Results 1 to 10 of about 15,917 (145)

Solvent-Free and Microwave-Assisted Synthesis Enables Formation of Imidazole and Pyrazole Derivatives Through Epoxide Ring Opening [PDF]

Molecules
A solvent-free, microwave-assisted approach for the ring-opening reactions of phenyl glycidyl ether with a series of commercially available imidazoles and pyrazoles is described. Microwave irradiation allows reactions to proceed rapidly.
MaryGrace McAfee, Joshua Pack, Brian Walker   +2 more
doaj   +2 more sources

GO/MNPs–TEA–CuI in water: a green and efficient catalytic system for multicomponent preparation of highly substituted imidazoles and oxazoles [PDF]

Frontiers in Chemistry
A sustainable and highly efficient catalytic protocol has been developed employing graphene oxide-supported magnetic nanoparticles functionalized with triethanolamine and copper(I) iodide (GO/MNPs–TEA–CuI) for the synthesis of functionalized imidazole ...
Mohamed Abu Shuheil, Ahmed Aldulaimi, Rekha M. M., Subhashree Ray, Omayma Salim Waleed, C. P. Surya, Renu Sharma, Vatsal Jain   +7 more
doaj   +2 more sources

Electrochemically Induced Synthesis of Imidazoles from Vinyl Azides and Benzyl Amines

Molecules, 2022
An electrochemically induced synthesis of imidazoles from vinyl azides and benzyl amines was developed. A wide range of imidazoles were obtained, with yields of 30 to 64%.
Vera A. Vil’, Sergei S. Grishin, Alexander O. Terent’ev   +2 more
doaj   +1 more source

One-step synthesis of imidazoles from Asmic (anisylsulfanylmethyl isocyanide)

Beilstein Journal of Organic Chemistry, 2021
Substituted imidazoles are readily prepared by condensing the versatile isocyanide Asmic, anisylsulfanylmethylisocyanide, with nitrogenous π-electrophiles.
Louis G. Mueller, Allen Chao, Embarek AlWedi, Fraser F. Fleming   +3 more
doaj   +1 more source

Design, Synthesis and Biological Evaluation of Imidazole-Substituted/Fused Aryl Derivatives Targeting Tubulin Polymerization as Anticancer Agents

SynOpen, 2023
The development of new pharmacologically active molecules targeting tubulin polymerization has recently attracted great interest in research groups. In efforts to develop new potent anticancer compounds, imidazole-tethered/fused pharmacologically active ...
Kapil Kumar Goel, Satyendra Kumar Rajput, Rajeev Kharb   +2 more
doaj   +1 more source

Exploration of Benzenesulfonamide-Bearing Imidazole Derivatives Activity in Triple-Negative Breast Cancer and Melanoma 2D and 3D Cell Cultures

Pharmaceuticals, 2021
Heterocyclic compounds are one of the main groups of organic compounds possessing wide range of applications in various areas of science and their derivatives are present in many bioactive structures. They display a wide variety of biological activities.
Benas Balandis, Vytautas Mickevičius, Vilma Petrikaitė   +2 more
doaj   +1 more source

Metal-Free Eliminative C-H Arylthiolation of 2H-Imidazole N-Oxides with Thiophenols

Chemistry, 2023
A synthetic strategy based on reactions of cyclic imine oxides, namely 2H-imidazole 1-oxides, with thiophenols mediated by acetyl chloride was successfully applied as a convenient tool to obtain a series of novel azaheterocyclic molecules, including ...
Egor A. Nikiforov, Nailya F. Vaskina, Timofey D. Moseev, Mikhail V. Varaksin, Valery N. Charushin, Oleg N. Chupakhin   +5 more
doaj   +1 more source

Synthesis of Novel Benzenesulfonamide-Bearing Functionalized Imidazole Derivatives as Novel Candidates Targeting Multidrug-Resistant Mycobacterium abscessus Complex

Microorganisms, 2023
Infections caused by drug-resistant (DR) Mycobacterium abscessus (M. abscessus) complex (MAC) are an important public health concern, particularly when affecting individuals with various immunodeficiencies or chronic pulmonary diseases.
Benas Balandis, Povilas Kavaliauskas, Birutė Grybaitė, Vidmantas Petraitis, Rūta Petraitienė, Ethan Naing, Andrew Garcia, Ramunė Grigalevičiūtė, Vytautas Mickevičius   +8 more
doaj   +1 more source

Use of DNA‐alkylating pyrrole‐imidazole polyamides for anti‐cancer drug sensitivity screening in pancreatic ductal adenocarcinoma

Cancer Medicine, 2023
Background Activating mutations of the KRAS occurs in >90% of pancreatic ductal adenocarcinoma (PDAC) cases. However, direct pharmacological targeting of the activated KRAS protein has been challenging.
Akiko Tsujimoto, Niina Matsuo, Xiaoyi Lai, Takahiro Inoue, Hiroyuki Yoda, Jason Lin, Yoshinao Shinozaki, Takayoshi Watanabe, Nobuko Koshikawa, Atsushi Takatori, Hiroki Nagase   +10 more
doaj   +1 more source

The Structure of Biologically Active Functionalized Azoles: NMR Spectroscopy and Quantum Chemistry

Magnetochemistry, 2022
This review summarizes the data on the stereochemical structure of functionalized azoles (pyrazoles, imidazoles, triazoles, thiazoles, and benzazoles) and related compounds obtained by multipulse and multinuclear 1H, 13C, 15N NMR spectroscopy and quantum
Lyudmila I. Larina
doaj   +1 more source