Results 11 to 20 of about 95,350 (343)

Exploration of Benzenesulfonamide-Bearing Imidazole Derivatives Activity in Triple-Negative Breast Cancer and Melanoma 2D and 3D Cell Cultures

Pharmaceuticals, 2021
Heterocyclic compounds are one of the main groups of organic compounds possessing wide range of applications in various areas of science and their derivatives are present in many bioactive structures. They display a wide variety of biological activities.
Benas Balandis, Vytautas Mickevičius, Vilma Petrikaitė   +2 more
doaj   +1 more source

Metal-Free Eliminative C-H Arylthiolation of 2H-Imidazole N-Oxides with Thiophenols

Chemistry, 2023
A synthetic strategy based on reactions of cyclic imine oxides, namely 2H-imidazole 1-oxides, with thiophenols mediated by acetyl chloride was successfully applied as a convenient tool to obtain a series of novel azaheterocyclic molecules, including ...
Egor A. Nikiforov, Nailya F. Vaskina, Timofey D. Moseev, Mikhail V. Varaksin, Valery N. Charushin, Oleg N. Chupakhin   +5 more
doaj   +1 more source

Synthesis of Novel Benzenesulfonamide-Bearing Functionalized Imidazole Derivatives as Novel Candidates Targeting Multidrug-Resistant Mycobacterium abscessus Complex

Microorganisms, 2023
Infections caused by drug-resistant (DR) Mycobacterium abscessus (M. abscessus) complex (MAC) are an important public health concern, particularly when affecting individuals with various immunodeficiencies or chronic pulmonary diseases.
Benas Balandis, Povilas Kavaliauskas, Birutė Grybaitė, Vidmantas Petraitis, Rūta Petraitienė, Ethan Naing, Andrew Garcia, Ramunė Grigalevičiūtė, Vytautas Mickevičius   +8 more
doaj   +1 more source

Use of DNA‐alkylating pyrrole‐imidazole polyamides for anti‐cancer drug sensitivity screening in pancreatic ductal adenocarcinoma

Cancer Medicine, 2023
Background Activating mutations of the KRAS occurs in >90% of pancreatic ductal adenocarcinoma (PDAC) cases. However, direct pharmacological targeting of the activated KRAS protein has been challenging.
Akiko Tsujimoto, Niina Matsuo, Xiaoyi Lai, Takahiro Inoue, Hiroyuki Yoda, Jason Lin, Yoshinao Shinozaki, Takayoshi Watanabe, Nobuko Koshikawa, Atsushi Takatori, Hiroki Nagase   +10 more
doaj   +1 more source

The Structure of Biologically Active Functionalized Azoles: NMR Spectroscopy and Quantum Chemistry

Magnetochemistry, 2022
This review summarizes the data on the stereochemical structure of functionalized azoles (pyrazoles, imidazoles, triazoles, thiazoles, and benzazoles) and related compounds obtained by multipulse and multinuclear 1H, 13C, 15N NMR spectroscopy and quantum
Lyudmila I. Larina
doaj   +1 more source

One-pot synthesis of 2,4,5-trisubstituted imidazole derivatives catalyzed by btppc under solvent-free conditions

Bulletin of the Chemical Society of Ethiopia, 2017
A simple and efficient method for one-pot synthesis of lophine derivatives (2,4,5-trisubstituted imidazoles) by using the benzyltriphenylphosphonium chloride (BTPPC), as a catalyst, under solvent-free conditions is described.
M. Alikarami, M. Amozad
doaj   +1 more source

Regiodivergent synthesis of functionalized pyrimidines and imidazoles through phenacyl azides in deep eutectic solvents

Beilstein Journal of Organic Chemistry, 2020
We report that phenacyl azides are key compounds for a regiodivergent synthesis of valuable, functionalized imidazole (32–98% yield) and pyrimidine derivatives (45–88% yield), with a broad substrate scope, when using deep eutectic solvents [choline ...
Paola Vitale, Luciana Cicco, Ilaria Cellamare, Filippo M. Perna, Antonio Salomone, Vito Capriati   +5 more
doaj   +1 more source

An Updated Review on the Synthesis and Antibacterial Activity of Molecular Hybrids and Conjugates Bearing Imidazole Moiety

Molecules, 2020
The rapid growth of serious infections caused by antibiotic resistant bacteria, especially the nosocomial ESKAPE pathogens, has been acknowledged by Governments and scientists and is one of the world’s major health problems.
Renzo Rossi, Maurizio Ciofalo
doaj   +1 more source

2-[(1H-Imidazol-2-yl)disulfanyl]-1H-imidazole [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
In the title molecule, C(6)H(6)N(4)S(2), a twofold rotation axis passes through the mid-point of the S-S bond. The C-S-S-C torsion angle is 83.62 (17)°. π-π stacking between imidazole rings of adjacent mol-ecules is observed in the crystal structure, the centroid-centroid distance being 3.447 (2) Å. Inter-molecular N-H⋯S hydrogen bonding results in the
Hamid Reza Khavasi, Soheila Naderi, Laleh Talavat, Mona Feizbakhsh Bazargani   +3 more
openaire   +3 more sources

Visible-light-driven Photocatalytic N-arylation of Imidazole Derivatives and Arylboronic Acids on Cu/graphene catalyst

Scientific Reports, 2015
N-aryl imidazoles play an important role as structural and functional units in many natural products and biologically active compounds. Herein, we report a photocatalytic route for the C-N cross-coupling reactions over a Cu/graphene catalyst, which can ...
Yan-Li Cui, Xiao-Ning Guo, Ying-Yong Wang, Xiang-Yun Guo   +3 more
doaj   +1 more source