Results 91 to 100 of about 60,933,508 (232)

Increase in CD4+Foxp3+ Regulatory T cells and Amelioration of Experimental Autoimmune Encephalomyelitis in Mice Treated with IL-27

Journal of Mazandaran University of Medical Sciences, 2019
Background and purpose: In multiple sclerosis (MS) and its murine model, experimental autoimmune encephalomyelitis (EAE), chronic inflammation damages the myelin of central nervous system.
Samad Nazemi, Rahim Golmohammadi, Mohsen Naeemipour, Mohammad-Shafi Mojadadi   +3 more
doaj  

T-cell lymphoma-associated STAT3 variants impose a type 1 regulatory-like phenotype

Frontiers in Immunology
STAT3 signaling is fundamental to T cells, where it underlies basic cellular processes like metabolism and apoptosis, as well as specialized processes like effector differentiation and cytokine production.
Aaron B. Schultz, Aaron B. Schultz, Molly Dalzell, Molly Dalzell, Luis Nivelo, Luis Nivelo, Sarah E. Henrickson, Sarah E. Henrickson, Sarah E. Henrickson, Alejandro V. Villarino, Alejandro V. Villarino   +10 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Test characteristics of IL-27.

, 2018
Test characteristics of IL-27.
Hector R. Wong (516379), Matthew Zackoff (6009236), Zachary Berrens (3576161), Lara Danziger-Isakov (6009239), Patrick Lahni (516395), Lauren Jacobs (484900), Erin K. Stenson (6009233)   +6 more
core   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

IL-27 induced IL-18BP activation pathway in HaCat cells.

, 2013
(a) HaCat cells were stimulated for 30 min with IL-27 (100 ng/ml), IFNγ (20 ng/ml) or used as non stimulated control, lysed and the obtained nuclear extract analysed by western blot using antibodies specific for total STAT1 and pSTAT1-Y701.
Heiko Mühl (197457), Malte Bachmann (239722), Rosella Doble (317902), Thomas Werfel (317903), Josef Pfeilschifter (92946), Miriam Wittmann (317901)   +5 more
core   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Study of IL-12 Agonists in Macrophages from Patients with Healing and Non-Healing Forms of Cutaneous leishmaniasis

مجله دانشکده پزشکی اصفهان, 2013
Background: Cutaneous leishmaniasis (CL) is a self-healing disease; however, due to some reasons, in a few cases the lesion develops to a non-healing form of disease.
Sepideh Tolouei, Seyed Hossein Hejazi, Seyed Javad Hasheminia, Reza Arjmand, Ali Khamesipour, Mohamad Ali Nilforoushzadeh   +5 more
doaj