Inherited IL-18BP deficiency in two Egyptian siblings with fulminant viral hepatitisIL-18BP deficiency and fulminant viral hepatitis [PDF]
Journal of Human ImmunityA previous report described an inherited deficiency of IL-18BP, a soluble antagonist of IL-18, in an Algerian patient who died of fulminant viral hepatitis (FVH) A. We report here an Egyptian family with two siblings who died from FVH following infection
Dalia Abd Elaziz +10 more
doaj +3 more sources
Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia [PDF]
Journal of Neuroinflammation, 2012 Background The pleiotropic pro-inflammatory cytokine Interleukin (IL)-18 has been proposed to play a role in schizophrenia, since elevated circulating levels of its protein and altered frequencies of genetic variants in its molecular system are reported ...
Palladino Ilaria +7 more
doaj +7 more sources
Subtype‐associated complexity and prognostic significance of the NLRP3 inflammasome landscape in pancreatic neoplasms [PDF]
The Journal of Pathology: Clinical ResearchIntraductal papillary mucinous neoplasm (IPMN) can progress into malignant pancreatic cancer, posing challenges in accurately assessing the risk of malignancy.
Kristóf Németh +7 more
doaj +3 more sources
Elevated Plasma IL-37, IL-18, and IL-18BP Concentrations in Patients with Acute Coronary Syndrome [PDF]
Mediators of Inflammation, 2014 Objective. More recently, evidence showed that the novel anti-inflammatory cytokine interleukin- (IL-) 37 was expressed in the foam-like cells of atherosclerotic coronary and carotid artery plaques, suggesting that IL-37 is involved in atherosclerosis ...
Qingwei Ji +11 more
doaj +5 more sources
Interleukin-18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis [PDF]
Hepatology, EarlyView., 2023 BACKGROUND AND AIMS: Nucleotide-binding oligomerization domain-like receptor-family pyrin domain-containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
et al.,, Knorr, Jana, Schilling, Joel D
core +3 more sources
Effect of IL-18BP on anxiety-like behavior in traumatic brain injury rats and its mechanism [PDF]
Xin yixue, 2023 Objective To evaluate the effect of IL-18 binding protein （IL-18BP） on anxiety-like behavior after traumatic brain injury （TBI） in rats and its related mechanism.
Li Yan, Qi Manman, Jiao Baojie, Li Chunlei, Wang Chunlei, Chang Yulin
doaj +2 more sources
IL-18/IL-37/IP-10 signalling complex as a potential biomarker for discriminating active and latent TB. [PDF]
PLoS ONE, 2019 BACKGROUND:Currently, there are serious limitations in the direct diagnosis of active tuberculosis (ATB). We evaluated the levels of the IL-18/IL-37/IP-10 signalling complex proteins in Mycobacterium tuberculosis (M.tb)-specific antigen-stimulated ...
Sebastian Wawrocki +5 more
doaj +2 more sources
Interleukin-18, Functional IL-18 Receptor and IL-18 Binding Protein Expression in Active and Latent Tuberculosis [PDF]
Pathogens, 2020 A thorough understanding of the processes modulating the innate and acquired immune response to Mycobacterium tuberculosis (M.tb) infection in the context of gene expression is still a scientific and diagnostic problem.
Sebastian Wawrocki +4 more
doaj +3 more sources
Protection from inflammatory organ damage in a murine model of hemophagocytic lymphohistiocytosis using treatment with IL-18 binding protein [PDF]
Frontiers in Immunology, 2012 Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition due to the association of an infectious agent with lymphocyte cytotoxicity defects, either of congenital genetic origin in children or presumably acquired in adults. In HLH patients,
Laura eChiossone +25 more
doaj +3 more sources
Circulating levels of IL-1 family cytokines and receptors in Alzheimer’s disease: new markers of disease progression? [PDF]
Journal of Neuroinflammation, 2018 Background Although the mechanisms underlying AD neurodegeneration are not fully understood, it is now recognised that inflammation could play a crucial role in the initiation and progression of AD neurodegeneration.
Paola Italiani +10 more
doaj +3 more sources