Solvent-Free and Microwave-Assisted Synthesis Enables Formation of Imidazole and Pyrazole Derivatives Through Epoxide Ring Opening [PDF]
MoleculesA solvent-free, microwave-assisted approach for the ring-opening reactions of phenyl glycidyl ether with a series of commercially available imidazoles and pyrazoles is described. Microwave irradiation allows reactions to proceed rapidly.
MaryGrace McAfee +2 more
doaj +2 more sources
Benzylic C–H Oxidation: Recent Advances and Applications in Heterocyclic Synthesis [PDF]
MoleculesBenzylic C–H oxidation to form carbonyl compounds, such as ketones, is a fundamental transformation in organic synthesis as it allows for the preparation of versatile intermediates.
Nonhlelo Majola, Vineet Jeena
doaj +2 more sources
Synthesis of Functionalized 1H-Imidazoles via Denitrogenative Transformation of 5-Amino-1,2,3-Triazoles [PDF]
MoleculesAn efficient access to novel 2-substituted 1H-imidazole derivatives was developed based on acid-mediated denitrogenative transformation of 5-amino-1,2,3-triazole derivatives available through dipolar azide−nitrile cycloaddition (DCR).
Pavel S. Gribanov +7 more
doaj +2 more sources
Lower micromolar activity of the antifungal imidazoles on the bacterial-type bifunctional aldehyde/alcohol dehydrogenase (AdhE) in Cryptosporidium parvum and in vitro efficacy against the zoonotic parasite [PDF]
International Journal for Parasitology: Drugs and Drug ResistanceCryptosporidium parvum is a waterborne and foodborne zoonotic protozoan parasite, a causative agent of moderate to severe diarrheal diseases in humans and animals. However, fully effective treatments are unavailable for medical and veterinary uses. There
Haichuan Chen +6 more
doaj +2 more sources
SynOpen, 2023 The development of new pharmacologically active molecules targeting tubulin polymerization has recently attracted great interest in research groups. In efforts to develop new potent anticancer compounds, imidazole-tethered/fused pharmacologically active ...
Kapil Kumar Goel +2 more
doaj +1 more source
One-step synthesis of imidazoles from Asmic (anisylsulfanylmethyl isocyanide)
Beilstein Journal of Organic Chemistry, 2021 Substituted imidazoles are readily prepared by condensing the versatile isocyanide Asmic, anisylsulfanylmethylisocyanide, with nitrogenous π-electrophiles.
Louis G. Mueller +3 more
doaj +1 more source
Elucidating the proton transport pathways in liquid imidazole with first-principles molecular dynamics [PDF]
J. Phys. Chem. Lett. 11 (2020) 6156-6163, 2021 Imidazole is a promising anhydrous proton conductor with a high conductivity comparable to that of water at a similar temperature relative to its melting point. Previous theoretical studies of the mechanism of proton transport in imidazole have relied either on empirical models or on ab initio trajectories that have been too short to draw significant ...
arxiv +1 more source
Fruit juices act as biocatalysts in the efficient synthesis of potentially bioactive imidazoles
Green Chemistry Letters and Reviews, 2022 An efficient and eco-friendly itinerary has been carried out for the synthesis of imidazole derivatives (3a–3h) from the reactions between substituted aldehydes (1a–1h), benzil (2a), and ammonium acetate (2b) in Citrus limon L.
Susheel Gulati +2 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2020 We report that phenacyl azides are key compounds for a regiodivergent synthesis of valuable, functionalized imidazole (32–98% yield) and pyrimidine derivatives (45–88% yield), with a broad substrate scope, when using deep eutectic solvents [choline ...
Paola Vitale +5 more
doaj +1 more source
The Structure of Biologically Active Functionalized Azoles: NMR Spectroscopy and Quantum Chemistry
Magnetochemistry, 2022 This review summarizes the data on the stereochemical structure of functionalized azoles (pyrazoles, imidazoles, triazoles, thiazoles, and benzazoles) and related compounds obtained by multipulse and multinuclear 1H, 13C, 15N NMR spectroscopy and quantum
Lyudmila I. Larina
doaj +1 more source