Results 51 to 60 of about 11,774,209 (219)

Structural Basis of IL-1 Family Cytokine Signaling

open access: yesFrontiers in Immunology, 2019
Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and adaptive immune systems, mediating inflammation in response to a wide range of stimuli.
James K. Fields   +6 more
doaj   +1 more source

Tangle-tree duality: in graphs, matroids and beyond

open access: yes, 2018
We apply a recent duality theorem for tangles in abstract separation systems to derive tangle-type duality theorems for width-parameters in graphs and matroids. We further derive a duality theorem for the existence of clusters in large data sets.
Diestel, Reinhard, Oum, Sang-il
core   +2 more sources

Marital Investments and Community Involvement: A Test of Coser’s Greedy Marriage Thesis [PDF]

open access: yes, 2016
It is customary to test Coser’s greedy marriage thesis by comparing marital status groups. We propose a new approach that uses the marital dyad as the unit of analysis and examine whether investments in the marital relationship discourage community ...
Dew, Jeffrey, Kim, Young-Il
core  

L'opera a scuola: il 'cosa', il 'come', il 'perché'

open access: yesMusica Docta, 2011
Gli adolescenti che frequentano le nostre scuole hanno poca o nessuna dimestichezza col melodramma, e spesso lo guardano pure con sospetto: avvicinarli a questo mondo, ai suoi soggetti e ai suoi meccanismi di funzionamento e significazione impone una ...
Silvana Chiesa
doaj   +1 more source

Highlighting Interleukin-36 Signalling in Plaque Psoriasis and Pustular Psoriasis

open access: yesActa Dermato-Venereologica, 2017
Plaque psoriasis and pustular psoriasis are overlapping, but distinct, disorders. The therapeutic response to biologics supports the pivotal role of the tumour necrosis alpha (TNF-?)/ interleukin (IL)-23/IL-17/IL-22 axis in the pathogenesis of these ...
Kazuhisa Furue   +8 more
doaj   +1 more source

Higher Order Bias Correcting Moment Equation for M-Estimation and its Higher Order Efficiency [PDF]

open access: yes
This paper studies an alternative bias correction for the M-estimator, which is obtained by correcting the moment equation in the spirit of Firth (1993).
Kyoo il Kim
core   +3 more sources

X- ray crystallography reveals the mechanism of SARS-CoV-2 PLpro dimerization mediated by a DNA-encoded library screening hit [PDF]

open access: yesStructural Dynamics
The COVID-19 pandemic caused by SARS-CoV-2 has devastated global health, revealing an urgent need for novel therapeutics. The papain-like protease (PLpro) is one of two proteases encoded by SARS-CoV-2, representing an attractive drug target due to its ...
Orville Pemberton   +14 more
doaj   +1 more source

Interleukin‐33 (IL‐33): A nuclear cytokine from the IL‐1 family

open access: yesImmunological Reviews, 2018
Interleukin‐33 (IL‐33) is a tissue‐derived nuclear cytokine from the IL‐1 family abundantly expressed in endothelial cells, epithelial cells and fibroblast‐like cells, both during homeostasis and inflammation.
C. Cayrol, J. Girard
semanticscholar   +1 more source

Radiative Transfer Model of Dust Attenuation Curves in Clumpy, Galactic Environments

open access: yes, 2016
The attenuation of starlight by dust in galactic environments is investigated through models of radiative transfer in a spherical, clumpy ISM. Extinction properties for MW, LMC, and SMC dust types are considered.
Draine, Bruce T., Seon, Kwang-Il
core   +1 more source

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.

open access: yesCancer Cell, 2009
Colitis-associated cancer (CAC) is the most serious complication of inflammatory bowel disease. Proinflammatory cytokines have been suggested to regulate preneoplastic growth during CAC tumorigenesis.
S. Grivennikov   +10 more
semanticscholar   +1 more source

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