Results 31 to 40 of about 2,851 (168)

Decoy-resistant IL-18 reshapes the tumor microenvironment and enhances rejection by anti–CTLA-4 in renal cell carcinoma [PDF]

JCI Insight
The cytokine IL-18 has immunostimulatory effects but is negatively regulated by a secreted binding protein, IL-18BP, that limits IL-18’s anticancer efficacy.
David A. Schoenfeld, Dijana Djureinovic, David G. Su, Lin Zhang, Benjamin Y. Lu, Larisa Kamga, Jacqueline E. Mann, John D. Huck, Michael Hurwitz, David A. Braun, Lucia Jilaveanu, Aaron M. Ring, Harriet M. Kluger   +12 more
doaj   +2 more sources

Interleukin-18 Binding Protein (IL-18BP) Deficiency Affects Lymphocyte Activation and IL-18 Expression in a Mouse Model of Liver Inflammation. [PDF]

Eur J Immunol
European Journal of Immunology, Volume 55, Issue 4, April 2025.
Devisme C, Stosskopf M, Piquet-Pellorce C, Palmer G, Gabay C, Seyec JL, Samson M, Raguenes-Nicol C.   +7 more
europepmc   +2 more sources

IL-18 binding protein (IL-18BP) as a novel radiation countermeasure after radiation exposure in mice. [PDF]

Sci Rep, 2020
AbstractRecent studies suggested that radiation exposure causes local and systemic inflammatory responses and induces cell and tissue damage. We have reported that IL-18 plays an important role in radiation-induced injury. Here, we demonstrate that IL-18 binding protein (IL-18BP), a natural antagonist of IL-18, was significantly increased (1.7–63 fold)
Li X, Cui W, Hull L, Wang L, Yu T, Xiao M.   +5 more
europepmc   +4 more sources

Decoy Receptors in Autoimmunity: Molecular Guardians and Pathogenic Players in Immune Dysregulation. [PDF]

Mediators Inflamm
Autoimmune disorders encompass a varied range of diseases in which the immune system mistakenly targets and attacks the body’s own tissues. The causes of the conditions are unknown. It is presumed that various genetic, environmental, and immune factors all play a part.
Farahani H, Kokhaei P, Ganji A, Mosayebi G, Ghazavi A.   +4 more
europepmc   +2 more sources

The Role of Interleukin-1 and Interleukin-18 in Pro-Inflammatory and Anti-Viral Responses to Rhinovirus in Primary Bronchial Epithelial Cells [PDF]

, 2013
Human Rhinovirus (HRV) is associated with acute exacerbations of chronic respiratory disease. In healthy individuals, innate viral recognition pathways trigger release of molecules with direct anti-viral activities and pro-inflammatory mediators which ...
AJ Puren, B Winther, BP Leung, C Elbim, CA Stokes, CJ Chen, CM Freeman, D Proud, D Proud, DC Newcomb, Donna K. Finch, Emmanuel Briend, FM Botelho, H Poeck, Ian Sabroe, J Siednienko, JE Sims, John Ferguson, JR Hurst, K Triantafilou, L Slater, Linda Kay, Lisa C. Parker, M Guma, M Terajima, Matthew A. Sleeman, MR Thompson, N Schmitz, NL Korpi-Steiner, O Gross, O Gross, P Mallia, P Rider, Ralph Tripp, RS Zaheer, SB Greenberg, SE Robertson, Siân C. Piper, SL Johnston, SP Sanders, T Manigold, TA Seemungal, TA Seemungal, X Wang   +43 more
core   +11 more sources

The role of interleukin-18 and interleukin-18 binding protein in K/BxN serum transfer-induced arthritis

Frontiers in Immunology, 2023
BackgroundInterleukin-18 is a proinflammatory cytokine, the activity of which is regulated by its natural inhibitor, IL-18 binding protein (IL-18BP). Elevated circulating levels of IL-18 have been observed in patients with systemic juvenile idiopathic ...
Sebastien Fauteux-Daniel, Sebastien Fauteux-Daniel, Sebastien Fauteux-Daniel, Laura M. Merlo Pich, Laura M. Merlo Pich, Laura M. Merlo Pich, Charlotte Girard-Guyonvarc’h, Charlotte Girard-Guyonvarc’h, Charlotte Girard-Guyonvarc’h, Assunta Caruso, Assunta Caruso, Assunta Caruso, Emiliana Rodriguez, Emiliana Rodriguez, Emiliana Rodriguez, Cem Gabay, Cem Gabay, Cem Gabay   +17 more
doaj   +1 more source

Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases

Biomedicines, 2022
Natural soluble antagonist and decoy receptor on the surface of the cell membrane are evolving as crucial immune system regulators as these molecules are capable of recognizing, binding, and neutralizing (so-called inhibitors) their targeted ligands ...
Seung Yong Park, Yasmin Hisham, Hyun Mu Shin, Su Cheong Yeom, Soohyun Kim   +4 more
doaj   +1 more source

The protective effect of intrasplenic transplantation of Ad-IL-18BP/IL-4 gene-modified fetal hepatocytes on ConA-induced hepatitis in mice. [PDF]

PLoS ONE, 2013
Concanavalin A (ConA)-induced hepatitis is an experimental murine model mirroring the pathology of human autoimmune hepatitis.To investigate the effects of intrasplenically transplanted fetal hepatocytes (BNL.CL2) transfected with recombinant adenovirus ...
Xueting Shao, Yun Qian, Chenhuai Xu, Bo Hong, Wanhong Xu, Ling Shen, Changzhong Jin, Zhigang Wu, Xiangmin Tong, Hangping Yao   +9 more
doaj   +1 more source

IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis

Journal of Translational Medicine, 2021
Background Patients with rheumatoid arthritis (RA) have increased levels of interleukin-18 (IL-18) and decreased levels of IL-18 binding protein (IL-18BP) in the serum and synovial fluid (SF) compared to those in patients with osteoarthritis (OA) or in ...
Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee, Hae-Rim Kim   +5 more
doaj   +1 more source

Pharmacokinetic Study of rhIL-18BP and Its Effect on Radiation-Induced Cytokine Changes in Mouse Serum and Intestine

Toxics, 2022
Administration of recombinant human IL-18 binding protein (rhIL-18BP), a natural antagonist of IL-18, significantly increased mouse survival after lethal doses of irradiation. To further understand the roles of IL-18BP in radiation mitigation, we studied
Wanchang Cui, Lisa Hull, Alex Zizzo, Li Wang, Bin Lin, Min Zhai, Mang Xiao   +6 more
doaj   +1 more source