Results 171 to 180 of about 2,892 (197)

Iminosugars: potential inhibitors of liver glycogen phosphorylase

Bioorganic & Medicinal Chemistry, 2001
The first synthesis of the single isomers (3R,4R,5R); (3S,4S,5S): (3R,4R,5S) and (3S,4S,5R) of 5-hydroxymethyl-piperidine-3,4-diol from Arecolin is reported, including the synthesis of a series of N-substituted derivatives of the (3R,4R,5R)-isomer (Isofagomine).
P, Jakobsen, J M, Lundbeck, M, Kristiansen, J, Breinholt, H, Demuth, J, Pawlas, M P, Candela, B, Andersen, N, Westergaard, K, Lundgren, N, Asano   +10 more
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Synthetic Access to the First Spirocyclopropyl Iminosugar

Synlett, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Christophe Laroche, Richard Plantier‐Royon, Jan Szymoniak, Philippe Bertus, Jean‐Bernard Behr   +4 more
openaire   +1 more source

Iminosugar–ferrocene conjugates as potential anticancer agents

Organic & Biomolecular Chemistry, 2012
We prepared a series of new iminosugar-ferrocene hybrids displaying potent inhibition of fucosidase (bovine kidney) and inactivation of MDA-MB-231 breast cancer cells proliferation at low micromolar concentrations. The synthetic route brought to light an unprecedented isomerisation of a 2-ethanalylpyrrolidine.
Audrey, Hottin, Faustine, Dubar, Agata, Steenackers, Philippe, Delannoy, Christophe, Biot, Jean-Bernard, Behr   +5 more
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Aziridination of Cyclic Nitrones Targeting Constrained Iminosugars

Organic Letters, 2017
Rare C-7-substituted aziridinyl iminosugars can be synthesized through a short reaction sequence involving 1,3-cycloaddition of cyclic nitrones with alkynes and a Baldwin rearrangement of isoxazolines into bicyclic 2-acylaziridines. The method is efficient and completely diastereoselective, producing stable aziridinyl iminosugars in high yields.
Salia Tangara, Clara Aupic, Alice Kanazawa, Jean-François Poisson, Sandrine Py   +4 more
openaire   +3 more sources

gem-Diamine 1-N-Iminosugars and Related Iminosugars, Candidate of Therapeutic Agents for Tumor Metastasis

Current Topics in Medicinal Chemistry, 2003
Cancer metastasis is one of the major challenges in cancer research. Inhibitors of tumor metastasis are rapidly emerging as important new drug candidates for cancer therapy. Tumor metastasis formation occurs via a complex multistage process which involves a crucial step of tumor invasion through the basement membrane.
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Iminosugars past, present and future: medicines for tomorrow

Drug Discovery Today, 2011
Iminosugars comprise the most attractive class of carbohydrate mimetics reported to date and are ideally positioned to take advantage of our increasing understanding of glycobiology in the search for new medicines. First-generation iminosugar drugs suffered from lack of adequate selectivity, resulting in considerable side-effects in the clinic. Current
Graeme, Horne, Francis X, Wilson, Jon, Tinsley, David H, Williams, Richard, Storer   +4 more
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ChemInform Abstract: General Strategies for the Synthesis of Iminosugars and New Approaches Towards Iminosugar Libraries

ChemInform, 2009
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Barbara La Ferla, Laura Cipolla, Francesco Nicotra   +2 more
openaire   +1 more source

Synthesis of multivalent iminosugars

2012
comunicazione ...
CARDONA, FRANCESCA, D'ADAMIO, GIAMPIERO, MATASSINI, CAMILLA, GOTI, ANDREA   +3 more
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[Iminosugars: current and future therapeutic applications].

Annales pharmaceutiques francaises, 2007
The replacement of the oxygen-containing ring (pyranose, furanose) of monosaccharides by a nitrogen-containing ring (pyrrolidine, piperidine) leads to a particularly interesting class of glycomimetics: iminosugars. The first synthesis of such a sugar analog by Prof. H.
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General strategies for the synthesis of iminosugars and new approaches towards iminosugar libraries

2007
This chapter will provide an up-to-date review of synthetic methods for the preparation of iminosugars and related compounds. Iminosugars are still the object of intense synthetic investigations, both for the improvement of the synthetic methods and for the preparation of novel structures. Strategies from both sugars and non-carbohydrate precursors can
LA FERLA, BARBARA, CIPOLLA, LAURA FRANCESCA, NICOTRA, FRANCESCO   +2 more
openaire   +1 more source