocretin-deficient narcolepsy-cataplexy (NC), estimate diagnostic accuracy ...
Yves A Dauvilliers +4 more
doaj +1 more source
Reward-based behaviors and emotional processing in human with narcolepsy-cataplexy
Frontiers in Behavioral Neuroscience, 2013 ajor advances in the past decade have led a better understanding of the pathophysiology of narcolepsy with cataplexy caused by the early loss of hypothalamic hypocretin neurons.
Sophie eBayard, Yves A Dauvilliers
doaj +1 more source