Results 21 to 30 of about 2,851 (168)

Identification of small molecule inhibitors of Interleukin-18 [PDF]

Scientific Reports, 2017
Interleukin-18 (IL-18) is a pleiotropic pro-inflammatory cytokine belonging to the IL-1 superfamily. IL-18 plays an important role in host innate and adaptive immune defense but its aberrant activities are also associated with inflammatory diseases such ...
Brian Krumm, Xiangzhi Meng, Yan Xiang, Junpeng Deng   +3 more
doaj   +3 more sources

Engineered IL-18 variants with half-life extension and improved stability for cancer immunotherapy [PDF]

Journal for ImmunoTherapy of Cancer
Background The pro-inflammatory cytokine, interleukin-18 (IL-18), plays an instrumental role in bolstering anti-tumor immunity. However, the therapeutic application of IL-18 has been limited due to its susceptibility to neutralization by IL-18 binding ...
Yue Zhao, Yan Qu, Marina Moskalenko, Dawei Sun, Travis W Bainbridge, Matthieu Masureel, Lifen Wang, Robert Herrera, Maciej T Paluch, Kazi Tasneem, Harpinder Saini, Manal Sadek, Mandy Kwong, Yoon Min Kim, Jay M Bhatt, Christine Tam, Pamela Pui Fung Chan, Ayse Meric Ovacik, Jonathan T Sockolosky, Nathaniel R West, Beyza Bulutoglu   +20 more
doaj   +2 more sources

Elevated serum levels of interleukin-18 discriminate Still's disease from other autoinflammatory conditions: results from the European ImmunAID cohort. [PDF]

RMD Open
OBJECTIVES: Systemic autoinflammatory diseases (SAIDs) represent a set of conditions with exaggerated innate immune responses. IL-1β and IL-18 are key cytokines involved in the pathogenesis of some SAID.
Girard-Guyonvarc'h C, Rodriguez E, Mueller YM, Caruso A, Katsikis PD, Gabay C, ImmunAID consortium.   +6 more
europepmc   +10 more sources

Targeting highly attenuated IL-18 to PD-1 for enhanced anti-tumor activity [PDF]

Frontiers in Immunology
Checkpoint inhibitors targeting the PD-1/PD-L1 axis have revolutionized cancer immunotherapy, yet response rates remain limited. To enhance efficacy, next-generation approaches target T cell-activating cytokines to PD-1 via antibodies.
Xueyuan Zhou, Felix Klaus Geyer, Jeffrey Takimoto, Harald Kolmar, Harald Kolmar, Brian Rabinovich   +5 more
doaj   +2 more sources

No IL-18BP? Avoid HAV. [PDF]

J Exp Med, 2019
Fulminant viral hepatitis occurs in a very small number of infected individuals. Until now, the basis for this phenotype has remained unknown. In this issue of JEM, Belkaya et al. (https://doi.org/10.1084/jem.20190669) identify a deletion in the IL18BP gene in a severely affected child that results in excessive natural killer cell activation and ...
Diamond MS.
europepmc   +4 more sources

Failure of interferon gamma to induce the anti-inflammatory interleukin 18 binding protein in familial hemophagocytosis. [PDF]

PLoS ONE, 2010
BACKGROUND: Familial hemophagocytosis (FHL) is a rare disease associated with defects in proteins involved in CD8+ T-cell cytotoxicity. Hyperactivation of immune cells results in a perilous, Th1-driven cytokine storm. We set out to explore the regulation
Claudia A Nold-Petry, Thomas Lehrnbecher, Andrea Jarisch, Dirk Schwabe, Josef M Pfeilschifter, Heiko Muhl, Marcel F Nold, Marcel F Nold   +7 more
doaj   +5 more sources

IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy. [PDF]

Nature, 2020
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer, but they have only modest efficacy and limited tolerability1,2. In an effort to identify alternative cytokine pathways for immunotherapy, we found that components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating ...
Zhou T, Damsky W, Weizman OE, McGeary MK, Hartmann KP, Rosen CE, Fischer S, Jackson R, Flavell RA, Wang J, Sanmamed MF, Bosenberg MW, Ring AM.   +12 more
europepmc   +4 more sources

Inherited IL-18BP deficiency in human fulminant viral hepatitis. [PDF]

J Exp Med, 2019
Fulminant viral hepatitis (FVH) is a devastating and unexplained condition that strikes otherwise healthy individuals during primary infection with common liver-tropic viruses. We report a child who died of FVH upon infection with hepatitis A virus (HAV) at age 11 yr and who was homozygous for a private 40-nucleotide deletion in IL18BP, which encodes ...
Belkaya S, Michailidis E, Korol CB, Kabbani M, Cobat A, Bastard P, Lee YS, Hernandez N, Drutman S, de Jong YP, Vivier E, Bruneau J, Béziat V, Boisson B, Lorenzo-Diaz L, Boucherit S, Sebagh M, Jacquemin E, Emile JF, Abel L, Rice CM, Jouanguy E, Casanova JL.   +22 more
europepmc   +6 more sources

Nuclear Transfer using Human CD59 and IL-18BP Double Transgenic Fetal Fibroblasts in Miniature Pigs

Journal of Animal Reproduction and Biotechnology, 2016
Xenotransplantation involves multiple steps of immune rejection. The present study was designed to produce nuclear transfer embryos, prior to the production of transgenic pigs, using fibroblasts carrying transgenes human complement regulatory protein ...
Junghyun Ryu, Minjeong Kim, Jin Seop Ahn, Kwang Sung Ahn, Hosup Shim   +4 more
doaj   +2 more sources

IL-18 and IL-18BP: A Unique Dyad in Health and Disease. [PDF]

Int J Mol Sci
Interleukin-18 (IL-18) serves a dual function in the immune system, acting as a “double-edged sword” cytokine. Depending on the microenvironment and timing, IL-18 can either drive harmful inflammation or restore immune homeostasis. Pathologies characterized by elevated IL-18, recently proposed to be termed IL-18opathies, highlight the therapeutic ...
Novick D.
europepmc   +3 more sources