Results 61 to 70 of about 13,103 (221)
, 2016 How the brain controls vigilance state transitions remains to be fully understood. The discovery of hypocretins, also known as orexins, and their link to narcolepsy has undoubtedly allowed us to advance our knowledge on key mechanisms controlling the boundaries and transitions between sleep and wakefulness.
Shi-Bin, Li +2 more
openaire +2 more sources
Orexin/Hypocretin: Wired for Wakefulness [PDF]
Current Biology, 2003 Orexin neurons play a crucial role in regulating wakefulness and energy metabolism, but until recently, little was known about the factors that influence the activity of these essential cells. Electrophysiological studies have now identified positive and negative feedback signals that allow the orexin neurons to help maintain wakefulness.
Mochizuki, Takatoshi +1 more
openaire +2 more sources
Journal of Sleep Research, EarlyView.How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads +8 more
wiley +1 more source
The Lateral Hypothalamus: An Uncharted Territory for Processing Peripheral Neurogenic Inflammation
Frontiers in Neuroscience, 2020 The roles of the hypothalamus and particularly the lateral hypothalamus (LH) in the regulation of inflammation and pain have been widely studied. The LH consists of a parasympathetic area that has connections with all the major parts of the brain.
Marc Fakhoury +5 more
doaj +1 more source
Journal of Sleep Research, EarlyView.ABSTRACT This pilot observational study evaluated whether frequent overnight sampling of ventricular cerebrospinal fluid could clarify how sleep, hypocretin and lactate relate to amyloid‐β42 dynamics in adults with hydrocephalus. Seven participants underwent hourly ventricular cerebrospinal fluid sampling from early evening to late morning during ...
Casper Schwartz Riedel +4 more
wiley +1 more source
Hypocretins or hyporexins? [PDF]
Nature Medicine, 1998 Lettera
NISOLI E +3 more
openaire +3 more sources
Nature Communications, 2019 T cells from narcolepsy patients were recently reported to recognize hypocretin, a wakefulness-promoting neurohormone, suggesting autoimmune origin of the disease. Here the authors show that hypocretin-specific T cells expand both in healthy controls and
Wei Jiang +17 more
doaj +1 more source
Untersuchung der Dopaminrezeptor- sowie Hypocretin-Gen-Polymorphismen bei Parkinsin-Patienten mit "Schlafattacken" [PDF]
, 2004 Das idiopathische Parkinson-Syndrom (IPS) ist eine neurodegenerative Erkrankung unklarer Ätiologie. Das IPS wird klinisch durch die Kardinalsymptome wie Ruhetremor, Rigor sowie Bradykinesie gekennzeichnet.
Oertel, Wolfgang Herrmann Professor +1 more
core +1 more source
Journal of Sleep Research, EarlyView.The “Not Better Explained” (NBE) criterion plays a key role in preventing diagnostic misclassification by structuring causal reasoning in sleep medicine. This systematic content analysis compares the use, wording, and excluded conditions of NBE criteria across the ICSD‐3‐TR and DSM‐5‐TR for ten major sleep disorders.
Jean‐Arthur Micoulaud‐Franchi +9 more
wiley +1 more source
Attention impairments and ADHD symptoms in adult narcoleptic patients with and without hypocretin deficiency. [PDF]
PLoS ONE, 2017 Attentional complaints are common in narcolepsy patients and can overlap with daytime sleepiness features. Few studies attempted to characterize attentional domains in narcolepsy leading to controversial results.
Marco Filardi +5 more
doaj +1 more source