Results 51 to 60 of about 2,851 (168)
Allergology International, 2008 Background: While interleukin-18 (IL-18) plays an important role in the innate and adaptive immune responses, it can also cause severe allergic inflammatory reactions. Thus it is a molecule currently being targeted for therapy.
Takeshi Kimura +5 more
doaj +1 more source
Interleukin-18 produced by bone marrow- derived stromal cells supports T-cell acute leukaemia progression [PDF]
, 2014 International audienceDevelopment of novel therapies is critical for T-cell acute leukae-mia (T-ALL). Here, we investigated the effect of inhibiting the MAPK/MEK/ERK pathway on T-ALL cell growth. Unexpectedly, MEK inhibitors (MEKi) enhanced growth of 70%
André Baruchel +22 more
core +5 more sources
IL-18BP is decreased in osteoporotic women: Prevents Inflammasome mediated IL-18 activation and reduces Th17 differentiation. [PDF]
Sci Rep, 2016 AbstractIL-18BP is a natural antagonist of pro-inflammatory IL-18 cytokine linked to autoimmune disorders like rheumatoid arthritis. However, its role in post menopausal osteoporosis is still unknown. In this study, we investigated the role of IL-18BP on murine osteoblasts, its effect on osteoblasts-CD4+ T cells and osteoblasts-CD11b+ macrophage co ...
Mansoori MN +9 more
europepmc +4 more sources
iNKT cell regulation of B cell activation in inflammation [PDF]
, 2016 The ability to combat infections through the generation of specific immune responses is critical to our survival. The immune system can react to and combat virtually any molecule presented to it, including those derived from our own body.
Landgraff Hägglöf, Thomas
core +1 more source
T cell immune abnormalities in immune thrombocytopenia [PDF]
, 2014 Immune thrombocytopenia is an autoimmune disease with abnormal T cell immunity. Cytotoxic T cells, abnormal T regulatory cells, helper T cell imbalance, megakaryocyte maturation abnormalities and abnormal T cell anergy are involved in the pathogenesis of
Jun Peng +3 more
core +1 more source
Context-dependent role of IL-18 in cancer biology and counter-regulation by IL-18BP [PDF]
Journal of Leukocyte Biology, 2014 AbstractIL-18 is a proinflammatory and immune regulatory cytokine, member of the IL-1 family. IL-18 was initially identified as an IFN-γ-inducing factor in T and NK cells, involved in Th1 responses. IL-18 is produced as an inactive precursor (pro-IL-18) that is enzymatically processed into a mature form by Casp1.
Marina, Fabbi +2 more
openaire +2 more sources
Cancer Biology & Medicine, 2009 OBJECTIVE To study the relationship between the serum levels of IL-18 and IL-18BP in the development and growth of primary liver cancer, benign liver tumors and liver cirrhosis and to determine the value of serum IL-18 and IL-18BP in the diagnosis of
Xianghui LIAO +2 more
doaj +1 more source
Autoinflammatory periodic fever, immunodeficiency, and thrombocytopenia (PFIT) caused by mutation in actinregulatory gene WDR1 [PDF]
, 2017 The importance of actin dynamics in the activation of the inflammasome is becoming increasingly apparent. IL-1β, which is activated by the inflammasome, is known to be central to the pathogenesis of many monogenic autoinflammatory diseases.
Anderson, G +19 more
core +2 more sources
Biomedicine & Pharmacotherapy, 2023 Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by progressive inflammation and fibrosis around intrahepatic and extrahepatic bile ducts leading to severe hepatic cirrhosis and high mortality. Although there is an urgent clinical unmet need for PSC, no effective medical therapy has been developed to delay the ...
Dong-Hyun Kim +9 more
openaire +2 more sources
Cross-disease innate gene signature: Emerging diversity and abundance in RA comparing to SLE and SSc [PDF]
, 2019 Overactivation of the innate immune system together with the impaired downstream pathway of type I interferon-responding genes is a hallmark of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc).
Fillerová, Regina +8 more
core +1 more source