Results 1 to 10 of about 95,350 (343)

Solvent-Free and Microwave-Assisted Synthesis Enables Formation of Imidazole and Pyrazole Derivatives Through Epoxide Ring Opening [PDF]

Molecules
A solvent-free, microwave-assisted approach for the ring-opening reactions of phenyl glycidyl ether with a series of commercially available imidazoles and pyrazoles is described. Microwave irradiation allows reactions to proceed rapidly.
MaryGrace McAfee, Joshua Pack, Brian Walker   +2 more
doaj   +2 more sources

Lower micromolar activity of the antifungal imidazoles on the bacterial-type bifunctional aldehyde/alcohol dehydrogenase (AdhE) in Cryptosporidium parvum and in vitro efficacy against the zoonotic parasite [PDF]

International Journal for Parasitology: Drugs and Drug Resistance
Cryptosporidium parvum is a waterborne and foodborne zoonotic protozoan parasite, a causative agent of moderate to severe diarrheal diseases in humans and animals. However, fully effective treatments are unavailable for medical and veterinary uses. There
Haichuan Chen, Dongqiang Wang, Chenchen Wang, Peng Jiang, Mingxiao Liu, Jigang Yin, Yonglan Yu   +6 more
doaj   +2 more sources

Benzylic C–H Oxidation: Recent Advances and Applications in Heterocyclic Synthesis [PDF]

Molecules
Benzylic C–H oxidation to form carbonyl compounds, such as ketones, is a fundamental transformation in organic synthesis as it allows for the preparation of versatile intermediates.
Nonhlelo Majola, Vineet Jeena
doaj   +2 more sources

Imidazoles as Potential Anticancer Agents: An Update on Recent Studies

Molecules, 2021
Nitrogen-containing heterocyclic rings are common structural components of marketed drugs. Among these heterocycles, imidazole/fused imidazole rings are present in a wide range of bioactive compounds.
Pankaj Sharma, C. LaRosa, Janet Antwi, Rajgopal Govindarajan, K. Werbovetz   +4 more
semanticscholar   +1 more source

Carbene and photocatalyst-catalyzed decarboxylative radical coupling of carboxylic acids and acyl imidazoles to form ketones

Nature Communications, 2021
The carbene and photocatalyst co-catalyzed radical coupling of acyl electrophile and a radical precursor is emerging as attractive method for ketone synthesis.
Shi-Chao Ren, Xing Yang, Bivas Mondal, Chengli Mou, Weiyi Tian, Zhichao Jin, Y. Chi   +6 more
semanticscholar   +1 more source

Electrochemically Induced Synthesis of Imidazoles from Vinyl Azides and Benzyl Amines

Molecules, 2022
An electrochemically induced synthesis of imidazoles from vinyl azides and benzyl amines was developed. A wide range of imidazoles were obtained, with yields of 30 to 64%.
Vera A. Vil’, Sergei S. Grishin, Alexander O. Terent’ev   +2 more
doaj   +1 more source

One-step synthesis of imidazoles from Asmic (anisylsulfanylmethyl isocyanide)

Beilstein Journal of Organic Chemistry, 2021
Substituted imidazoles are readily prepared by condensing the versatile isocyanide Asmic, anisylsulfanylmethylisocyanide, with nitrogenous π-electrophiles.
Louis G. Mueller, Allen Chao, Embarek AlWedi, Fraser F. Fleming   +3 more
doaj   +1 more source

Design, Synthesis and Biological Evaluation of Imidazole-Substituted/Fused Aryl Derivatives Targeting Tubulin Polymerization as Anticancer Agents

SynOpen, 2023
The development of new pharmacologically active molecules targeting tubulin polymerization has recently attracted great interest in research groups. In efforts to develop new potent anticancer compounds, imidazole-tethered/fused pharmacologically active ...
Kapil Kumar Goel, Satyendra Kumar Rajput, Rajeev Kharb   +2 more
doaj   +1 more source

Magnetic nanoparticle-supported sulfonic acid as a green catalyst for the one-pot synthesis of 2,4,5-trisubstituted imidazoles and 1,2,4,5-tetrasubstituted imidazoles under solvent-free conditions

Heterocyclic Communications, 2021
In this work, magnetic nanoparticle-supported sulfonic acid (γ-Fe2O3-SO3H) is used as an efficient catalyst in the synthesis of 2,4,5-trisubstituted imidazoles and 1,2,4,5-tetrasubstituted imidazoles in a short time (40–70 min for trisubstituted ...
Mahnaz Sakhdari, A. Amoozadeh, E. Kolvari   +2 more
semanticscholar   +1 more source

Recent advances in the synthesis of imidazoles.

Organic and biomolecular chemistry, 2020
The review highlights the recent advances (2018-present) in the regiocontrolled synthesis of substituted imidazoles. These heterocycles are key components to functional molecules that are used in a variety of everyday applications.
D. Shabalin, J. Camp
semanticscholar   +1 more source