Iminosugar antivirals: the therapeutic sweet spot [PDF]
Biochemical Society Transactions, 2017 Many viruses require the host endoplasmic reticulum protein-folding machinery in order to correctly fold one or more of their glycoproteins. Iminosugars with glucose stereochemistry target the glucosidases which are key for entry into the glycoprotein folding cycle.
Alonzi, D +3 more
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Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases [PDF]
, 2016 Lysosomal storage disorders (LSDs) are often caused by mutations that destabilize native folding and impair the trafficking of enzymes, leading to premature endoplasmic reticulum (ER)-associated degradation, deficiencies of specific hydrolytic functions ...
García-Fernández, José Manuel +2 more
core +1 more source
Molecules, 2021 Among carbohydrate-processing enzymes, Jack bean α-mannosidase (JBα-man) is the glycosidase with the best responsiveness to the multivalent presentation of iminosugar inhitopes.
Costanza Vanni +9 more
doaj +1 more source
Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry [PDF]
, 2018 The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in situ biological evaluation toward α -galactosidases has been carried out.
Carmona Asenjo, Ana Teresa +8 more
core +1 more source
Molecules, 2021 An efficient method for the synthesis of nojirimycin- and pyrrolidine-based iminosugar derivatives has been developed. The strategy is based on the partial reduction in sugar-derived lactams by Schwartz’s reagent and tandem stereoselective nucleophilic ...
Piotr Szcześniak +2 more
doaj +1 more source
Non-iminosugar glucocerebrosidase small molecule chaperones [PDF]
Med. Chem. Commun., 2012 Small molecule chaperones are a promising therapeutic approach for the Lysosomal Storage Disorders (LSDs). Here, we report the discovery of a new series of non-iminosugar glucocerebrosidase inhibitors with chaperone capacity, and describe their structure activity relationship (SAR), selectivity, cell activity phamacokinetics.
Juan Jose, Marugan +12 more
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Correction: Iminosugars as glycosyltransferase inhibitors
Organic & Biomolecular Chemistry, 2021 Correction for ‘Iminosugars as glycosyltransferase inhibitors’ by Irene Conforti, et al., Org. Biomol. Chem., 2021, DOI: 10.1039/D1OB00382H.
Irene Conforti, Alberto Marra
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Iminosugar 1-Deoxynojirimycin (DNJ) sebagai Antiviral Infeksi Virus Dengue
Keluwih, 2020 — Dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) caused by the DENV virus are among the global problems regarding mosquito-borne viral infections.
Muhammad Luthfi Adnan
doaj +1 more source
Iminosugar inhibitors of carbohydrate-active enzymes that underpin cereal grain germination and endosperm metabolism [PDF]
, 2016 Starch is a major energy store in plants. It provides most of the calories in the human diet and, as a bulk commodity, it is used across broad industry sectors.
Alison M. Smith +57 more
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Crystal structure of 6-azido-6-deoxy-1,2-O-isopropylidene-α-d-glucofuranose
Acta Crystallographica Section E: Crystallographic Communications, 2020 Short syntheses to high Fsp3 index natural-product analogues such as iminosugars are of paramount importance in the investigation of their biological activities and reducing the use of protecting groups is an advantageous synthetic strategy.
Adam Wood +3 more
doaj +1 more source