Results 111 to 120 of about 1,340,473 (190)

Targeted IL-27-based gene therapy in preventing SARS-CoV-2 entry. [PDF]

Mol Biol Rep
Mulia GE, Salameh JW, Figueiredo ML.
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Microglial IL-27 modulates depression-like behaviors induced by postnatal immune activation. [PDF]

Cell Rep Med
Qiao X, Li N, Yao Y, Zhang X, Wang Y, Zhang X, Zhao T, Wu D, Liu S, Du J, Wang D, Diao C, Wang L, Cao F, Zhou W, Hao A.   +15 more
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

IL-27: A Double-Edged Sword in Immune Regulation via JAK-STAT Orchestration. [PDF]

J Immunol Res
Zhang X, Feng C, Xu Y, Zeng Y, Luo Q, Qin J, Li T, Peng L, Zhang H, Dai H.   +9 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

IL-27 promotes Treg cell expression of CD122 and fitness at homeostasis. [PDF]

Proc Natl Acad Sci U S A
Lanzar ZR, Aldridge DL, Cruz-Morales E, Howard CA, Conway IO, Zhong Z, Eberhard JN, Pereira JA, Phan AT, Ring AM, Parker M, Kanellopoulou C, Min B, Kedl RM, Christian DA, Hunter CA.   +15 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

IL-27-Ucp2-FoxO3 axis mediating the polarization of alternatively activated macrophages and ameliorating inflammatory pain. [PDF]

Korean J Pain
Ma Y, Gan S, Zheng Y, Kang X, Zhu S.
europepmc   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source