Results 211 to 220 of about 95,350 (343)

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

open access: yesAdvanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao   +16 more
wiley   +1 more source

Synthetic Strategies to Access Fluorinated Azoles. [PDF]

open access: yesEuropean J Org Chem
El-Gaber MKA   +4 more
europepmc   +1 more source

Hierarchically Porous Nitrogen‐Doped Carbon with High Conductivity for Rapid and Efficient Cr(VI) Reduction

open access: yesAdvanced Science, EarlyView.
The d‐PNC(1100, 10%) catalyst, synthesized via a zinc‐based ionic liquid self‐sacrificing pore‐forming strategy to create a defect‐rich, hierarchical, nitrogen‐doped porous structure, enhances conductivity, promotes rapid mass transfer and synergistic catalytic activity, driving efficient Cr(VI) reduction in OA solution to generate Cr(III)‐OA complexes.
Danyan Lin   +7 more
wiley   +1 more source

CsdA‐LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis

open access: yesAdvanced Science, EarlyView.
This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song   +14 more
wiley   +1 more source

Gutmann Donor Theory‐Guided Design of Mononuclear Ionic Cluster for Exceptional N‐Type Thermoelectric Ionogel

open access: yesAdvanced Science, EarlyView.
Super‐stretchable and self‐healing polyacrylate ternary ionogel elastomers are used for flexible i‐TE devices. Based on Gutmann donor theory of doped anion, the work proposes a three‐parameter tuning strategy of flexible polymer‐doped anion‐synergistic cation to achieve the systematic design of ionic thermoelectric materials. Abstract Quasi‐solid‐state,
Bin Chen   +9 more
wiley   +1 more source

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