Results 221 to 230 of about 2,017,899 (336)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Expression of IL-4 Receptor Alpha in Ectopic Lymphoid Tissue in Chronic Rhinosinusitis. [PDF]

Allergy
Kanai K, Kusano H, Oka A, Yamada M, Takagi R, Suzaki I, Hirano K, Bai J, Shiomi T, Okano M.   +9 more
europepmc   +1 more source

Il processo di Cremuzio Cordo in Dio LVII, 24, 2-4

, 2016
Martina Bono
openalex   +1 more source

Transcriptional control of the IL-5 gene by human helper T cells: IL-5 synthesis is regulated independently from IL-2 or IL-4 synthesis [PDF]

, 1999
A MORI, Osamu Kaminuma, Takeshi Mikami, Satoshi Inoue, Yasushi Okumura, Kazuo Akiyama, Hirokazu Okudaira   +6 more
openalex   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Berberine suppresses hepatocellular carcinoma progression by blocking IL-4-JAK1-STAT6-mediated M2 polarization of macrophage. [PDF]

Front Pharmacol
Wang P, Zhong Y, Li M, Liang Q, Jiang W, Zhuang M, Ge X, Li H, Zhang Y, Qiao Y, Jiang J, Hu H, Liu W, Qian F, Wang Z, Sun L, Zhang S, Zhou H.   +17 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

IL-18 promotes pancreatic fibrosis via release of IL-4 from pancreatic stellate cells and induces macrophage M2 polarization. [PDF]

Sci Rep
Tu G, Peng C, Xie S, Zheng S, Jiang H, Chen L, Yu X, Li Z.   +7 more
europepmc   +1 more source

SOCS-1/SSI-1-Deficient NKT Cells Participate in Severe Hepatitis through Dysregulated Cross-Talk Inhibition of IFN-γ and IL-4 Signaling In Vivo [PDF]

, 2001
哲治 仲
openalex   +1 more source