Oral supplement in healthy older adults to support physical fitness and mental wellbeing [PDF]
Frontiers in NutritionIntroductionCucumbers have been anecdotally credited with anti-inflammatory properties. IdoBR1 [(2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid], an iminosugar amino acid isolated from the fruits of certain cucumbers (Cucumis sativus ...
Amanda J. Lloyd +8 more
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Borylated 5-Membered Ring Iminosugars: Synthesis and Biological Evaluation for Glycosidase Inhibition and Anticancer Properties for Application in Boron Neutron Capture Therapy (BNCT)—Part 2 [PDF]
PharmaceuticalsBackground: The synthesis and biological investigation of pyrrolidine (L-gulo) iminosugars bearing an organic boron pharmacophore in ortho and meta positions of an N-benzyl group is reported.
Kate Prichard +9 more
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Iminosugars of the Invasive Arboreal Amorpha fruticosa and Glycosidase Inhibition Potential [PDF]
PlantsAmorpha fruticosa L. (Fabaceae) originates from North America and has become an aggressive invasive plant in many parts of the world. It affects the local biodiversity in many negative ways. Our previous in vivo tests of purified extract of A.
Robert J. Nash +3 more
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Borylated Five-Membered Ring Iminosugars: Synthesis, Spectroscopic Analysis, and Biological Evaluation for Glycosidase Inhibition and Anticancer Properties for Application in Boron Neutron Capture Therapy (BNCT)—Part 1 [PDF]
PharmaceuticalsBackground/Objectives: This article reports pyrrolidine iminosugars of L-gulose absolute stereochemical configuration that are functionalised via N-alkylation to bear boronate ester and boronic acid pharmacophores.
Kate Prichard +9 more
doaj +2 more sources
Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents [PDF]
Pharmaceutics, 2023 The nicotinamide phosphoribosyltransferase (NAMPT) is considered a very promising therapeutic target because it is overexpressed in pancreatic cancer.
Irene Conforti +5 more
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PDIA iminosugar influence on subcutaneous Staphylococcus aureus and Pseudomonas aeruginosa infections in mice [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionBiofilm-associated infections persist as a therapeutic challenge in contemporary medicine. The efficacy of antibiotic therapies is ineffective in numerous instances, necessitating a heightened focus on exploring novel anti-biofilm medical ...
Łucja Kozień +11 more
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Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising α-Glucosidase Inhibitors [PDF]
Molecules, 2022 A series of N-substituted iminosugar C-glycosides were synthesized and tested for α-glucosidase inhibition. The results suggested that 6e is a promising and potent α-glucosidase inhibitor.
Haibo Wang +5 more
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Targeting N-Acetylglucosaminidase in Staphylococcus aureus with Iminosugar Inhibitors [PDF]
AntibioticsBacteria are capable of remarkable adaptations to their environment, including undesirable bacterial resistance to antibacterial agents. One of the most serious cases is an infection caused by multidrug-resistant Staphylococcus aureus, which has ...
Janja Sluga +9 more
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Transcriptomic Analysis of Biofilm Formation Inhibition by PDIA Iminosugar in Staphylococcus aureus [PDF]
AntibioticsBackground: Iminosugars are natural or synthetic sugar analogues with a very broad spectrum of activities, including those against the most prominent bacterial pathogens, like P. aeruginosa or S. aureus.
Anna Tomusiak-Plebanek +6 more
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A Bis-Glycosylamine Strategy for the Synthesis of Dimeric Iminosugars Based on a DAB-1 Scaffold [PDF]
MoleculesA straightforward synthetic route towards DAB-1 scaffolded dimeric iminosugars is described here, starting from readily available bis-glycosylamines.
Kamilia Ould Lamara +5 more
doaj +2 more sources