Results 31 to 40 of about 2,892 (197)

Low-generation dendrimers with a calixarene core and based on a chiral C2-symmetric pyrrolidine as iminosugar mimics

Beilstein Journal of Organic Chemistry, 2012
The preparation of low-generation dendrimers based on a simple calix[4]arene scaffold by insertion of the iminosugar-analogue C2-symmetric 3,4-dihydroxypyrrolidine is described.
Marco Marradi, Stefano Cicchi, Francesco Sansone, Alessandro Casnati, Andrea Goti   +4 more
doaj   +1 more source

D(-)lentiginosine-induced apoptosis involves the intrinsic pathway and is p53-independent [PDF]

, 2012
We have recently found that D(-)lentiginosine, a synthetic iminosugar exerting glucosidase inhibitory activity, but not its natural enantiomer lentiginosine, is endowed with an unexpected, pro-apoptotic activity. Here, we investigated mechanisms involved
Brandi, A, Cordero, FM, Grelli, S, Macchi, B, Marino-Merlo, F, Mastino, A, Minutolo, A   +6 more
core   +1 more source

Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes.

PLoS Neglected Tropical Diseases, 2016
It has long been thought that iminosugar antiviral activity is a function of inhibition of endoplasmic reticulum-resident α-glucosidases, and on this basis, many iminosugars have been investigated as therapeutic agents for treatment of infection by a ...
Andrew C Sayce, Dominic S Alonzi, Sarah S Killingbeck, Beatrice E Tyrrell, Michelle L Hill, Alessandro T Caputo, Ren Iwaki, Kyoko Kinami, Daisuke Ide, J L Kiappes, P Robert Beatty, Atsushi Kato, Eva Harris, Raymond A Dwek, Joanna L Miller, Nicole Zitzmann   +15 more
doaj   +1 more source

The Stereoselective Nitro-Mannich Reaction in the Synthesis of Active Pharmaceutical Ingredients and Other Biologically Active Compounds

Frontiers in Chemistry, 2020
The nitro-Mannich (aza-Henry) reaction, in which a nitroalkane and an imine react to form a β-nitroamine, is a versatile tool for target-oriented synthesis. Although the first stereoselective reaction was developed only 20 years ago, and enantioselective
Ana Maria Faisca Phillips, M. Fátima C. Guedes da Silva, Armando J. L. Pombeiro   +2 more
doaj   +1 more source

The crystal structures of 3-O-benzyl-1,2-O-isopropylidene-5-O-methanesulfonyl-6-O-triphenylmethyl-α-d-glucofuranose and its azide displacement product

Acta Crystallographica Section E: Crystallographic Communications, 2018
The effect of different leaving groups on the substitution versus elimination outcomes with C-5 d-glucose derivatives was investigated. The stereochemical configurations of 3-O-benzyl-1,2-O-isopropylidene-5-O-methanesulfonyl-6-O-triphenylmethyl-α-d ...
Zane Clarke, Evan Barnes, Kate L. Prichard, Laura J. Mares, Jack K. Clegg, Adam McCluskey, Todd A. Houston, Michela I. Simone   +7 more
doaj   +1 more source

Synthesis of Piperidine Nucleosides as Conformationally Restricted Immucillin Mimics

Molecules, 2021
The de novo synthesis of piperidine nucleosides from our homologating agent 5,6-dihydro-1,4-dithiin is herein reported. The structure and conformation of nucleosides were conceived to faithfully resemble the well-known nucleoside drugs Immucillins H and ...
Maria De Fenza, Anna Esposito, Daniele D’Alonzo, Annalisa Guaragna   +3 more
doaj   +1 more source

N-Alkylated Iminosugar Based Ligands: Synthesis and Inhibition of Human Lysosomal β-Glucocerebrosidase

Molecules, 2020
The scope of a series of N-alkylated iminosugar based inhibitors in the d-gluco as well as d-xylo configuration towards their interaction with human lysosomal β-glucocerebrosidase has been evaluated.
Andreas Wolfsgruber, Martin Thonhofer, Patrick Weber, Seyed A. Nasseri, Roland Fischer, Michael Schalli, Arnold E. Stütz, Stephen G. Withers, Tanja M. Wrodnigg   +8 more
doaj   +1 more source

Miglustat Reverts the Impairment of Synaptic Plasticity in a Mouse Model of NPC Disease [PDF]

, 2016
Niemann-Pick type C disease is an autosomal recessive storage disorder, characterized by abnormal sequestration of unesterified cholesterol within the late endolysosomal compartment of cells and accumulation of gangliosides and other sphingolipids ...
Cardinale, A, Cutarelli, A, D'Arcangelo, G, Frank, C, Grossi, D, Merlo, D, Racaniello, M, Rufini, S, Tancredi, V, Zaratti, A   +9 more
core   +8 more sources

N-Azidoacetylmannosamine-mediated chemical tagging of gangliosides

Journal of Lipid Research, 2007
Peracetylated N-α-azidoacetylmannosamine (Ac4ManNAz) is metabolized by cells to CMP-azidosialic acid. It has been demonstrated previously that in this way azidosialic acid-containing glycoproteins are formed that can be labeled on the cell surface by a ...
Anton P. Bussink, Paul F. van Swieten, Karen Ghauharali, Saskia Scheij, Marco van Eijk, Tom Wennekes, Gijs A. van der Marel, Rolf G. Boot, Johannes M.F.G. Aerts, Herman S. Overkleeft   +9 more
doaj   +1 more source

Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease. [PDF]

PLoS ONE, 2011
The neuropathic glycosphingolipidoses are a subgroup of lysosomal storage disorders for which there are no effective therapies. A potential approach is substrate reduction therapy using inhibitors of glucosylceramide synthase (GCS) to decrease the ...
Karen M Ashe, Dinesh Bangari, Lingyun Li, Mario A Cabrera-Salazar, Scott D Bercury, Jennifer B Nietupski, Christopher G F Cooper, Johannes M F G Aerts, Edward R Lee, Diane P Copeland, Seng H Cheng, Ronald K Scheule, John Marshall   +12 more
doaj   +1 more source