Results 61 to 70 of about 11,774,209 (219)
The Immunologic Role of IL-17 in Psoriasis and Psoriatic Arthritis Pathogenesis
Clinical reviews in allergy and immunology, 2018 Psoriasis is a chronic, immune-mediated, inflammatory disease that is pathogenically driven by proinflammatory cytokines. This article reviews the immunologic role of interleukin (IL)-17, the major effector cytokine in the pathogenesis of psoriatic ...
A. Blauvelt, A. Chiricozzi
semanticscholar +1 more source
Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes
Frontiers in Immunology, 2018 Interleukin (IL)-4 and IL-13 are related cytokines that regulate many aspects of allergic inflammation. They play important roles in regulating the responses of lymphocytes, myeloid cells, and non-hematopoietic cells.
I. Junttila
semanticscholar +1 more source
Advancing Crystallography Research: The Latest Progress and Future Directions of NE-CAT Beamlines at the Advanced Photon Source [PDF]
Structural DynamicsThe Northeastern Collaborative Access Team (NE-CAT) develops and operates advanced synchrotron X-ray beamlines to support high-impact structural biology research.
Ali Kaya +12 more
doaj +1 more source
Cytokines in Allergic Conjunctivitis: Unraveling Their Pathophysiological Roles
LifeAllergic conjunctivitis is one of the common immune hypersensitivity disorders that affect the ocular system. The clinical manifestations of this condition exhibit variability contingent upon environmental factors, seasonal dynamics, and genetic ...
DeGaulle I. Chigbu +3 more
doaj +1 more source
Blood Advances, 2017 : Ibrutinib has generated remarkable responses in patients with chronic lymphocytic leukemia (CLL), including those with an unfavorable cytogenetic profile.
Sabah Kadri +23 more
doaj +1 more source
De novo design of potent and selective mimics of IL-2 and IL-15
Nature, 2019 We describe a de novo computational approach for designing proteins that recapitulate the binding sites of natural cytokines, but are otherwise unrelated in topology or amino acid sequence.
Daniel‐Adriano Silva +24 more
semanticscholar +1 more source
Allergy. European Journal of Allergy and Clinical Immunology, 2019 Dupilumab, a fully human monoclonal antibody that binds IL‐4Rα and inhibits signaling of both IL‐4 and IL‐13, has shown efficacy across multiple diseases with underlying type 2 signatures and is approved for treatment of asthma, atopic dermatitis, and ...
A. Le Floc’h +18 more
semanticscholar +1 more source
Journal of Clinical and Translational Science, 2017 OBJECTIVES/SPECIFIC AIMS: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease in the United States and increases risk for cirrhosis and liver cancer.
Lisa B. VanWagner +11 more
doaj +1 more source
Discovery of the IL-23/IL-17 Signaling Pathway and the Treatment of Psoriasis
Journal of Immunology, 2018 Psoriasis vulgaris is a common, heterogeneous, chronic inflammatory skin disease characterized by thickened, red, scaly plaques and systemic inflammation.
J. Hawkes, B. Yan, T. Chan, J. Krueger
semanticscholar +1 more source