Results 121 to 130 of about 60,933,508 (232)
مجلة علوم ذي قارAsthma is a persistent inflammatory respiratory disease characterized by coughing, wheezing, and intermittent dyspnea, as well as a sensation of chest tightness.
Ahmed Salman, Hind Jaber, Ekhlas Saddam
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Impact of IL-27 on regulatory T cell responses [PDF]
, 2013 Interleukin (IL)-27 is a heterodimeric cytokine with potent inhibitory properties. Thus, mice that lack IL-27-mediated signaling develop exaggerated inflammatory responses during toxoplasmosis as well as other infections or autoimmune processes.
O\u27Hara, Aisling +1 more
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Characterising interleukin-27 (IL-27) responses in human blood derived macrophage cells [PDF]
Macrophages are key cells in the pathogenesis of chronic inflammatory diseases. Interleukin (IL)-27 is a pleiotropic cytokine with mostly immunoregulatory functions and associated with a wide array of diseases. There is little knowledge on the effects of
Helps, Thomas +8 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Novel Functions of IL-27 in Innate Immunity: Characterization of IL-27-induced Inflammatory Responses in Human Monocytes and Impact of HIV Infection on IL-27 Expression and Function [PDF]
, 2012 Thesis (Ph.D, Microbiology & Immunology) -- Queen's University, 2012-04-12 13:07:50.588Interleukins, cytokines secreted by leukocytes, are predominant messengers modulating immune responses.
Guzzo, Christina
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Il settore Lattanzi della necropoli di Norchia ed il contesto della tomba 3
Il capitolo presenta il contesto e lo scavo della tomba della necropoli dei Lattanzi a Norchia, in cui nel 2024 è stato rinvenuto uno stamnos decorato e ...
Daniel Morleghem
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source