Results 51 to 60 of about 13,103 (221)

Enhanced Visual Cortex Activation in People With Narcolepsy Type 1 During Active Sleep Resistance: An fMRI-EEG Study

Frontiers in Neuroscience, 2022
The brain activation patterns related to sleep resistance remain to be discovered in health and disease. The maintenance of wakefulness test (MWT) is an objective neuropsychological assessment often used to assess an individual’s ability to resist sleep.
Jari K. Gool, Jari K. Gool, Jari K. Gool, Jari K. Gool, Rolf Fronczek, Rolf Fronczek, Peter Bosma, Johan N. van der Meer, Ysbrand D. van der Werf, Ysbrand D. van der Werf, Gert Jan Lammers, Gert Jan Lammers   +11 more
doaj   +1 more source

Orexin in the chicken hypothalamus: immunocytochemical localisation and comparison of mRNA concentrations during the day and night, and after chronic food restriction [PDF]

, 2013
In mammals Orexin-A and -B are neuropeptides involved in the hypothalamic regulation of diverse physiological functions including food intake and the sleep-wake cycle.
de Girolamo, Paolo, Dunn, Ian C, Esposito, Vincenzo, Miranda, Bernadette, Sharp, Peter J, Wilson, Peter W   +5 more
core   +1 more source

Narcolepsy Following Yellow Fever Vaccination: A Case Report [PDF]

, 2016
Narcolepsy with cataplexy is a rare, but important differential diagnosis for daytime sleepiness and atonic paroxysms in an adolescent. A recent increase in incidence in the pediatric age group probably linked to the use of the Pandemrix influenza ...
Deb K. Pal, Michael Farquhar, Paul Gringras, Richard E. Rosch   +3 more
core   +3 more sources

The DNA/RNA autophagy protein SIDT2 as a novel neuropathological hallmark in Huntington disease

Brain Pathology, EarlyView.
SIDT2‐immunoreactive inclusions are observed in the striatum, cerebral cortex, and hypothalamus in HD cases with different Vonsattel grades, and the frequency of SIDT2‐immunoreactive inclusions is associated with longer CAG repeats in the huntingtin gene.
Sanaz Gabery, Sofia Bergh, Chrisovalantou Huridou, Rachel Y. Cheong, Barbara Baldo, Paul Günther Scheunemann, Marie‐Louisa Schoebel, Linda Holmquist Mengelbier, Elisabet Englund, Catriona McLean, Carsten Saft, Deniz Kirik, Maria Björkqvist, Glenda Halliday, Elisabeth Petrasch‐Parwez, Huu Phuc Nguyen, Jonasz Jeremiasz Weber, Åsa Petersén   +17 more
wiley   +1 more source

Hypocretin neuron-specific transcriptome profiling identifies the sleep modulator Kcnh4a [PDF]

, 2015
Sleep has been conserved throughout evolution; however, the molecular and neuronal mechanisms of sleep are largely unknown. The hypothalamic hypocretin/orexin (Hcrt) neurons regulate sleep/wake states, feeding, stress, and reward.
Alon, Shahar, Appelbaum, Lior, Dahary, Dvir, Diber, Alex, Elbaz, Idan, Gibbs-Bar, Liron, Lerer-Goldshtein, Tali, Yelin-Bekerman, Laura   +7 more
core   +2 more sources

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Orexin/hypocretin receptor signalling cascades [PDF]

British Journal of Pharmacology, 2013
Orexin (hypocretin) peptides and their two known G‐protein‐coupled receptors play essential roles in sleep–wake control and powerfully influence other systems regulating appetite/metabolism, stress and reward. Consequently, drugs that influence signalling by these receptors may provide novel therapeutic opportunities for treating sleep disorders ...
J P, Kukkonen, C S, Leonard
openaire   +2 more sources

Ageing‐related modification of sleep and breathing in orexin‐knockout narcoleptic mice

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Narcolepsy type‐1 (NT1) is a lifelong sleep disease, characterised by impairment of the orexinergic system, with a typical onset during adolescence and young adulthood. Since the wake–sleep cycle physiologically changes with ageing, this study aims to compare sleep patterns between orexin‐knockout (KO) and wild type (WT) control mice at ...
Stefano Bastianini, Sara Alvente, Chiara Berteotti, Viviana Lo Martire, Gabriele Matteoli, Elena Miglioranza, Alessandro Silvani, Giovanna Zoccoli   +7 more
wiley   +1 more source

Suspected acquired narcolepsy in 8 dogs

Journal of Veterinary Internal Medicine, 2021
Background Acquired narcolepsy has rarely been reported in veterinary medicine. Objective To describe the presentation, clinicopathological features, diagnostic imaging findings, and management of dogs with suspected‐acquired narcolepsy.
Koen M. Santifort, Edward J. Ives, Joe Fenn, Francesca Raimondi, Filipa Lourinho, Paul J. J. Mandigers, Niklas Bergknut   +6 more
doaj   +1 more source

iSPHYNCS: Unsupervised clustering in questionnaires and metadata reveals distinct subtypes in the narcolepsy borderland

Journal of Sleep Research, EarlyView.
Study overview and clustering results in the iSPHYNCS cohort. Participant demographics are summarized in a baseline table. Questionnaire data and metadata were processed through an unsupervised clustering pipeline. A Sankey plot illustrates individual assignment across clusters by diagnostic group.
Morand R, Fregolente L, van der Meer J, Wenz ES, Helmy A, Brigato L, Warncke JD, Zub K, Khatami R, Zhang Z, von Manitius S, Miano S, Acker J, Strub M, Kallweit U, Lammers GJ, Tzovara A, Bassetti CL, Mougiakakou S, Schmidt MH.   +19 more
europepmc   +2 more sources